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http://dx.doi.org/10.6116/kjh.2012.27.4.1

Effects of KOB, a polyherbal medicine for allergic rhinitis and its main herb, Astragali Radix on allergic responses in OVA-induced Allergic rhinitis mice  

Kang, Seok-Yong (Department of Herbology, College of Oriental Medicine, Dongguk University)
Hong, Seung-Ug (Department of Oriental Medicine Ophthalmology & Otolaryngology & Dermatology, College of Oriental Medicine, Dongguk University Ilsan Oriental Hospital)
Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
Publication Information
The Korea Journal of Herbology / v.27, no.4, 2012 , pp. 1-7 More about this Journal
Abstract
Objectives : In this study, we investigated the effect of KOB, a polyherbal medicine for allergic rhinitis and its main herb, Astragali Radix on allergic responses in ovalbumin (OVA)-induced Allergic rhinitis(AR) mice. Methods : Sprague Dawley (SD)-rats were orally administrated with KOB (500 mg/kg), Astragali Radix water extract (ARW, 100 mg/kg) or anti-histamine drug, dosodium cromoglycate (50 mg/kg) as a reference drug, and then intraperitoneally injected with compound 48/80 (8 mg/kg). Rats were measured the mortality and serum levels of histamine. BALB/c mice were orally administrated with KOB (500 mg/kg), ARW (100 mg/kg) or anti-histamine drug, Ketotifen (10 mg/kg) as a reference drug, followed by sensitization and challenge of OVA. Mice were measured the serum levels of histamine and IgE, and observed histopathological changes of nasa mucosa H&E staining. Results : KOB and ARW significantly decreased the mortality and the serum levels of histamine in compound 48/80-induced anaphylatic rats. KOB and ARW also decreased the serum levels of histamine and IgE in OVA-induced AR mice, and inhibited histopathological changes of nasal mucosa with inflammation and the eosinophils infilteration. Conclusions : These data suggest that KOB has a strong anti-allergic effect through the inhibitory property of Astragali Radix, the main component of KOB against allergic responses in allergic rhinitis.
Keywords
Astragali Radix; KOB; anti-allergic effect; Allergic rhinitis; anaphylaxis;
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Times Cited By KSCI : 10  (Citation Analysis)
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