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http://dx.doi.org/10.6116/kjh.2015.30.3.77.

Effects of Polygoni Multiflori Radix on prevention of hyperlipidemia and liver damage induced by alcohol  

Jang, Young Eun (Department of Korean Medicine, Daegu Haany University)
Park, Ji Ha (Department of Korean Medicine, Daegu Haany University)
Roh, Seong Soo (Department of Korean Medicine, Daegu Haany University)
Koo, Jin Suk (Dept. of Bioresource Science, Andong National University)
Seo, Bu Il (Department of Korean Medicine, Daegu Haany University)
Publication Information
The Korea Journal of Herbology / v.30, no.3, 2015 , pp. 77-82 More about this Journal
Abstract
Objectives : The Korean medical doctors use PMR(Polygoni Multiflori Radix) for nourishing the liver-kidney, loosing the bowel to relieve constipation, recovering from malaria, and clearing away heat and eliminating toxin, etc. But, this study was performed to investigate the effect of water extracts from PMR on prevention of hyperlipidemia and liver damage induced by alcohol. Methods ： Except for the normal group, we fed rat on 25% alcohol for 55 days. And the extract was administrated for the same period. We measured the serum components in rat's blood, body weight and weight of liver. Results ： At first, we observed effects of PMR on prevention of hyperlipidemia induced by alcohol. PMR group showed significant decrease of total cholesterol and triglyceride in comparison with those of the control group. PMR group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. At second, we observed effects of PMR on prevention of liver damage induced by alcohol. PMR group showed significant decrease of GOT, GPT, ALP, and LDH in comparison with those of the control group. PMR group showed significant increase of liver weight in comparison with those of the control group. Conclusions ： Reviewing these experimental results, it appears that water extracts from PMR have pharmaceutical efficacy on prevention of hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.
Keywords
Polygoni Multiflori Radix; hyperlipidemia; liver damage; alcohol;
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