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http://dx.doi.org/10.6116/kjh.2014.29.6.103.

Effect of Ecklonia cava Extracts Supplementation on cognitive ability in mice  

Oh, Jae-Keun (Institute of sports medicine and science, Korea National Sport Univ.)
Song, Ki-Jae (Institute of sports medicine and science, Korea National Sport Univ.)
Ji, Mu-Yeop (Institute of sports medicine and science, Korea National Sport Univ.)
Yoon, Jin-Ho (Dept. of sports and Leisure Studies, Far East Univ.)
Publication Information
The Korea Journal of Herbology / v.29, no.6, 2014 , pp. 103-109 More about this Journal
Abstract
Objectives : The purpose of this study aimed to investigate that dieckol - isolated from Ecklonia cava - supplementation can improve cognitive ability in mice. Methods : 48-male mice(6 weeks old) were divided into four groups; High-Dieckol group(n=12), Low-Dieckol group(n=12), Placebo group(n=12), Control group(n=12) and they were administered orally 5 days per week for 4 weeks at the same time. We performed Morris water maze test, Passive avoidance test, Blood serotonin analysis. And there was examined on neurogenesis in dentate gyrus of hippocampus using 5-bromo-2'-deoxyuridine (BrdU) to label proliferating cells. Results : The results are as follows; As a Morris water maze results, Trial duration was significantly decreased in high dieckol group comparing to placebo group and control group. Distance to target was significantly decreased in high dieckol group and low dieckol group comparing to placebo group and control group. Mean speed was significantly low in high dieckol group comparing to low dieckol group, placebo group and control group. As a Passive avoidance test results, latency time was significantly long in high dieckol group comparing to low dieckol group, placebo group and control group. BrdU cell count was significantly high in high dieckol group comparing to low dieckol group, placebo group and control group. Conclusions : As a conclusion, it is considered that dieckol supplementation might improve learning and cognitive ability.
Keywords
Ecklonia cava; Dieckol; Cognitive ability;
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