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http://dx.doi.org/10.6116/kjh.2012.27.3.83

Effects of Dendrobii herba against Intracerebral Hemorrhage in Rats  

Lee, Jung-Dong (Department of Anatomy-Pointology, College of Oriental Medicine, Gachon University)
Kim, Youn-Sub (Department of Anatomy-Pointology, College of Oriental Medicine, Gachon University)
Publication Information
The Korea Journal of Herbology / v.27, no.3, 2012 , pp. 83-88 More about this Journal
Abstract
Objects : This study was performed in order to observe the effects of water extract of Dendrobii herba on intracerebral hemorrhage(ICH), Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. After the water extracts of Dendrobii herba were administrated orally once a day for 3 days, hematoma volume, percentage of brain edema, expression of iNOS and MPO were observed using immunohistochemistry. Results : Rats fed with water extracts of Dendrobii herba showed reduction of hematoma volume and percentage of brain edema compared with controls. In addition, Infiltration of myeloperoxidase (MPO) expressing neutrophil and expression of inducible nitric oxide synthatase(iNOS) were significantly reduced in rats fed with water extracts of Dendrobii herba. Conclusion : These results demonstrated that water extracts of Dendrobii herba reduced brain damage of intracerebral hemorrhage(ICH) and subsequent ICH-induced cerebral edema, and inhibited neutrophil infiltration.
Keywords
Dendrobii herba(DH); ICH; iNOS; MPO; Brain Edema;
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