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http://dx.doi.org/10.6116/kjh.2015.30.2.19.

Haeae-tang including Artemisia argyi Folium promotes hair growth in hair-removed C57BL/6 Mice  

Kim, Nam Hee (Sch. of Beauty Culture & Cosmetics, Dongju Coll.)
Moon, Sun Hee (Dept. of Public Health, Daegu Haany Univ.)
Kim, Mi Ryeo (BK21 Plus (TSKMI) Team and Dept. of Herbal Pharmacology, Daegu Haany Univ.)
Lee, Young Sun (Suseong Coll.)
Yoo, Wang Keun (Dept. of Health Science, Daegu Haany Univ.)
Publication Information
The Korea Journal of Herbology / v.30, no.2, 2015 , pp. 19-24 More about this Journal
Abstract
Objectives : The experiment was performed to investigate promotive effects of haeae-tang (HET) extract, a traditional Korean medicinal recipe, on hair growth, protein and gene expression in hair-removed C57BL/6. Methods : In experiment, animals were divided into 3 groups including normal (vehicle), HET ethanol extract and 5% minoxidil-treated groups (Minoxidil, positive control). The vehicle or testing samples were daily treated with 0.2ml per on hair-shaved dorsal skin of C57BL/6mice for 15 days. Effects of testing samples on hair growth was monitored through phototrichogram analysis by folliscope on the initial, $5^{th}$, $10^{th}$, $15^{th}$ day, respectively. Also, gene and protein expressions of vascular endothelial growth factor (VEGF) and Insulin like growth factor-1 (IGF-1), relevant to hair growth, were examined. Results : Hair density and hair thickness of Minoxidil treated-group was significantly increased compared to that of vehicle application on the $15^{th}$day, respectively. Dorsal hair density of HET treated-group was significantly increased compared to that of vehicle application on the $15^{th}$day. In addition, the Minoxidil group significantly increased the expression of cutaneous IGF-1 protein and mRNA compared to that of the vehicle-applied group on the $15^{th}$ day. And HET-treated group significantly increased the expression of dorsal VEGF protein compared to that of the vehicle-applied group on the $15^{th}$ day. Conclusions : These results suggest that this Korean medicinal recipe, HET has promoting activity on hair growth in an Alopecia animal model thus it can be used as a material of agent or products for improvement or prevention of alopecia.
Keywords
Haeae-tang; alopecia model; Hair growth; IGF-1; VEGF;
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Times Cited By KSCI : 2  (Citation Analysis)
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