Browse > Article
http://dx.doi.org/10.6116/kjh.2012.27.5.9

Protective effect of Poncirus trifoliata and Citrus aurantium extract on acute pancreatitis in mice model  

Park, Kyoung-Chel (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
Bae, Gi-Sang (Hanbang Body-fluid Research Center, Wonkwang University)
Choi, Sun-Bok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
Jo, Il-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
Gwak, Tae-Sin (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
Lee, Guem-San (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
Publication Information
The Korea Journal of Herbology / v.27, no.5, 2012 , pp. 9-14 More about this Journal
Abstract
Objective : We investigated the effect of Poncirus trifoliata and Citrus aurantium extract in mice with cerulein-induced acute pancreatitis (AP) model. Methods : AP was induced via intraperitoneal injection of cerulein (50 ${\mu}g/kg$) given every hour for 6h. Poncirus trifoliata (PT: 200 or 400 mg/kg) and Citrus aurantium (CA: 200 or 400 mg/kg) extract were injected 1 h before in mice with cerulein-induced AP. Mice were sacrificed at 6 h after last injection of cerulein. Blood samples were taken to determine serum amylase and lipase levels. The pancreas and lungs were rapidly removed for morphological examination, myeloperoxidase assay. Results : PT pre-treatment significantly protected the pancreas and lung damages and reduced the MPO activity and serum amylase in cerulein-induced AP. However, CA pre-treatment did not significantly protected the pancreas and lung inflammation in cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP.
Keywords
Poncirus trifoliata (PT); Citrus aurantium (CA) Acute pancreatitis (AP); Amylase; Cerulein;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Ban SS, Yoon HD, Shin OC, Shin YJ, Park CS, Park JH, Seo BI. The Effects of Artemisiae Capillaris, Ponciri Fructus and Cartaegi Fructus in Obese Rats Induced by High Fat Diet. Kor J Herbology. 2006 ; 21(2) : 55-67.
2 Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, Chevali L. Pathoph ysiology of acute pancreatitis. Pancreatology. 2005 ; 5(3) : 132-44.   DOI   ScienceOn
3 Lane JS, Todd KE, Gloor B, Chandler CF, Kau AW, Ashley SW, Reber HA, McFadden DW. Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. J Surg Res. 2001 ; 99 : 365-70.   DOI   ScienceOn
4 Granger J, Remick D. Acute pancreatitis : models, markers, and mediators. Shock. 2005 ; 24(1) : 45-51.   DOI   ScienceOn
5 Gea-Sorli S, Guillamat R, Serrano-Mollar A, Closa D. Activation of lung macrophage subpopulations in experimental acute pancreatitis. J Pathol. 2011 ; 223(3) : 417-24.   DOI   ScienceOn
6 Bhatia M. Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol. 2004 ; 202(2) : 145-56.   DOI   ScienceOn
7 Pateghini M. Pagani F. Bonora R. Clinical and analytical evaluation of a continuos enzymatic method for measuring pancreatic lipase activity. Clin Chem. 1993 ; 39 : 304-8.
8 Mosby international Ltd. Crash course-Immune, Blood and Lymphatic Systems. Korea : Publishing Hanwoori. 2000 ; 17-9.
9 Park SJ, Jeong JG, Seo SW, Hwang SW, Kim YW, Song DS, Chae YS, Shin MK, Song HJ. Inhibitory Effect of Aacute Pancreatitis by Patriniae Herba. Kor J Herbology. 2005 ; 20(3) : 93-100.
10 Lee HT, Seo EK, Chung SJ, Shim CK. Effect of an aqueous extract of dried immature fruit of Poncirus trifoliata (L.) Raf. on intestinal transit in rodents with experimental gastrointestinal motility dysfunctions. J Ethnopharmacol. 2005 ; 102 : 302-6.   DOI   ScienceOn
11 Shin MK. Clinical Herbalogy. Korea : Youngrimsa. 2000 : 819-21.
12 Ham IH, Lee UC, Lee BH, Choi HY. Lipid Lowering activity of Ponciri Fructus and Aurantii Fructus Immaturus on hyperlipemia rats induced by Triton WR-1339. Kor J Herbology. 2007 ; 22(3) : 109-16.
13 Kurt J. Harrison's principles of internal medicine. Korea : Jungdam. 1997 : 1637.
14 Nam DH, Nam JK, Dong HK, Whang GY. Abstracts of the 21st Annual Convention. Studies on the Anti - inflammatory Constituents of Ponciri Fructus. Kor J Pharmacogn. 1991 ; 22(1) : 64
15 Kim SJ, Park SK. Antioxidative and Anti-inflammatory Effects of Aurantii Fructus Immaturus Pharmacopuncture. Korean Journal of Acupuncture. 2010 ; 27(2) : 13-24.
16 Dep of Internal Medcine Seoul National Unversity. SNUH Manual of Medicine. Seoul : Korea Medicine Book. 2005 : 128-35.
17 Bradley EL 3rd. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis. Arch surg. 1993 ; 128(5) : 586-90.   DOI
18 Steer ML. Frank Brooks memorial lecture : the early intra acinar cell events which occur during acute pancreatitis. Pancreas. 1998 ; 17 : 31-7.   DOI   ScienceOn
19 Lim JH, Kim HS, Choi EJ, Shim CK, Park HJ. Effects of Poncirus fructus on Gastrointestinal Motility in Guinea Pig : in vitro and in vivo Study. Journal of Neurogastroenterology and Motility. 2008 ; 14 : 7-17.
20 Kim CD. Pathogenesis of Acute Pancreatitis. Kor J Gastroenterol. 1997 : 11-5.
21 Lee HS. Experimental animal models of pancreatic disease. Kor J Gastroenterol Seminar. 2002 : 144-51.
22 Choi WS. Inhibitory Effects of Rhizoma Curcumae Longae on The Cerulein-induc ed Acute Pancreatitis in Mice. Graduate School of Wonkwang University. 2008.
23 Chae YS. The inhibitory effect of Fructus Gardeniae in cerulein induced acute pancreatitis. Graduate School of Wonkwang University. 2009.
24 Song JM. Inhibitory effect of Nardostachys chinensis B_(ATAL) on pancreatitis. Graduate School of Wonkwang University. 2009.
25 Park JS, Choi CW. The Effect of SuJeom-san on Caerulein-induced Acute Pancreatitis in Rats. Kor J Orient Int Med. 2010 ; 31(3) : 500-12.
26 Kim JH. Effect of Lonicerae Flos Water Extract on Cerulein-induced Acute Pancreatitis in Rats. Graduate School of Dongshin University. 2009.
27 Kim BK, Joo JS, Kim JS, Jeong JG. Study of Efficacy of Foeniculi Fructus and Lonicerae Flos Extract on Acute Pancreatitis. Kor J Herbology. 2010;25(4):39-45.