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http://dx.doi.org/10.6116/kjh.2012.27.1.11

Effects of pear ethanol extract on asthma induced by ovalbumin in mice  

Chung, Hee-Jin (School of Korean medicine, Pusan National University)
Joung, Young-Min (School of Korean medicine, Pusan National University)
Choi, Eu-Gene (School of Korean medicine, Pusan National University)
Shin, Dong-Sung (School of Korean medicine, Pusan National University)
Kim, Hyung-Woo (School of Korean medicine, Pusan National University)
Cho, Su-In (School of Korean medicine, Pusan National University)
Publication Information
The Korea Journal of Herbology / v.27, no.1, 2012 , pp. 11-16 More about this Journal
Abstract
Objectives : In the theory of Korean medicine, Pear has long been considered to protect throat, bronchus and lung. Pear has been believed to remove sputum in Korean people. This study was conducted to investigate the effect of pear ethanol extract (PEE) on asthma induced by ovalbumin in mice. Methods : We investigated the effects of PEE on airway hyperresponsiveness to methacholine, production levels of ovalbumin (OVA) specific total immunoglobulin G (IgG), IgG1, IgG2a and IgE in serum and histopathological changes of lung tissues in asthamtic mice. Results : PEE decreased airway hyperresponsiveness to methacholine significantly compared to non-treated asthmatic mice (P<0.05). Level of OVA specific IgE in serum was lowered by oral administration of PEE effectively (P<0.05). In histopathological observation, administration of PEE reduced infiltration of immune cells into lung tissue. Conclusion : These results suggest that pear has anti-asthmaitc action and related mechanims are involved in anti-inflammatory action such as reducing level of OVA specific IgE and immune cell infiltration.
Keywords
Pear; IgE; airway hyperresponsiveness; anti-inflammation; Asthma;
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1 Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I. Role of IgE in Th2 cell-mediated allergic airway inflammation. Int. Arch. Allergy Appl. Immunol. 2003;131(1):2-6.   DOI   ScienceOn
2 Dhar S, Malakar R, Chattopadhyay S, Dhar S, Banerjee R, Ghosh A. Correlation of the severity of atopic dermatitis with absolute eosinophil counts in peripheral blood and serum IgE levels. Indian J Dermatol Venereol Leprol. 2005;71(4):246-249.   DOI
3 Ho Joo Yoon. Treatment Guideline of Bronchial Asthma. Tuberculosis and Respiratory Diseases. 2006;60(6):601-607.   DOI   ScienceOn
4 Bohadana AB, Teculescu DB, Megherbi SE, Pham QT. Bronchial hyperresponsiveness in farmers: relation to respiratory symptoms, lung function, and atopy. Lung 1999;177:191-201.   DOI   ScienceOn
5 Young Il Kim, Inseon S. Choi, Dong Jin Park, Yeon Joo Kim, Dae Ho Cho, Soo Yeong Jee, Joon Seok Choi, Eui Ryoung Han. Etiologic Factors for Methacholine Upper Airway Hyperresponsiveness and Upper Airway Obstruction. Asthma and allergy 2010;30(1):21-29.
6 Hargreave FE, Ryan G, Thomson NC, O'Byrne PM, Latimer K, Juniper EF, et al. Bronchial responsiveness to histamine or methacholine in asthma:measurement and clinical significance. J Allergy Clin Immunol 1981;68:347-55.   DOI
7 Gun Ha Kim, Kang Jin Seo, Jung Hye Byeon, Dae Jin Song, Young Yoo, Ji Tae Choung, Young Yull Koh. Changes in Bronchial Hyperresponsiveness in Children with Asthma. Pediatr. Allergy Respir. Dis. (Korea). 2007;17(3):196-205.
8 Ochiai K, Wang B, Rieger A, Kilgus O, Maurer D, Fodinger D, Kinet J, Stingl G, Tomioka H. A review on Fc epsilon RI on human epidermal Langerhans cells. Int Arch Allergy Immunol. 1994;104(1):63-64.   DOI   ScienceOn
9 Marshall BG, Wilkinson RJ, Davidson RN. Pathogenesis of tropical pulmonary eosinophilia: parasitic alveolitis and parallels with asthma. Respir Med. 1998;92(1):1-3.   DOI   ScienceOn
10 Ulinska D, Szmidt M. Usefulness of the eosinophil count in induced sputum of asthmatic patients. Pneumonol Alergol Pol. 2001;69(9-10):581-589.
11 Balzar S, Strand M, Rhodes D, Wenzel SE. IgE expression pattern in lung:relation to systemic IgE and asthma phenotypes. J Allergy Clin Immunol. 2007 Apr;119(4):855-862.   DOI   ScienceOn
12 Martin TR, Takeishi T, Katz HR, Austen KF, Drazen JM, Galli SJ. Mast cell activation enhances airway responsiveness to methacholine in the mouse. J. Clin. Invest. 1993;91:1176-1182.   DOI   ScienceOn
13 Hamelmann E, Cieslewicz G, Schwarze J, Ishizuka T, Joetham A, Heusser C, Gelfand EW. Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 1999;160:934-941.   DOI   ScienceOn
14 Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I. Role of IgE in Th2 cell-mediated allergic airway inflammation. Int Arch Allergy Immunol. 2003;131:2-6.   DOI   ScienceOn
15 Kwang-Sik Cho, Sam-Seok Kang, Hyeon-Mo Cho, Gab-Cheon Koh, Kyung-Hy Hong, Dong-Soo Son, Whee-Cheon Kim, Ki-Youl Kim. Breeding of a Very Soft, Juicy, Large Sized, and High Quality Mid-season Pear Cultivar 'Manpungbae'. Korean journal of horticultural science & technology. 2003;21(1):25-28.
16 Chen Guiyan. Bonchogangmoktongseok. Peiching: Hakwon publishing company 1992:1449-1450.
17 Lee JC, Pak SC, Lee SH, Na CS, Lim SC, Song CH, Bai YH, Jang CH. Asian pear pectin administration during pre-sensitization inhibits allergic response to ovalbumin in BALB/C mice. J Altern Complement Med. 2004;10(3):527-534.   DOI   ScienceOn
18 Chang Su Na, Dae Hwan Youn, Dong Hee Choi, Jong Gil Jeong, Jong Bang Eun, Jeong Sang Kim. The Effect of Pear Pectin &. Phenolic Compounds on Regional Cerebral Blood Flow, Mean Arterial Blood Pressure, Heart Rate and Cardiac Contractile Force in Hypertensive Rat Induced by 2K1C. Kor. J. Herbology 2003;18(2):101-108.
19 Na Chang Su, Yun Dae Hwan, Choi Dong Hee, Kim Jeong Sang, Cao Chun Hua, Eun Jong Bang. The Effect of Pear Pectin on Blood Pressure, Plasma Renin, ANP and Cardiac Hypertrophy in Hypertensive Rat Induced by 2K1C. J. Korean Soc. Food Sci. Nutr. 2003;32(5):700-705.   DOI   ScienceOn
20 Kim Jeong Sang, Na Chang Su, Effect of Rehmanniae Radix and Pear Phenolic Compound on the STZ-Treated Mice for Induction of Diabetes. J. Korean Soc. Food Sci. Nutr. 2004;33(1):66-71.   DOI   ScienceOn
21 Chang Su Na, Jong Gil Jeong, Dae Hwan Youn. The effects of pear phenolic compound and herbal drugs on tension of the tracheal smooth muscle, eosinophil and interleukin-4 in mouse model of allergic bronchial asthma induced by ovalbumin. Kor. J. Herbology 2007;22(2):25-33.
22 Young Min Joung, Hyung Woo Kim, Hee Jin Chung, Eu Gene Choi, Yoon Ho Do, Jeong Sik Choi, Su In Cho. Effects of Pear Alcoholic Fermentation Beverage on Airway Hyperresponsiveness and Immunoglobulin Production in Asthmatic Mice. Kor. J. Herbology 2009;24(4):107-113.
23 Sugita M, Kuribayashi K, Nakagomi T, Miyata S, Matsuyama T, Kitada O. Allergic bronchial asthm a:airway inflammation and hyperresponsiveness. Intern Med. 2003;42(8):636-643.   DOI   ScienceOn
24 Kao ST, Wang SD, Wang JY, Yu CK, Lei HY. The effect of Chinese herbal medicine, xiao-qing-long tang (XQLT ), on allergen-induced bronchial inflammation in mite-sensitized mice. Allergy. 2000;55:1127-1133.   DOI   ScienceOn
25 Kurt J. lsselbacher et al. Harrison's principles of internal medicine. 13th ed. Seoul:Jung Dam. 1997:1258.