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http://dx.doi.org/10.6116/kjh.2012.27.1.1

The effect of Gihyeolgwanjeolbang-A(CWS-A) on adjuvant-induced arthritis in rats  

Na, Chang-Su (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University)
Youn, Dae-Hwan (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University)
Kim, Jeong-Sang (Dept. of Anatomy, Oriental Medical School, Dongshin University)
Chae, Woo-Seok (Dept. of Acupuncture, Oriental Medical School, Dongshin University)
Publication Information
The Korea Journal of Herbology / v.27, no.1, 2012 , pp. 1-10 More about this Journal
Abstract
Objective : To investigate effects of herbal preparations formulated(Gihyeolgwanjeolbang-A, CWS-A) on complete Freund's adjuvant (CFA)-induced arthritis in rats. Method : Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw, and the herbal preparations formulated(CWS-A I, 82.3 mg/kg ; CWS-A II, 164.6 mg/kg) was administered orally (i.g.) for 10 consecutive days beginning on day 10 after the injection. External shape, paw edema, inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), and histological observation were assessed. Result : In swelling of the paw, CWS-A I and CWS-A II group in 15 days and 20 days were significantly reduced compared to controls. In serum ALT, CWS-A I and CWS-A II group were significantly reduced compared to controls. In TNF-${\alpha}$, CWS-A I and CWS-A II group were a tendency reduced compared to controls. In HGB, HCT, MCHC of erythrocytes, CWS-A II group was increased compared to controls. In histological observations, CWS-A II group was observed synoviocytes more than control group and was observed proteoglycans in the deep layers. Conclusion : The data suggest that CWS-A significant anti-arthritic effects that may be mediated by suppressing inflammatory parameters.
Keywords
Arthritis; complete Freund's adjuvant (CFA); herbal preparations; serum and blood parameters; histological observation;
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Times Cited By KSCI : 4  (Citation Analysis)
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