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http://dx.doi.org/10.6116/kjh.2019.34.6.63.

Morphological Characteristics, Distribution and Taxonomic Consideration of the Arnebia euchroma and A. guttata  

Song, Jun-Ho (Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine)
Choi, Goya (Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine)
Yang, Sungyu (Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine)
Moon, Byeong Cheol (Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine)
Publication Information
The Korea Journal of Herbology / v.34, no.6, 2019 , pp. 63-70 More about this Journal
Abstract
Objective : Arnebiae Radix, the roots of Arnebia euchroma (Royle) Johnst. or A. guttata Bunge, is a well-known traditional herbal medicine in East Asia. In the Korean Pharmacopoeia, three authentic species, including two Arnebia and Lithospermum erythrorhizon Sieb. et Zucc. have recognized as a Lithospermi Radix. But, the morphological and taxonomic information of two authentic Arnebia species lacks date since their distribution and difficulty of accessing the natural habitats. Methods : A full description of the external morphological characteristics of vegetative and reproductive organs in the original plants was carried out using digital calipers and stereoscope. For providing their taxonomic and nomenclatural synonyms, we reviewed various plant checklists and taxonomic literature. Results : This study provides taxonomic information of A. euchroma and A. guttata based on a morphological examination of authentic plant individuals and field observations. Detailed descriptions of the two Arnebia species, major quantitative and qualitative characteristics, nomenclatural reviews, distribution maps, and lists of voucher specimens examined are provided. The shape of leaves, root length, stem number, calyx length and pubescence as well as corolla color were useful characteristics for identification. Moreover, we confirmed that A. euchroma and A. guttata are clearly heterostylous species. Conclusion : Our research provides valuable basic information that could be used as quality control for distinguishing between Arnebiae Radix and its adulterants. These results will help in the understanding of authentic plants and also provide the verified materials and voucher information.
Keywords
Arnebiae Radix; Lithospermi Radix; Arnebia euchroma (Royle) Johnst.; Arnebia guttata Bunge; Arnebia tibetana Kurz.; Stereoscope; Descriptions;
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1 Damianakos H, Kretschmer N, Syklowska-Baranek K, Pietrosiuk A, Bauer R, Chinou I. Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst. (Boraginaceae) callus and cell suspension culture. Molecules 2012 ; 17(12) : 14310-22.   DOI
2 Haghbeen K, Pourmolaei S, Marefatjo MJ, Mosavi A, Meshkat A. Detailed investigations on the solid cell culture and anti-microbial activities of the Iranian Arnebia euchroma . J. Biomed. Biotechnol. 2011 ; 2011 : 165852.
3 He JM, Sun SC, Sun ZL, Chen JT, Mu Q. Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antimicrobial resistance of drug-resistant Staphylococcus aureus . Int. J. Antimicrob. Agents 2019 ; 53(1) : 70-3.   DOI
4 Ashkani Esfahani S, Imanieh MH, Ebrahim S, Noorafshan A. The healing effect of Arnebia euchroma in second degree burn wounds in rat and animal model. Iran Red. Crescent. Med. J. 2012 ; 14(2) : 70-4.
5 Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S, Azadbakht M. The healing effect of Arnebia euchroma ointment versus silver sulfadiazine on burn wounds in rat. World J. Plast. Surg. 2015 ; 4(2) : 134-44.
6 Nasiri E, Hosseinimehr SJ, Hosseinzadeh AZ, Azadbakht M, Akbari J, Azadbakht M. The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial. J. Ethnopharmacol. 2016 ; 189 : 107-16.   DOI
7 Abdulameer A, Mussawi AI. Isolation and identification of shikonin from Arnebia decumbens L. and its antibacterial activity. J. Appl. Sci. Res. 2010 ; 6(9) : 1452-6.
8 Kim GS, Park CG, Lee KH, Choi J, Lee SE, Noh HJ, Lee JH, Kim S.Y. Investigation of shikonin pigments and antioxidant activity of the roots from Lithospermum erythrorhizon according to the different growth stages and areas of cultivation. Korean J. Medicinal Crop Sci. 2011 ; 19(6) : 435-40.   DOI
9 Sabokbar A, Tabaraie B, Karimi MZ, Talebi S. Study of the antifungal activity of shikonin and alcoholic-oily extracts of Iranian Arnebia euchroma L. Int. J. Sci. Basic Appl. 2017 ; 2(2) : 106-10.   DOI
10 Kim YD. Boraginaceae Juss. In: Park CW (ed.), The Genera of Vascular Plants of Korea. Academy Publishing Co. 2007 : 804-5.
11 Ahn YH, Jin YH, Choe CY, Lee KM, Lee SH. Ecological characteristics of Lithospermum erythrorhizon population in habitats. Korean J. Pharmacogn. 2010 ; 40(4) : 289-97.
12 Ahn YM, Lee ST. A palynotaxonomic study of the Korean Boraginaceae. Korean J. Pl. Taxon. 1986 ; 16(3) : 199-215.   DOI
13 Fang RC, Staples GW. Arnebia Forsskal In: Wu ZY and Raven PH (eds.), Flora of China. Vol. 16. Beijing & St. Louis : Science Press and Missouri Botanical Garden Press. 1995 : 344-6.
14 Royle JF. Lithospermum euchromon Royle Ill. Bot. Himal. Mts. 1839 ; 1 : 305.
15 Bunge AA. Arnebia guttata Bunge, Index Seminum (St. Petersburg) 1840 ; 1840 : 7.
16 Johnston IM. Arnebia euchroma (Royle) Johnst. Contr. Gray Herb. 1924 ; 73 : 49.
17 Tojibaev KSh, Beshko NYu, Kadyrov RU, Gaziev AD, Oh BU, Jang CG, Shin CH, Chio K. Flora of the Western Tien Shan. The Chimgan Mountains. Korea National Arboretum 2015 : 228.
18 Kokoreva II, Sytpaeva GT, Kudavaeva GM, Otradnych IG, Sednya IA. Flora of the Northern Tien Shan. The Chu-Ili Mountains. Korea National Arboretum. 2018 : 207.
19 Park CW. 2019. The Genera of Vascular Plants of Korea. In: Park CW (ed.), Academy Publishing Co.
20 Kim HK, Moon BC, Kang YM, Choi GY, Ji YU, Ju YS, Seo YB, Choo B.K. Korean Medicinal Materials. Vol. 1. Korea Institute of Oriental Medicine. Daejeon. 2014.
21 Ju YS, Choo BK, Seo YB, Choi GY, Moon BC, Yang SG, Lee JH, Kang YM. Korean Medicinal Materials. Vol. 2. Korea Institute of Oriental Medicine. Daejeon. 2015.
22 Ju YS, Choo BK, Seo YB, Choi GY, Moon BC, Yang SG. Korean Medicinal Materials. Vol. 3. Korea Institute of Oriental Medicine. Daejeon. 2017.
23 Wang LL, Zhang C, Tian B, Sun XD, Guo W, Zhang TF, Yang YP, Duan YW. Reproductive isolation is mediated by pollen incompatibility in sympatric populations of two Arnebia species. Ecol. Evol. 2015 ; 5(24) : 5838-46.   DOI
24 Zhang C, Wang LL, Lan D, Yang YP, Duan YW. Pollination ecology of Arnebia szechenyi (Boraginaceae), a Chinese endemic perennial characterized by distyly and heteromorphic selfncompatibility. Ann. Bot. Fenn. 2014 ; 51(5) : 297-305.   DOI
25 Coppi A, Cecchi L, Nocentini D, Selvi F. Arnebia purpurea : a new member of formerly monotypic genus Huynhia (Boraginaceae-Lithospermeae). Phytotaxa 2015 ; 204(2) : 123-36.   DOI
26 Lazkov GA, Sultanova BA. Checklist of Vascular Plants of Kyrgyzstan. - United Nations Development Programme, Bishkek. 2014.
27 Committee on Chinese Medicine and Pharmacy. Taiwan Herbal Pharmacopeia 2nd ed. English Version. Taipei City : Ministry of Health and Welfare. 2013 : 204.
28 Korea Food and Drug Administration. Korean Pharmacopoeia 11th ed. The KFDA Notification No. 2017-63. 2016 Jul 31th.
29 Pharmacopoeia Committee of the DPRK. Pharmacopoeia of Democratic People's Republic of Korea 7th ed. Pyeongyang : Medicine and Science Press. 2011.
30 Chinese Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China 2015 ed. Part I. Beijing : China Medical Science and Technology Press. 2015.
31 Ministry of Health, Labour and Welfare. Japanese Pharmacopoeia 17th ed. The MHLW Ministerial Notification No. 64. 2016 Apr 1st.
32 Kim SH, Kang IC, Yoon TJ, Park YM, Kang KS, Song GY, Ahn BZ. Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33. Cancer Lett. 2001 ; 172(2) : 171-5.   DOI
33 Han J, Weng X, Bi K. Antioxidants from a Chinese medicinal herb-Lithospermum erythrorhizon. Food Chemistry 2008 ; 106 : 2-10.   DOI
34 Staniforth V, Wang SY, Shyur LF, Yang NS. Shikonins, phytocompounds from Lithospermum erythrorhizon , inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. J. Biol. Chem. 2004 ; 279(7) : 5877-85.   DOI
35 Chung HS, Kang MK, Cho CW, Park SK, Kim HY, Yoon YS, Kang JH, Shin MK, Hong MC, Bae HS. Inhibition of lipopolysaccharide and interferongammainduced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages. J. Ethnopharmacol. 2005 ; 102(3) : 412-7.   DOI
36 Zhang ZQ, Cao XC, Zhang L, Zhu WL. Effect of shikonin, a phytocompound from Lithospermum erythrorhizon , on rat vascular smooth muscle cells proliferation and apoptosis in vitro. Zhonghua Yi Xue Za Zhi 2005 ; 85(21) : 1484-8.
37 Lee HJ, Lee HJ, Magesh V, Nam DW, Lee EO, Ahn KS, Jung MH, Ahn KS, Kim DK, Kim JY, Kim SH. Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in Lewis lung carcinoma-bearing mice. Yakugaku Zasshi 2008 ; 128 : 1681-8.   DOI
38 Choi WH, Hong SS, Lee SA, Han XH, Lee KS, Lee MK, Hwang BY, Ro JS. Monoamine oxidase inhibitory naphthoquinones from the roots of Lithospermum erythrorhizon . Arch. Pharm. Res. 2005 ; 28(4) : 400-4.   DOI
39 Tanaka S, Tajima M, Tsukada M, Tabata M. A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin. J. Nat. Prod. 1986 ; 49 : 466-9.   DOI
40 Tiana L, Wang Z, Wu H, Wang S, Wang Y, Wang Y, Xu J, Wang L, Qi F, Fang M, Yu D, Fang X. Evaluation of the anti-neuraminidase activity of the traditional Chinese medicines and determination of the anti-influenza a virus effects of the neuraminidase inhibitory TCMs in vitro and in vivo. J. Ethnopharmacol. 2011 ; 137 : 534-42.   DOI
41 Bulgakov VP, Veselova MV, Tchernoded GK, Kiselev KV, Fedoreyev SA, Zhuravlev YN. Inhibitory effect of the Agrobacterium rhizogenes rolC gene on rabdosiin and rosmarinic acid production in Eritrichium sericeum and Lithospermum erythrorhizon transformed cell cultures. Planta 2005 ; 221(4) : 471-8.   DOI
42 Bo S, Dan M, Li, W, Zhang P. Characterizations and immunostimulatory activities of a polysaccharide from Arnebia euchroma (Royle) Johnst. roots. Int. J. Biol. Macromol. 2019 ; 125 : 791-9.   DOI
43 Doulah AH, Neisi N, Zekavati R, Farjam MH. Antibacterial antifungal and antioxidant activity of four species from Arnebia genus growing wild in Iran. Iran J. Sci. Technol. 2014 ; 28(2) : 159-64.
44 Sharma N, Gulati A, Kumar D, Padwad Y. Naphthazarins as cytotoxic agents isolated from Arnebia euchroma. Pharmacogn. Mag. 2019 ; 15(64) : 366-70.   DOI
45 Zhu Y, Zhong Y, Long X, Zhu Z, Zhou Y, Ye H, Zeng X, Zheng X. Deoxyshikonin isolated from Arnebia euchroma inhibits colorectal cancer by down-regulating the PI3K/Akt/mTOR pathway. Pharm. Biol. 2019 ; 57(1) : 412-23.   DOI