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http://dx.doi.org/10.6116/kjh.2014.29.6.15.

Protective effects of Commiphora myrrha on acute pancreatitis  

Kim, Dong-Goo (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Bae, Gi-Sang (Hanbang Body-fluid Research Center, Wonkwang University)
Choi, Sun Bok (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Jo, Il-Joo (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Shin, Joon-Yeon (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Lee, Sung-Kon (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Kim, Myoung-Jin (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Kim, Min-Jun (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Choo, Gab-Chul (Department of Forest Resources, Gyeongnam national university of science and technology)
Song, Ho-Joon (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Park, Sung-Joo (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Publication Information
The Korea Journal of Herbology / v.29, no.6, 2014 , pp. 15-20 More about this Journal
Abstract
Objectives : Commiphora myrrha (CM) has been used in traditional medicine for treating disease such as obesity, hyperlipidemia, atherosclerosis, diabetes and osteoarthritis. However, the protective effects of CM on acute pancreatitis (AP) has not been reported. Thus, the aim of this study was to evaluate the protective effects of CM water extract on cerulein-induced AP. Methods : AP was induced in mice via intraperitoneal injection of supramaximal concentrations of the stable cholecystokinin analogue cerulein ($50{\mu}g/kg$) every hour for 6 times. Water extract of CM (0.1, 0.2, or 0.5 g/kg) was administrated intraperitoneally 1 h prior to the first injection of cerulein. The mice were killed at 6 h after the final cerulein injection. Pancreas was rapidly removed for morphologic and histochemical examination, myeloperoxidase (MPO) assay. Blood samples were taken to determine serum amylase and lipase activities. Results : Administration of CM significantly inhibited pancreatic weight/body weight ratio, pancreas histological injury. And CM administration inhibited the serum digestive enzyme elevation such as amylase and lipase on cerulein-induced pancreatitis. In addition, Pancreas MPO activity which indicates neutrophil infiltration was inhibited by CM extract on cerulein-induced pancreatitis. Conclusions : In conclusion, our results could suggest that pre-treatment of CM reduces the severity of cerulein-induced AP. Therefore, CM could be used as a protective agent against AP. Also, this study could give a clinical basis that CM could be a drug or agent to prevent AP.
Keywords
Commiphora myrrha; Acute pancreatitis; Cerulein; Amylase; Lipase;
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