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http://dx.doi.org/10.6116/kjh.2015.30.2.37.

The Effects of Licorice Supplementation on Muscle Injury, Cortisol, Testosterone and Insulin Sensitivity After High Intensity Resistance Exercise  

Jung, Hyun-Lyung (Exercise Metabolism Laboratory, Department of Physical Education, Kyungpook National University)
Na, Hyun-Jong (Third Oriental Medicine Hospital)
Kim, Pan-Soo (College of Martial Arts, Department of Judo, YongIn University)
Ryu, Hyung-Soo (Exercise Metabolism Laboratory, Department of Physical Education, Kyungpook National University)
Kang, Ho-Youl (Exercise Metabolism Laboratory, Department of Physical Education, Kyungpook National University)
Publication Information
The Korea Journal of Herbology / v.30, no.2, 2015 , pp. 37-42 More about this Journal
Abstract
Objectives : The aim of this study was to investigate the effects of licorice supplementation on muscle injury, plasma cortisol, testosterone and insulin sensitivity after high intensity resistance exercise. Methods : The fourteen health college male students were voluntarily participated in this study and were randomly divided into 2 groups: Control group (CON, n=7), Licorice group (LR, n=7). LR group ingested 2 g/time of licorice extract (mixed with 100 ml of water) two times/day for 10 days while the CON group ingested 100 ml of water. All subjects performed a high intensity resistance exercise (half-squat, 8 RM at 80% one-repetition maximum, 5 sets, 1min rest). Blood samples were collect before (-7) and after (0) licorice supplementation, and then 1 day, 2 day and 3 day post exercise. After 10 day treatment, plasma creatine kinase, cortisol, testosterone, glucose, insulin were measured. To determine the insulin sensitivity, HOMA-IR was calculated. Results : Plasma creatine kinase activities were significantly elevated after exercise, but there was not different between two groups. The plasma cortisol and testosterone levels were not significantly different between two groups. Plasma glucose levels were increased at 1 day and 2 day after exercise in the LR comparing with CON group (P<0.05) but plasma insulin levels were significantly lower in comparison with CON. HOMA-IR were significantly lower in the LR than CON group at 0 day to 3 day (P<0.05). Conclusions : The results of the current study suggest that licorice supplementation for 10 days might not attenuate the high-intensity exercise-induce muscle injury but may enhance the whole-body insulin sensitivity.
Keywords
licorice; muscle injury; resistance exercise; insulin sensitivity;
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1 Han MH, Lee MH, Hong SH, Choi YH, Moon JS, Song MK, Kim MJ, Shin SJ, Hwang HJ. Comparison of Anti-inflammatory Activities among Ethanol Extracts of Sophora flavescens, Glycyrrhiza uralensis and Dictamnus dasycarpus, and their Mixtures in RAW 246.7 Murine. J Life Sci. 2014 ; 24(3) : 329-35.   DOI   ScienceOn
2 Wu F, Jin Z, Jin J. Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. Mol Med Rep. 2013 ; 7(4) : 1278-82.   DOI
3 Clarkson PM, Hubal MJ. Exercise-induced muscle damage in humans. Am J Phys Med Rehabil. 2002 ; 81(11 Suppl) : S52-69.   DOI   ScienceOn
4 Camus G, Deby-Dupont G, Deby C, Juchmes-Ferir A, Pincemail J, Lamy M. Inflammatory response to strenuous muscular exercise in man. Mediators Inflamm. 1993 ; 2(5) : 335-42.   DOI   ScienceOn
5 Weight LM, Alexander D, Jacobs P. Strenuous exercise: analogous to the acute-phase response. Clin Sci (Lond). 1991 ; 81(5) : 677-83.   DOI
6 Nosaka K, Clarkson PM. Changes in indicators of inflammation after eccentric exercise of the elbow flexors. Med Sci Sports Exerc. 1996 ; 28(8) : 953-61.   DOI
7 Wojcik JR, Walber-Rankin J, Smith LL, Gwazdauskas FC. Comparison of carbohydrate and milk-based beverages on muscle damage and glycogen following exercise. Int J Sport Nutr Exerc Metab. 2001 ; 11(4) : 406-19.   DOI
8 Jang YS, Kang HY. Effects of exercise volume on plasma human growth hormone, testosterone and cortisol secretions during resistance exercise. Kor J Phys Educ. 2003 ; 42(2) : 429-37.
9 Willoughby DS, VanEnk C, Taylor L. Effects of concentric and eccentric contractions on exercise-induced muscle injury, inflammation, and serum IL-6. J Exerc Physiol. 2003 ; 6(4) : 8-15.
10 Narayan AR, Huang YC, Zhang YH, Li XM, Frieri M. Chinese herbal extract Glycyrrhiza uralensis (Gu), in the absence or presence of IL-1 beta, decreases nitrite production and proliferation of human type II alveolar epithelial cells (A549). J Allergy Clin Immunol. 2006 ; 117(2) : S156.   DOI   ScienceOn
11 Smilios I, Pilianidis T, Karamouzis M, Tokmakidis SP. Hormonal responses after various resistance exercise protocols. Med Sci Sports Exerc. 2003 ; 35(4) : 644-54.   DOI   ScienceOn
12 Willoughby DS, Taylor M, Taylor L. Glucocorticoid receptor and ubiquitin expression after repeated eccentric exercise. Med Sci Sports Exerc. 2003 ; 35(12) : 2023-31.   DOI   ScienceOn
13 Azimov MM, Zakirov UB, Radzhapova Sh D. [Pharmacological study of the anti-inflammatory agent glyderinine]. Farmakol Toksikol. 1988 ; 51(4) : 90-3.
14 Armanini D, Bonanni G, Palermo M. Reduction of serum testosterone in men by licorice. N Engl J Med. 1999 ; 341(15) : 1158.   DOI   ScienceOn
15 Kim KR, Jeong CK, Park KK, Choi JH, Park JH, Lim SS, Chung WY. Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice. J Biomed Biotechnol. 2010 ; 2010 : 709378.
16 Armanini D, Fiore C, Mattarello MJ, Bielenberg J, Palermo M. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes. 2002 ; 110(6) : 257-61.   DOI   ScienceOn
17 Armanini D, Bonanni G, Mattarello MJ, Fiore C, Sartorato P, Palermo M. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes. 2003 ; 111(6) : 341-3.   DOI   ScienceOn
18 Armanini D, Mattarello MJ, Fiore C, Bonanni G, Scaroni C, Sartorato P, Palermo M. Licorice reduces serum testosterone in healthy women. Steroids. 2004 ; 69(11-12) : 763-6.   DOI   ScienceOn
19 Zamansoltani F, Nassiri-Asl M, Sarookhani MR, Jahani-Hashemi H, Zangivand AA. Antiandrogenic activities of Glycyrrhiza glabra in male rats. Int J Androl. 2009 ; 32(4) : 417-22.   DOI   ScienceOn
20 Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiologica Hungarica. 2011 ; 98(2) : 221-30.   DOI
21 Ryu MS, Kim EH, Chun MS, Kang SH, Shim BS, Yu YB, Jeong GJ, Lee JS. Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk. J Ethnopharmacol. 2008 ; 115(2) : 184-93.   DOI   ScienceOn
22 Smith LL, Anwar A, Fragen M, Rananto C, Johnson R, Holbert D. Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise. Eur J Appl Physiol. 2000 ; 82(1-2) : 61-7.   DOI
23 Peake JM, Nosaka KK, Suzuki K. Characterization of inflammatory responses to eccentric exercise in humans. Exerc Immunol Rev. 2005 ; 11 : 64-85.
24 Peake JM, Nosaka KK, Muthalib M, Suzuki K. Systemic inflammatory responses to maximal versus submaximal lengthening contractions of the elbow flexors. Exerc Immunol Rev. 2006 ; 12 : 72-85.
25 Pedersen BK. IL-6 signalling in exercise and disease. Biochem Soc Trans. 2007 ; 35(Pt 5) : 1295-7.   DOI   ScienceOn
26 Nakagawa K, Kishida H, Arai N, Nishiyama T, Mae T. Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice. Biol Pharm Bull. 2004 ; 27(11) : 1775-8.   DOI   ScienceOn
27 Ha S, Lee HK, Seo DI. Effects of Peony-Licorice Mixture Supplementation on Blood Glucose and Lactate Levels. Kor J Herbology. 2012 ; 27(5) : 93-7.   DOI   ScienceOn
28 Gu HS. Theoretical Review on Biopharmacological Efficacy of Glycyrrhizae Radix. Dongeui Univ. 2005.
29 Mae T, Kishida H, Nishiyama T, Tsukagawa M, Konishi E, Kuroda M, Mimaki Y, Sashida Y, Takahashi K, Kawada T, Nakagawa K, Kitahara M. A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats. J Nutr. 2003 ; 133(11) : 3369-77.   DOI