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http://dx.doi.org/10.6116/kjh.2012.27.2.69

Mountain cultivated ginseng water boiled extract decreases blood glucose level and improves lipid metabolism in male db/db mice  

Kim, Eung-Lae (Woori Institute of Mountain Cultivated Ginseng)
Kim, Chang-Sik (Woori Institute of Mountain Cultivated Ginseng)
Lee, Hee-Young (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University)
Lee, Hye-Rim (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University)
Kim, Eung-Yeol (Kongju Communication Arts University)
Yoon, Mi-Chung (Dept. of Life Sciences, Mok-Won University)
Shin, Soon-Shik (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University)
Publication Information
The Korea Journal of Herbology / v.27, no.2, 2012 , pp. 69-75 More about this Journal
Abstract
Objectives : We investigated the effects of mountain cultivated ginseng water boiled extract(MCG) on blood glucose and insulin levels, and examined whether lipid metabolism are improved by it in male db/db mice(a murine model of type 2 diabetes mellitus). Methods : 9 weeks old, male db/db mice were divided into 5 groups : C57BL/6J normal, control, MCG-250mg/kg (MCG-1), MCG-500mg/kg(MCG-2) and MCG-1000mg/kg(MCG-3). After mice were treated with MCG for 8 weeks, we measured body weight, food intake, fat weight, visceral organ weight and blood glucose, insulin and lipid levels. Results : 1. We found no difference in body weight, food intake, fat weight and visceral organ weight among the animal groups. 2. Compared with controls, MCG-treated mice had lower blood glucose level and higher blood insulin levels, the magnitude of which was prominent in MCG-2. 3. Compared with controls, MCG-treated mice had lower LDL-cholesterol and higher HDL-cholesterol levels. 4. Compared with controls, MCG-treated mice had blood triglyceride and free fatty acid levels, the magnitude of which was prominent in MCG-2. 5. Blood AST and ALT concentrations were not changed by MCG, indicating MCG do not show any toxic effects. Conclusions : These results demonstrate that MCG effectively increases blood insulin level and decreases blood glucose level, blood lipid levels, and prevents and improves diabetic dyslipidemia and cardiovascular disease.
Keywords
mountain cultivated ginseng(MCG); diabetes; glucose; triglyceride; insulin; dyslipidemia;
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Times Cited By KSCI : 10  (Citation Analysis)
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