Protective effect of Citri Unshius Pericarpium against cadmium-induced liver damage in mice
![]() |
Noh, Gyu Pyo
(College of Korean Medicine, Daegu Haany University)
Lee, Jong Rok (Department of Pharmaceutical Engineering, Daegu Haany University) Kim, Jae Kwang (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) Park, Sang Mi (College of Korean Medicine, Daegu Haany University) Park, Sook Jahr (Department of Pharmaceutical Engineering, Daegu Haany University) Kim, Sang Chan (College of Korean Medicine, Daegu Haany University) |
1 | Luo T, Yuan Y, Yu Q, Liu G, Long M, Zhang K, Bian J, Gu J, Zou H, Wang Y, Zhu J, Liu X, Liu Z. PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway. Sci Rep. 2017;7:4331. DOI |
2 | Aja PM, Izekwe FI, Famurewa AC, Ekpono EU, Nwite FE, Igwenyi IO, Awoke JN, Ani OG, Aloke C, Obasi NA, Udeh KU, Ale BA. Hesperidin protects against cadmium-induced pancreatitis by modulating insulin secretion, redox imbalance and iNOS/NF-κB signaling in rats. Life Sci . 2020;259:118268. DOI |
3 | Khan MHA, Parvez S. Hesperidin ameliorates heavy metal induced toxicity mediated by oxidative stress in brain of Wistar rats. J Trace Elem Med Biol. 2015;31:53-60. DOI |
4 | Leelavinothan P, Kalist S. Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats. Exp Toxicol Pathol. 2012;64(5): 513-20. DOI |
5 | Lasfer M, Vadrot N, Aoudjehane L, Conti F, Bringuier AF, Feldmann G, Reyl-Desmars F. Cadmium induces mitochondria-dependent apoptosis of normal human hepatocytes. Cell Biol Toxicol. 2008;24(1):55-62. DOI |
6 | Toppo R, Roy BK, Gora RH, Baxla SL, Kumar P. Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats. Vet World. 2015;8:537-40. DOI |
7 | Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87:315-424. DOI |
8 | Jin SY, Kang SS, Lee DW, Yim SJ, Yun YH, Lee BI. Expression of matrix metalloproteinase (MMP)-1, MMP-3 nitrotyrosine and apoptosis in articular cartilage of human osteoarthritis. Korean J Pathol. 2001;35(4):319-29. |
9 | Bong JG, Park YY. Antioxidant effect of hederagenin 3-O-b-D-glucopyranosyl ( 1 → 3 )-a-L-rhamnopyranosyl (1→2)-a-L-arabinopyranoside(HDL) isolated from root bark of ulmus davidiana. J Life Sci. 2010;20(2):281-91. DOI |
10 | Ham MJ, Kim YS. Effects of Polygalae Radix Preparata Cum Glycyrrhizae Radix on 4-HNE-induced apoptosis in PC-12 cell. Kor J Herbology. 2016;31(1):77-82. DOI |
11 | Tsai YF, Chen YR, Chen JP, Tang Y, Yang KC. Effect of hesperidin on anti-inflammation and cellular antioxidant capacity in hydrogen peroxide-stimulated human articular chondrocytes. Process Biochem. 2019;85:175-84. DOI |
12 | Satarug S, Moore MR. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect. 2004;112(10):1099-103. DOI |
13 | Jarup L, Åkesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol. 2009;238:201-8. DOI |
14 | Menke A, Munter P, Silbergeld EK, Platz EA, Guallar E. Cadmium levels in urine and mortality among U.S. adults. Environ Health Perspect. 2009;117(2):190-6. DOI |
15 | Oriental Pharmacology Committee. Oriental Pharmacology. Seoul : Shinil. 2006 : 613-6. |
16 | Jung JK, Son KH, Kim YS, Park YK. Effect of Citri Pericarpium ethanol extract on collagen-induced arthritis in mice. Kor J Herbology. 2011;26(3):1-6. DOI |
17 | Shi Q, Liu Z, Yang Y, Geng P, Zhu YY, Zhang Q, Bai F, Bai G. Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects. Acta Pharmacol Sin. 2009;30: 567-75. DOI |
18 | Yang G, Lee J, Jung ED, Ham I, Choi HY. Lipid lowering activity of Citri unshii pericarpium in hyperlipemic rats. Immunopharmacol Immunotoxicol. 2008;30:783-91. DOI |
19 | Shin YW. Changes in the anti allergic effect of Citrus unshii Pericarpium according to storage period. Kor J Herbology. 2012;27(5):37-44. DOI |
20 | Oh YL. Effect of antioxidant of Citri Reticulatae Pericarpium on cytotoxicity of oxygen free radicals in cultured NIH3T3 fibroblast. Kor J Herbology. 2006;21(4):143-8. |
21 | Haouem S, Hmad N, Najjar MF, Hani AE, Sakly R. Accumulation of cadmium and its effects on liver and kidney functions in rats given diet containing cadmium-polluted radish bulb. Exp Toxicol Pathol. 2007;59:77-80. DOI |
22 | Park SJ, Lee JR, Jo MJ, Park SM, Ku SK, Kim SC. Protective effects of Korean red ginseng extract on cadmium-induced hepatic toxicity in rats. J Ginseng Res. 2013;37:37-44. DOI |
23 | Ramamurthy CH, Subastri A, Suyavaran A, Subbaiah KC, Valluru L, Thirunavukkarasu C. Solanum torvum Swartz. fruit attenuates cadmium-induced liver and kidney damage through modulation of oxidative stress and glycosylation. Environ Sci Pollut Res Int. 2016;23:7919-29. DOI |
24 | Rogalska J, Pilat-Marcinkiewicz B, Brzoska MM. Protective effect of zinc against cadmium hepatotoxicity depends on this bioelement intake and level of cadmium exposure: a study in a rat model. Chem Biol Interact. 2011;193:191-203. DOI |
25 | Li Y, Lim SC. Cadmium-induced apoptosis of hepatocytes is not associated with death receptor-related caspase-dependent pathways in the rat. Environ Toxicol Pharmacol. 2007;24:231-8. DOI |
26 | Oyinloye BE, Adenowo AF, Osunsanmi FO, Ogunyinka BI, Nwozo SO, Kappo AP. Aqueous extract of Monodora myristica ameliorates cadmium-induced hepatotoxicity in male rats. Springerplus. 2016;5:641. DOI |
![]() |