Browse > Article
http://dx.doi.org/10.6116/kjh.2014.29.6.1.

The influences of extraction time and pressure on the chemical characteristics of Gyejibokryeong-hwan decoctions  

Kim, Jung-Hoon (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine)
Lee, Nari (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine)
Shin, Hyeun-Kyoo (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine)
Seo, Chang-Seob (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine)
Publication Information
The Korea Journal of Herbology / v.29, no.6, 2014 , pp. 1-6 More about this Journal
Abstract
Objectives : This study was aimed to compare Gyejibokryeong-hwan (GBH) decoctions produced using different pressure levels for various extraction times to find the optimal extraction conditions through extraction yield, total soluble solids content (TSSC), hydrogen ion concentration (pH), and the contents of chemical compounds. Methods : Decoctions of GBH were prepared under the pressure levels of 0 or $1kgf/cm^2$ for 30-180 min using water as extraction solvent. The extraction yield, TSSC, and pH were measured, and the amounts of the chemical compounds were determined using high performance liquid chromatography-photodiode array detector. Results : The higher pressure and longer extraction time increased the values of TSSC and extraction yield, while decreased the pH value. The decoctions produced in 180 min by pressurized method and produced in 150 min by non-pressurized method showed maximum values of extraction yield and TSSC with minimum value of pH. The amounts of chemical compounds showed variations in pressurized and non-pressurized decoction during overall extraction times. The influences of pressure and extraction time on extraction yield, TSSC, pH, and the contents of chemical compounds were confirmed by regression analysis, which showed that all extraction values were significantly affected by at least one of two extraction factors, pressure and extraction time. Conclusions : This study suggests that the pressure and extraction time can significantly affect the extraction efficiency of components from GBH decoctions. However, optimal extraction conditions could not be chosen due to the variation of the amounts of chemical compounds.
Keywords
Gyejibokryeong-hwan; extraction factor; extraction yield; total soluble solids content; chemical compounds; regression analysis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Zhang S, Chen R, Wu H, Wang C. Ginsenoside extraction from Panax quinquefolium L. (American ginseng) root by using ultrahigh pressure. J Pharm Biomed Anal. 2006 ; 41(1) : 57-63.   DOI   ScienceOn
2 Sakamoto S, Yoshino H, Shirahata Y, Shimodairo K, Okamoto R. Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas. Am J Chin Med. 1992 ; 20(3-4) : 313-7.   DOI   ScienceOn
3 Sang H. Clinical and experimental research into treatment of hysteromyoma with promoting qi flow and blood circulation, softening and resolving hard lump. J Traditi Chin Med. 2004 ; 24(4) : 274-9.
4 Ushiroyama T, Ikeda A, Sakuma K, Ueki M. Comparing the effects of estrogen and an herbal medicine on peripheral blood flow in post-menopausal women with hot flashes: hormone replacement therapy and gui-zhi-fu-ling-wan, a Kampo medicine. Am J Chin Med. 2005 ; 33(2) : 259-67.   DOI   ScienceOn
5 Egizabal A, Zuloaga O, Etxebarria N, Fernandez LA, Madariaga JM. Comparison of microwave-assisted extraction and Soxhlet extraction for phenols in soil samples using experimental designs. Analyst. 1998 ; 123 : 1679-84.   DOI   ScienceOn
6 Choi MP, Chan KK, Leung HW, Huie CW. Pressurized liquid extraction of active ingredients (ginsenosides) from medicinal plants using non-ionic surfactant solutions. J Chromatogr A. 2003 ; 983(1-2) : 153-62.   DOI   ScienceOn
7 Kwak EJ. Development of brown colored rice tea with high GABA content. J Korean Soc Food Sci Nutr. 2010 ; 39(8) : 1201-5.   과학기술학회마을   DOI   ScienceOn
8 Eikani MH, Golmohammad F, Rowshanzamir S. Subcritical water extraction of essential oils from coriander seeds (Coriandrum sativum L.). J Food Eng. 2007 ; 80(2) : 735-40.   DOI   ScienceOn
9 Luthria DL. Influence of experimental conditions on the extraction of phenolic compounds from parsley (Petroselinum crispum) flakes using a pressurized liquid extractor. Food Chemistry. 2008 ; 107(2) : 745-52.   DOI   ScienceOn
10 Kaufmann B, Christen P. Recent extraction techniques for natural products: Microwave-assisted extraction and pressurised solvent extraction. Phytochem Anal. 2002 ; 13(2) : 105-13.   DOI   ScienceOn
11 Prasad KN, Yang B, Shi J, Yu C, Zhao M, Xue S, Jiang Y. Enhanced antioxidant and antityrosinase activities of longan fruit pericarp by ultra-high-pressure-assisted extraction. J Pharm Biomed Anal. 2010 ; 51(2) : 471-7.   DOI   ScienceOn
12 Kim SH, Kim HK, Yang ES, Lee KY, Kim SD, Kim YC, Sung SH. Optimization of pressurized liquid extraction for spicatoside A in Liriope platyphylla. Sep Purif Technol. 2010 ; 71(2) : 168-72.   DOI   ScienceOn
13 Liu B, Guo F, Chang Y, Jiang H, Wang Q. Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical $CO_2$. JChromatogr A. 2010 ; 1217(50) : 7833-9.   DOI   ScienceOn
14 Corrales M, Toepfl S, Butz P, Knorr D, Tauscher B. Extraction of anthocyanins from grape by-products assisted by ultrasonics, high hydrostatic pressure or pulsed electric fields: A comparison. Inno Food Sci Emerg Technol. 2008 ; 9(1) : 85-91.   DOI   ScienceOn
15 Prasad KN, Yang E, Yi C, Zhao M, Jiang Y. Effects of high pressure extraction on the extraction yield, total phenolic content and antioxidant activity of longan fruit pericarp. Innov Food Sci Emerg Technol. 2009 ; 10(2) : 155-9.   DOI   ScienceOn
16 Ramamoorthy PK, Bono A. Antioxidant activity, total phenolic and flavonoid content of Morinda citrifolia fruit extracts from various extraction processes. J Eng Sci Technol. 2007 ; 2(1) : 70-80.
17 Rostagno MA, Palma M, Barroso CG. Ultrasound-assisted extraction of isoflavones from soy beverages blended with fruit juices. Anal Chim Acta. 2007 ; 597(2) : 265-72.   DOI   ScienceOn
18 Chu K, Chen L, Xu Wei, Li H, Zhang Y, Xie W, Zheng J. Preparation of a paeonol-containing temperature-sensitive in situ gel and its preliminary efficacy on allergic rhinitis. Int J Mol Sci. 2013 ; 14(3) : 6499-515.   DOI   ScienceOn
19 Wang R, Wang R, Yang B. Extraction of essential oils from five cinnamon leaves and identification of their volatile compound compositions. Innov Food Sci Emerg Technol. 2009 ; 10(2) : 289-92.   DOI   ScienceOn
20 Zhong K, Wang Q. Optimization of ultrasonic extraction of polysaccharides from dried longan pulp using response surface methodology. Carbohydr Polym. 2010 ; 80(1) : 19-25.   DOI   ScienceOn