Anti-inflammatory Effects of Ethanol Extract of Korean Medicinal Plants at Hwaak Mountain in LPS-induced RAW 264.7 Macrophages |
Kang, Yun-Mi
(Department of Pharmacology, College of Korean Medicine, Sangji University)
Jeon, Eun-jin (Department of Pharmacology, College of Korean Medicine, Sangji University) Chung, Kyung-Sook (Catholic Precision Medicine Research Center, College of Medicine, The Catholic University of Korea) Cheon, Se-Yun (Department of Pharmacology, College of Korean Medicine, Sangji University) Park, Jong Hyuk (Institute of Natural Cosmetic Industry for Namwon) Han, Yoo-Chang (Dodan Korean Medicine Clinic) An, Hyo-Jin (Department of Pharmacology, College of Korean Medicine, Sangji University) |
1 | Guzik, T.J., R. Korbut, and T. Adamek-Guzik, Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol. 2003;54(4): 469-87. |
2 | Feng, G.J., H.S. Goodridge, M.M. Harnett, X.Q. Wei, A.V. Nikolaev, A.P. Higson, and F.Y. Liew, Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol. 1999;163(12): 6403-12. |
3 | Hu, B., H. Zhang, X. Meng, F. Wang, and P. Wang, Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. J Ethnopharmacol. 2014;153(3): 846-53. DOI |
4 | Li, Q. and I.M. Verma, NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2(10): 725-34. DOI |
5 | Hayden, M.S. and S. Ghosh, Regulation of NF-kappaB by TNF family cytokines. Semin Immunol. 2014;26(3): 253-66. DOI |
6 | Park, H. and H.S. Kim, Korean traditional natural herbs and plants as immune enhancing, antidiabetic, chemopreventive, and antioxidative agents: a narrative review and perspective. J Med Food. 2014;17(1): 21-7. DOI |
7 | Lee, J.S., A. Synytsya, H.B. Kim, D.J. Choi, S. Lee, J. Lee, W.J. Kim, S. Jang, and Y.I. Park, Purification, characterization and immunomodulating activity of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.). Int Immunopharmacol. 2013;17(3): 858-66. DOI |
8 | Han, J.M., M.H. Kim, Y.Y. Choi, H. Lee, J. Hong, and W.M. Yang, Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-gamma Activation in Rats. Phytother Res. 2015;29(10): 1616-21. DOI |
9 | Kim, B.W., S. Koppula, S.Y. Park, J.W. Hwang, P.J. Park, J.H. Lim, and D.K. Choi, Attenuation of inflammatory-mediated neurotoxicity by Saururus chinensis extract in LPS-induced BV-2 microglia cells via regulation of NF-kappaB signaling and anti-oxidant properties. BMC Complement Altern Med. 2014;14: 502. DOI |
10 | Lee, S.I., S.H. Oh, K.Y. Park, B.H. Park, J.S. Kim, and S.D. Kim, Antihyperglycemic effects of fruits of privet (Ligustrum obtusifolium) in streptozotocin-induced diabetic rats fed a high fat diet. J Med Food. 2009;12(1): 109-17. DOI |
11 | Cheon, S.Y., K.S. Chung, E. Jeon, A. Nugroho, H.J. Park, and H.J. An, Anti-inflammatory Activity of Saxifragin via Inhibition of NF-kappaB Involves Caspase-1 Activation. J Nat Prod. 2015;78(7): 1579-85. DOI |
12 | Kim, I.T., S. Ryu, J.S. Shin, J.H. Choi, H.J. Park, and K.T. Lee, Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-kappaB inactivation in RAW 264.7 macrophages. J Cell Biochem. 2012;113(6): 1936-46. DOI |
13 | Giri, S.S., S.S. Sen, V. Sukumaran, and S.C. Park, Pinocembrin attenuates lipopolysaccharideinduced inflammatory responses in Labeo rohita macrophages via the suppression of the NF-kappaB signalling pathway. Fish Shellfish Immunol. 2016;56: 459-66. DOI |
14 | West, M.A., S.C. Seatter, J. Bellingham, and L. Clair, Mechanisms of reprogrammed macrophage endotoxin signal transduction after lipopolysaccharide pretreatment. Surgery. 1995;118(2): 220-8. DOI |
15 | Bae, G.S., M.S. Kim, W.S. Jung, S.W. Seo, S.W. Yun, S.G. Kim, R.K. Park, E.C. Kim, H.J. Song, and S.J. Park, Inhibition of lipopolysaccharide-induced inflammatory responses by piperine. Eur J Pharmacol. 2010;642(1-3): 154-62. DOI |
16 | Kim, K.N., S.J. Heo, W.J. Yoon, S.M. Kang, G. Ahn, T.H. Yi, and Y.J. Jeon, Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-kappaB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages. Eur J Pharmacol. 2010;649(1-3): 369-75. DOI |
17 | Foster, J.R., The functions of cytokines and their uses in toxicology. Int J Exp Pathol. 2001;82(3): 171-92. DOI |
18 | Saukkonen, K., S. Sande, C. Cioffe, S. Wolpe, B. Sherry, A. Cerami, and E. Tuomanen, The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J Exp Med. 1990;171(2): 439-48. DOI |
19 | Cho, E.J., H.J. An, J.S. Shin, H.E. Choi, J. Ko, Y.W. Cho, H.M. Kim, J.H. Choi, and K.T. Lee, Roxatidine suppresses inflammatory responses via inhibition of NF-kappaB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. J Cell Biochem. 2011;112(12): 3648-59. DOI |
20 | Lee, H.J., J.S. Shin, W.S. Lee, H.Y. Shim, J.M. Park, D.S. Jang, and K.T. Lee, Chikusetsusaponin IVa Methyl Ester Isolated from the Roots of Achyranthes japonica Suppresses LPS-Induced iNOS, TNF-alpha, IL-6, and IL-1beta Expression by NF-kappaB and AP-1 Inactivation. Biol Pharm Bull. 2016;39(5): 657-64. DOI |
21 | Verstrepen, L., T. Bekaert, T.L. Chau, J. Tavernier, A. Chariot, and R. Beyaert, TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci. 2008;65(19): 2964-78. DOI |
22 | Caglayan, K., B. Gungor, H. Cinar, B. Avci, S. Gur, and N. Arslan, Effects of oleuropein on serum inflammatory cytokines and histopathological changes in rats with pancreatitis. Adv Clin Exp Med. 2015;24(2): 213-8. DOI |
23 | Yamamoto, Y. and R.B. Gaynor, Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest. 2001;107(2): 135-42. DOI |
24 | Zandi, E., D.M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin, The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997;91(2): 243-52. DOI |
25 | Karin, M., Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc. 2005;2(4): 386-90; discussion 394-5. DOI |
26 | Konno, K., C. Hirayama, H. Yasui, and M. Nakamura, Enzymatic activation of oleuropein: a protein crosslinker used as a chemical defense in the privet tree. Proc Natl Acad Sci U S A. 1999;96(16): 9159-64. DOI |