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http://dx.doi.org/10.6116/kjh.2012.27.3.75

Comparitive study on anti-asthmatic activities of Patrinia scabiosaefolia Fischer ex Link and Patrinia villosa Jussieu in a mouse model of asthma  

Cha, Jong-Tae (Department of Herbology, College of Oriental Medicine, Sangji University)
Lee, Jang-Cheon (Division of Pharmacology and Basic Korean Medicine, School of Korean Medicine, Pusan National University)
Lee, Young-Cheol (Department of Herbology, College of Oriental Medicine, Sangji University)
Publication Information
The Korea Journal of Herbology / v.27, no.3, 2012 , pp. 75-82 More about this Journal
Abstract
Objective : In the present study, we investigated the pharmacological profile of the aqueous extract of $Patrinia$ $scabiosaefolia$ Fischer ex Link (EPS) and $Patrinia$ $villosa$ Jussieu (EPV) for its anti-asthmatic activities. The purpose of this study is to ascertain if EPS result in better anti-asthmatic activities and functional outcome as compared with EPV. Methods : In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally, intraperitoneally, and by aerosol allergen challenges. We investigated the effect of EPS, EPV on the recruitment of pulmonary inflammatory cells, various immune cell phenotypes, Th1/Th2 cytokine gene expression and production and histamine production in serum. Results : In BALB/c mice, we found that EPV-treated groups had more effectively suppressed inflammatory cell infiltration of lung and BALF, B220+IgE+, CD11b+Gr-1+ cell population in lung and these occurred by suppressing the gene expression of IL-4, IL-5 and IL-4 cytokine production in BALF and serum. Conclusions : These results suggest that EPV may play an important role in the control of anti-asthmatic activities by down-regulation of Th2 cytokine (especially IL-4, IL-5). In general, EPV has shown a better anti-asthmatic activities compared to EPS.
Keywords
Patrinia scabiosaefolia Fischer ex Link (EPS); Patrinia villosa Jussieu (EPV); asthma; IL-4; IL-5;
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1 Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony-Lafontaine J, Godard P, et al. Eosinophilic inflammation in asthma. N Engl J Med. 1990 ; 323(15) : 1033-9.   DOI   ScienceOn
2 Marzio R, Mauel J, Betz-Corradin S. CD69 and regulation of the immune function. Immunopharmacol Immunotoxicol. 1999 ; 21(3) : 565-82.   DOI
3 Yachie A, Toma T, Miyawaki T, Taniguchi N. Expression of surface CD11b antigen and eosinophil activation. Nippon Rinsho. 1993 Mar ; 51(3) : 593-7.
4 Fleming TJ, Fleming ML, Malek TR. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J Immunol 1993 ; 151 : 2399-408.
5 Marsland BJ, Le Gros G. CD8+ T cells and immunoregulatory networks in asthma. Springer Semin Immunopathol. 2004 ; 25(3-4) : 311-23.   DOI   ScienceOn
6 Shalaby KH, Martin JG. Overview of asthma; the place of the T cell. Curr Opin Pharmacol. 2010 ; 10(3) : 218-25.   DOI   ScienceOn
7 Romagnani S. T-cell responses in allergy and asthma. Current Opinion in Allergy and Clinical Immunology 2001 ; 1(1) : 73-8.   DOI
8 Al Heialy S, McGovern TK, Martin JG. Insights into asthmatic airway remodelling through murine models. Respirology. 2011 ; 16(4) : 589-97.   DOI   ScienceOn
9 Wang J, Homer RJ, Chen Q, Elias JA. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. J Immunol. 2000 ; 165(7) : 4051-61.   DOI
10 Xie Y, Peng J, Fan G, Wu Y. Chemical composition and antioxidant activity of volatiles from Patrinia Villosa Juss obtained by optimized supercritical fluid extraction. J Pharm Biomed Anal. 2008 Nov4 ; 48(3) : 796-801. Epub 2008 Aug 14.   DOI   ScienceOn
11 Lim JK, Roh SS, Kil KJ, Lee YC, Seo YB. The Study of Duchesnea chrysanta Inhibition Blocks Airway Inflammation in a OVA-induced Asthma mouse Model. Korea J Herbol. 2005 ; 20(1) : 73-83.
12 Zhang T, Li Q, Li K, Li Y, Li J, Wang G, Zhou S. Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer. Phytother Res. 2008 May ; 22(5) : 640-5.   DOI   ScienceOn
13 Phillip Factor. Gene Therapy for Asthma. Mol Ther. 2003 ; 7(2) : 148-52.   DOI   ScienceOn
14 Kim YK, Kwon JN, Mun MG. The Investigation between Oriental and Western Medicine on Cause for Asthma. Thesis collection of Oriental Medical Research center of Dong-Eui University. 2000 ; 12 : 85-105.
15 Schwartz DA, Thorne PS, Jagielo PJ, White GE, Bleur SA, Frees KL. Endotoxin responsiveness and grain dust-induced inflammation in the lower respiratory tract. Ame J Physiol. 1994 ; 267 : 609-17.
16 Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C. A Critical Role for Eosinophils in Allergic Airways Remodeling. Science. 2004 ; 305 : 1776-9.   DOI   ScienceOn
17 Boushey HA. New and Exploratory Therapies for Asthma. Chest. 2003 ; 12 3 : 439-45.
18 Lukacs NW. Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol. 2001 ; 1(2) : 108-16.   DOI   ScienceOn
19 Pene J, Rousset F, Brière F, Chretien I, Wideman J, Bonnefoy JY, De Vries JE. Interleukin 5 enhances interleukin 4-induced IgE production by normal human B cells. The role of soluble CD23 antigen. Eur J Immunol. 1988 ; 18(6) : 929-35.   DOI   ScienceOn
20 Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008 Mar ; 8(3) : 183-92.   DOI   ScienceOn
21 Cho EJ, Shin JS, Noh YS, Cho YW, Hong SJ, Park JH, Lee JY, Lee JY, Lee KT. Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis. J Ethnopharmacol. 2011 ; 136(3) : 428-35.   DOI   ScienceOn
22 The textbook compilation committee of Korean herbology. Korean herbology. Seoul : Younglimsa. 2010 : 255-256.
23 English-Chinese collegiate textbooks in traditional chinese medicine for institutions of traditional chinese medicine of higher learning edited by Beijing University of Traditional Chinese Medicine. The Chinese Materia Medica. Beijing : Xue Yuan Academy Press. 1998 ; 78, 422.
24 Seo SW, Park CS, Hong SH, Kwon KB, Moon HC, Song BK, Kim KY, Park YM, Song HJ, Kim HM, Park SJ. Inhibitory effect of Patrinia scabiosaefolia on acute pancreatitis. World J Gastroenterol. 2006 ; 12(7) : 1110-4.   DOI
25 Lee EJ, Kim C, Kim JY, Kim SM, Nam D, Jang HJ, Kim SH, Shim BS, Ahn KS, Choi SH, Jung SH, Ahn KS. Inhibition of LPS-induced inflammatory biomarkers by ethyl acetate fraction of Patrinia scabiosaefolia through suppression of NF-$\kappa B$ activation in RAW 264.7 cells. Immunopharmacol Immunotoxicol. 2012 Apr ; 34(2) : 282-91.   DOI   ScienceOn
26 Peng J, Chen Y, Lin J, Zhuang Q, Xu W, Hong Z, Sferra TJ. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Mol Med Report. 2011 ; 4(2) : 313-8.
27 Li N, Zhao B, Yu YF, Dong XP. Studies on anti-inflammation chemical constitutes of Patrinia villosa. Zhong Yao Cai. 2008 ; 31(1) : 51-3.
28 Lee SY, In KH. Immunopathogenesis of Asthma. Tuberc Respir Dis. 2006 ; 60(4) : 379-390   과학기술학회마을   DOI   ScienceOn