Browse > Article
http://dx.doi.org/10.6116/kjh.2015.30.6.83.

Lipid Improvement Effect of Fermented Cynanchi wilfordii Radix in Hyperlipidemia Rats  

Feng, Xiu Jin (College of Oriental Medicine, Daejeon University)
Roh, Seong-Soo (College of Oriental Medicine, Daegu Hanny university)
Oh, Dang Seop (ODS Food Corporation)
Seo, Young Bae (College of Oriental Medicine, Daejeon University)
Publication Information
The Korea Journal of Herbology / v.30, no.6, 2015 , pp. 83-91 More about this Journal
Abstract
Objectives : The present study was conducted to examine whether Cynanchi wilfordii radix (CWR) with or without fermentation has an ameliorative effect on hyperlipidemia in rats.Methods : We analyzed the contents of Conduritol F on Cynanchi wilfordii radix. The experimental animals were divided into six groups; normal diet fed group (N), high cholesterol fed control group (Con), Lovastatin 20 mg/kg (L), CWR-W 300 mg/kg (CWR-W), and CWR-F 300 mg/kg on hyperlipidemia model induced by feeding 1.25% cholesterol. Rats were administrated orally every day for 8 weeks. And lipid profile of serum and weight change were observed.Results : The vehicle displayed a markedly increased body weight and significantly increased liver and epididymal fat weight, however, the administration of CWR improved the body, liver, and epididymal fat weights. All drug treatment reduced significantly the serum level of total cholesterol and LDL-cholesterol elevated by intake of high cholesterol diet. TG displayed a reducing tendency all drug treatment, however, CWR-W decreased significantly. Atherogenic index and cardiac risk factor increased high cholesterol diet fed control group, while the administration of CWR-W and CWR-F decreased significantly. The major index of liver injury such as AST and ALT improved in all drug treatment.Conclusions : These results suggest that CWR extended the effect of lipid enhanced. Therefore CWR with or without fermentation may be useful for therapeutic treatment of clinical conditions associated with hyperlipidemia. Finally, these require more investigations about the action mechanism of CWR in the future.
Keywords
Cynanchi wilfordii radix; High cholesterol diet; Hyperlipidemia; Fermentation;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Ding M, Si D, Zhang W, Feng Z, He M, Yang P. Red yeast rice repairs kidney damage and reduces inflammatory transcription factors in rat models of hyperlipidemia. Exp Ther Med. 2014 ; 8(6) : 1737-44.   DOI
2 Kang DG, Lee YM, Oh HC, Mun YJ, Lee HS, Woo WH. Effects of the Fermented Extract Using the Leaves of Pinus densiflora on Hyperlipidemia Rats. Korean J Orient Physiol Pathol. 2003 ; 17(1) : 140-5.
3 Lee YJ, Son YJ. The effects of Polygoni multiflori Radix and Cynanchi wilfordii Radix on the Blood Lipids and Enzymes of Hypercoloesterolic Rats. Kor J Herbol. 1999 ; 14(1) : 69-77.
4 Kim HS. Effects of Cynanchum wilfordii Extract on Serum Lipid Components and Enzyme Activities in Hyperlipidemic and Streptozotocin-induced Diabetic Rats. Korean J Hum Ecol. 2004 ; 7(2) : 1-11.
5 Choi DH, Lee YJ, Oh HC, Cui YL, Kim JS, Kang DG, Lee HS. Improved endothelial dysfunction by Cynanchum wilfordii in apolipoprotein E(-/-) mice fed a high fat/cholesterol diet. J Med Food. 2012 ; 15(2) : 169-79.   DOI
6 Kim MJ, Seo BI, Shin SS, Park JH. Effect of Polygoni Multiflori Radix and Cynanchi Wilfordii Radix On Prevention of Osteoporosis In Ovariectomized Rats. Kor J Herbol. 2004 ; 19(1) : 23-34.
7 Seo BI. Effects of Cynanchi Wilfordii Radix on Prevention of Hyperlipidemia and Liver Damage Induced by Alcohol. Kor J Herbol. 2008 ; 23(4) : 31-8.
8 Hwang IY, Hwang SA, Lee SH, Jeong CS. Inhibitory Effects of Cynanchum wilfordii hemsley and C. auriculatum Royle ex Wight Extracts on HCl ·ethanol-Induced Gastritis in Rats. Duksung Bull Pharm Sci. 2011 ; 22 : 25-32.
9 Liu SJ, Ramsey RK, Fallon HJ. Effects of ethanol on hepatic microsomal drug-metabolizing enzymes in the rat. Biochem Pharmacol. 1975 ; 24(3) : 369-78.   DOI
10 Ham IH, Lee JY, Yoon YJ, Yang GS, Tae J, Bu YM, Kim HC, Choi HY. Effects of Cynanchum spp. on the hyperlipidemia in rats induced by Triton WR-1339. Kor J Herbol. 2007 ; 22(4) : 279-86.
11 Shin YO, Park CH, Lee GH, Yokozawa T, Roh SS, Rhee MH. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evid Based Complement Alternat Med. 2015 ; 2015 : 456846.
12 Choi HT, Kim ES, Ham SS, Park SY, Chung HY. Effects of Complex Food Ingredient Composed of Garlic and Fermented Soybean Hypocotyl on the Serum Lipid Profiles of the Rats Fed High-Fat Diet. Korean J Food Sci Technol. 2008 ; 40(2) : 215-9.
13 Jung MA, Cho SH, Lee SY, Kim JH, Oh KN, Kim YS, Yoo GS, Lee DW, Kim SO. Effects of Unripe Rubus coreanus Miquel Extract on Improvement of Lipid Metabolism in C57BL/6 Mice Fed a High-Cholesterol Diet. J Korean Soc Food Sci Nutr. 2014 ; 43(5) : 650-5.   DOI
14 Kamesh V, Sumathi T. Antihypercholesterolemic effect of Bacopa monniera linn. on high cholesterol diet induced hypercholesterolemia in rats. Asian Pac J Trop Med. 2012 ; 5(12) : 949-55.   DOI
15 Goryuyuihakpeynjipbu. YmsangByungrigumsahakgaeron. Seoul : Goryuyuihak. 2013 : 223-30.
16 Lee JM, Choi SW, Cho SH, Rhee SJ. Effect of Seeds Extract of Paeonia Lactiflora on antioxidative system and lipid peroxidation of liver in rats fed high-cholesterol diet. Korean J Nutr. 2003 ; 36 : 793-800.
17 Yokozawa T, Nakagawa T, Kitani K. Antioxidative activity of green tea polyphenol in cholesterol-fed rats. J Agric Food Chem. 2002 ; 50(12) : 3549-52.   DOI
18 Tomkin GH. Atherosclerosis, diabetes and lipoproteins. Expert Rev Cardiovasc Ther. 2010 ; 8(7) : 1015-29.   DOI
19 Retrieved Jun. 05, 2015, from http://www.nhis.or.kr/menu/retriveMenuSet.xx?menuId=D4000.
20 Kim TH, Son YK, Hwang KH, Kim MH. Effects of Angelica keiskei Koidzumi and Turmeric Extract Supplementation on Serum Lipid Parameters in Hypercholesterolemic Diet or P-407-Induced Hyperlipidemic Rats. J Korean Soc Food Sci Nutr. 2008 ; 37(6) : 708-713.   DOI
21 Yang YH, Yang J, Jiang QH. Hypolipidemic effect of gypenosides in experimentally induced hypercholesterolemic rats. Lipids Health Dis. 2013 ; 12 : 154.   DOI
22 Ahn HR. The study of effectiveness of herbs and the meaning of oriental medicine for Hyperlipidemia. Duksung Women's University. 2011.
23 Kim JS, Suh YK, Kim HS, Chang KJ, Choi HM. The Relationship between Serum Cholesterol Levels and Dietary Fatty Acid Patterns, Plasma Fatty Acids, and Other Lipid Profile among Korean Adults. Korean J Community Nutrition. 2003 ; 8(2) : 192-201.
24 Jang WS, Kim YS, Seol IC. Antioxidant and Lipid -lowering Effects of Artemisia capillaris on a Rat Model of Hyperlipidemia. J Korean Orient Med. 2012 ; 33(2) : 11-24.
25 Park HS, Yang KM. Effects of Cheonggukjang Powder Made with Black Foods on Liver Function and Lipid Composition in Streptozotocin-induced Diabetic Rats. Korean J Food Cookery Sci. 2013 ; 29(6) : 699-707.   DOI
26 Avram AS, Avram MM, James WD. Subcutanous fat in normal and disease status : Anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol. 2005 ; 53(4) : 671-83.   DOI
27 Lee SJ, Ha WH, Choi HJ, Cho SY, Choi JW. Effects of Saury Meat on Antihyperlipidemic and Antiarteriosclerosis Activities in Sprague-Dawley Rats. J Korean Soc Food Sci Nutr. 2011 ; 40(4) : 531-7.   DOI