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http://dx.doi.org/10.6116/kjh.2020.35.2.1.

Chemical change of urushiol during heating process of Toxicodendron vernicifluum resin  

Kim, Jung-Hoon (Division of Pharmacology, School of Korean Medicine, Pusan National Univ.)
Doh, Eui jeong (Research Center of Traditional Korean Medicine, Wonkwang Univ.)
Lee, Guemsan (Research Center of Traditional Korean Medicine, Wonkwang Univ.)
Publication Information
The Korea Journal of Herbology / v.35, no.2, 2020 , pp. 1-6 More about this Journal
Abstract
Objectives : Heating process is the traditional processing method that has been applied to reduce the toxicity of dried resin of Toxicodendron vernicifluum (Anacardiacea) used as Geon-chil (乾漆, Lacca Rhois Exsiccata or Toxicodendri Resina). Urushiol, which is found in the plants of Toxicodendron genus, is a toxic compound that is absorbed into the skin and induces allergic dermatitis by being contacted. Hence, the reduction of urushiol level by heating processing of Geon-chil is crucial method for its medicinal application. Methods : Due to lack of Geon-chil processing-related articles, the articles researching the processing of lacquer (漆), as a coating material, were collected and analyzed to investigate the chemical change of urushiol during heating process. Results : The results demonstrate that the resin which was collected from the sap of T. vernicifluum tree was dried under warm and humid conditions repeatedly. During primary drying process, the laccase, a copper-containing enzyme in the resin, participated in the formation of urushiol polymers and thereafter urushiol-related toxicity could be reduced by making a lacquer harder and more stable. Moreover, heating a lacquer over 200℃ could cause thermo-degradation of urushiol polymers, and vaporized thermally degraded urushiol monomers and their by-products, which were determined using pyrolysis/GC-MS. Conclusions : These results support that heating process being performed over 200 ℃, such as stir-frying (炒) or calcination (煅), reduces the urushiol content in Geon-chil and hence, its medicinal use can be more stable without urushiol-related allergic reactions.
Keywords
Toxicodendron vernicifluum; Geon-chil (乾 漆 ); Urushiol; Toxicodendri Resina; Lacca Rhois Exsiccata; Heating process;
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Times Cited By KSCI : 4  (Citation Analysis)
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