Browse > Article
http://dx.doi.org/10.6116/kjh.2015.30.3.13.

Antidepressant effect of water extract of Taraxacum platycarpum through BDNF, ERK and CREB pathway  

Gu, Pil Sung (Department of Oriental Pharmaceutical Science, Kyung Hee University)
Lee, Jihye (Division of Bio-technology and Convergence, Daegu Haany University)
Choi, Yun Hee (Department of Oriental Medicine & Healthcare, WonKwang Digital University)
Jung, Ji Wook (Division of Bio-technology and Convergence, Daegu Haany University)
Publication Information
The Korea Journal of Herbology / v.30, no.3, 2015 , pp. 13-17 More about this Journal
Abstract
Objectives : Taraxacum platycarpum H. Dahlstedt has been reported to have several biological properties such as skin hydration and antiinflammation. The purpose of this study was to examine the antidepressive effects of water extract of T. platycarpum (WTP) on an animal model of depression. Methods : In the present study, normal ICR mice (4 weeks) were used, and orally administered with WTP (25, 50 and 100 mg/kg). Depression-like behavior was monitored the forced swimming test (FST) and tail suspension test (TST) in mice. The locomotor activity was evaluated to eliminate the false-positive activity in the open field test (OFT). Fluoxetine, the selective serotonin reuptake inhibitor, as a positive control was intraperitoneally administered at a dose of 15 mg/kg at 30 min before starting the behavioral test. Moreover, we evaluated the effects of WTP on the expression of brain-derived neurotrophic factor (BDNF) and the extracellular signal-regulated kinase (ERK)/ cyclic AMP response-element binding protein (CREB) signaling pathway in the hippocampus using Western blot. Results : The administration of WTP (50 and 100 mg/kg) significantly (P < 0.05, respectively) reduced the immobility time during FST and TST without accompanying changes in locomotor activity by OFT. Furthermore, WTP at dose of 100 mg/kg increased the BDNF expression and the phosphorylation of ERK and CREB in the hippocampus region. Conclusions : These results suggest that WTP has a useful anti-depressant effect through the regulation of BDNF/ERK/CREB signaling pathway.
Keywords
Taraxacum platycarpum; Antidepression; Forced swimming test; Tail suspension test; Open field test;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Bijlsma EY, Chan JS, Olivier B, Veening JG, Millan MJ, Waldinger MD, Oosting RS. Sexual side effects of serotonergic antidepressants: mediated by inhibition of serotonin on central dopamine release?. Pharmacol Biochem Behav. 2014 ; 121 : 88-101.   DOI   ScienceOn
2 Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet. 1997 ; 349(9064) : 1498-504.   DOI   ScienceOn
3 Shim RS, Baltrus P, Ye J, Rust G. Prevalence, treatment, and control of depressive symptoms in the United States: results from the National Health and Nutrition Examination Survey (NHANES), 2005-2008. J Am Board Fam Med. 2011 ; 24(1) : 33-8.   DOI   ScienceOn
4 Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006 ; 3(11) : e442.   DOI
5 Gareri P, Falconi U, De Fazio P, De Sarro G. Conventional and new antidepressant drugs in the elderly. Prog Neurobiol. 2000 ; 61(4) : 353-96.   DOI   ScienceOn
6 Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med. 2008 ; 358(3) : 252-60.   DOI   ScienceOn
7 Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci. 2002 ; 23(5) : 238-45.   DOI   ScienceOn
8 Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease. Prog Neurobiol. 2001 ; 63(1) : 71-124.   DOI   ScienceOn
9 Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain - derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002 ; 109(2) : 143-8.   DOI   ScienceOn
10 Bae KH, The medicinal plants of Korea. Seoul : Kyu-hak Pub. Co. 2000 : 515-6.
11 Duman RS, Vaidya VA. Molecular and cellular actions of chronic electroconvulsive seizures. J ECT. 1998 ; 14(3) : 181-93.   DOI
12 Liebenberg N, Müller HK, Fischer CW, Harvey BH, Brink CB. An inhibitor of cAMP-dependent protein kinase induces behavioral and neurological antidepressant - like effects in rats. Neurosci Lett. 2011 ; 498(2) : 158–61.   DOI   ScienceOn
13 Qi X, Lin W, Li J, Li H, Wang W. Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depression-like behavior in rats exposed to chronic forced swim stress. Neurobiol Dis. 2008 ; 31(2) : 278–85.   DOI   ScienceOn
14 Kim HW, Kim BJ, Lim SH, Kim HY, Lee SY, Cho SI, Kim YK. Anti-oxidative effects of taraxaci herba and protective effects on human HaCaT keratinocyte. Kor J Herbol. 2009 ; 24(3) : 103-8.
15 You JY, Woo C, Jeong HR, Choi JH, Lee UJ. Experimental Study on the Antidepressant Effects of Magnolia Officinalis Extracts. Korean J Orient Int Med. 2013 ; 34(3) : 256-66.
16 Yun SI, Cho HR, Choi HS. Anticoagulant from Taraxacum platycarpum. Biosci Biotechnol Biochem. 2002 ; 66(9) : 1859-64.   DOI   ScienceOn
17 Lee DS, Li B, Lee YJ, Chum HJ, Ryu IH, Lee YJ, Chae GU, Kwon YS, Shon JU, Kang HG, Lee SH, An RB, Lee HS. Anti-inflammatory effect of extracts from the roots of Taraxacum coreanum on lipopolysacchaide - induced inflammation in BV2 cells. Kor J Oral Maxillofac Pathol. 2011 ; 35(4) : 231-8.
18 Kang HW, Jang HH, Kang IS, Moon HC, Hwang YJ, Lyu YS. A study on the oriental-medical understanding of depression. J Oriental Neuropsychiatry. 2001 ; 12(2) : 1-15.
19 Yankelevitch-Yahav R, Franko M, Huly A, Doron R. The Forced Swim Test as a Model of Depressive - like Behavior. J Vis Exp. 2015 ; 2(97) : doi: 10.3791 / 52587.   DOI
20 Lee DK, Gwak DG, Park SD. Antidepressant effect of Licium chinense Mill. and its influence on indoleamine and its metabolite of depression model rats. Herbal formula science. 2003 ; 11(2) : 185-96.
21 Ko SY, Kim DH, Lee TH. Effect of Glycyrrhizae Radix Water Extract on the depression induced by LPS in Rats. Kor J Herbol. 2014 ; 29(5) : 9-16.   DOI   ScienceOn
22 Su J, Hato-Yamada N, Araki H, Yoshimura H. Test-retest paradigm of the forced swimming test in female mice is not valid for predicting antidepressant - like activity: participation of acetylcholine and sigma-1 receptors. J Pharmacol Sci. 2013 ; 123(3) : 246-55.   DOI
23 Takano K, Yamasaki H, Kawabe K, Moriyama M, Nakamura Y. Imipramine induces brain-derived neurotrophic factor mRNA expression in cultured astrocytes. J Pharmacol Sci. 2012 ; 120(3) : 176-86.   DOI
24 Cho MJ. The 2011 epidemiological survey of mental disorders among Korean adults. Seoul : Seoul National University College of Medicine. 2011.
25 Gould TD, Manji HK. Signaling networks in the pathophysiology and treatment of mood disorders. J Psychosom Res. 2002 ; 53(2) : 687-97.   DOI   ScienceOn