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http://dx.doi.org/10.6116/kjh.2013.28.2.55.

Inhibitory Effects of Chestnut Inner Shell Cytokine Production from Human Mast Cell Line  

Jun, Dong-Ha (Department of Cosmeceutical Science, Daegu Haany University)
Jang, Young-Ah (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Hui-Yeong (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Su-Jin (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Jin-Chul (THURINGEN KOREA Co., Ltd)
Kim, Sea-Hyun (Korea Forest Research Institute)
Kwoen, Dae-Jun (Biohealth convergence Center, Technopark)
Han, Sang-Ik (Department of Functional Crop, National Institute of Crop Science)
Lee, Jin-Tae (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
The Korea Journal of Herbology / v.28, no.2, 2013 , pp. 55-60 More about this Journal
Abstract
Objectives : Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous inflammtion of the skin. The chestnut inner shell extracts (CI) has been used as a cosmetic material for a long time in Korea. However, the precise anti-allergy effects of CI have yet to be clearly elucidated. In this study, we attempted to evaluate the effect of CI on mast cell-mediated allergy inflammation. Methods : To find the anti-allergy and inflammatory effect of CI, we investigated the inhibitory effect of CI on the production of inflammatory mediators using by enzyme-linked immunosorbent assay in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187) stimulated-human mast cell (HMC-1). Results : In this study, we found that CI did not show cytotoxic effect at up to 10 ug/ml on HMC-1. CI inhibited the production of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6 and IL-8 in stimulated HMC-1. Maximal rate of TNF-${\alpha}$, IL-6 and IL-8 inhibition by CI (10 ug/ml) were about 47.6%, 44.1% and 22.5% respectively. In addition, we showed that Fr.3 isolated from n-Butyl alcohol layer of CI attenuated the production of TNF-${\alpha}$, IL-6 and IL-8 in HMC-1. Conclusion : Taken together, the findings of this study provide us with a novel insight action of CI as a potential molecule for use in the treatment of allergic inflammation diseases.
Keywords
Chestnut Inner Shell; HMC-1; Inflammatory cytokine; Allergy;
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Times Cited By KSCI : 2  (Citation Analysis)
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