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http://dx.doi.org/10.6116/kjh.2013.28.4.25.

Hepatoprotective Effects of Hovenia dulcis Extract on Acute and Chronic Liver Injuries induced by Alcohol and Carbon Tetrachloride  

Kim, Young-Sik (Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.)
Park, Juyeon (Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.)
Kwon, Yongbeom (Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.)
Lim, Dong Wook (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
Song, MiKyung (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
Choi, Ho-Young (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
Kim, Hocheol (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
Publication Information
The Korea Journal of Herbology / v.28, no.4, 2013 , pp. 25-32 More about this Journal
Abstract
Objectives : The purpose of this study was to evaluate the hepatoprotective effect of Hovenia dulcis extract on acute and chronic liver injuries induced by alcohol and $CCl_4$ in mice and rats. Methods : In acute alcohol-induced liver injury, mice were administered Hovenia dulcis extracts (60 and 200 mg/kg) orally before and after alcohol administration. In chronic alcohol-induced liver injury, mice were administered alcohol containing liquid diet for 4 weeks. The mice were administered H. dulcis extracts (60 and 200 mg/kg) mixed with the liquid diet. In acute $CCl_4$-induced liver injury, rats received a single dose of $CCl_4$ (2 mL/kg in olive oil, intraperitoneally). Rats were administered H. dulcis extracts (30, 100 and 300 mg/kg) before and after $CCl_4$ administrations. After the ends of the administrations, the serum levels of AST and ALT were measured using chemical analyzer, and ${\gamma}$-GTP levels were measured using spectrophotometer. Results : In acute alcohol-induced liver injury, H. dulcis extracts treated group showed significant reduction in ALT levels compared to those of control group. In chronic alcohol-induced liver injury, it inhibited weight-loss compared to normal group and showed significant reduction in AST, ALT and ${\gamma}$-GTP levels compared to control group. In acute $CCl_4$-induced liver injury, it also showed significant reduction in AST, ALT levels compared to control group. Conclusions : The results show that H. dulcis extract has hepatoprotective effect in acute and chronic alcohol-induced liver injury and acute $CCl_4$-induced liver injury. These findings suggest that H. dulcis could be a potent hepatoprotective agent.
Keywords
Hovenia dulcis; hepatoprotective effect; carbon tetrachloride; alcohol; liver;
Citations & Related Records
Times Cited By KSCI : 15  (Citation Analysis)
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