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http://dx.doi.org/10.6116/kjh.2011.26.4.083

The Experimental study on the Immuno-regultory effect of Notopterygii Rhizoma Extract on OVA-induced asthma in mice  

Yoo, Ji-Hyun (International Ginseng and Herb Research Institute Geumsan)
Bae, Jin-Hyun (Department of Herbal Pharmaceutical Science, Joongbu University)
Doh, Eun-Soo (Department of Herbal Pharmaceutical Science, Joongbu University)
Chang, Jun-Pok (Department of Herbal Pharmaceutical Science, Joongbu University)
Seong, Nak-Sul (International Ginseng and Herb Research Institute Geumsan)
Kil, Ki-Jung (Department of Herbal Pharmaceutical Science, Joongbu University)
Publication Information
The Korea Journal of Herbology / v.26, no.4, 2011 , pp. 83-88 More about this Journal
Abstract
Objectives : The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of Notopterygii Rhizoma(NR) extract on OVA(ovalbumin)-induced asthma in mice. Methods : C57BL/6 mice out of all the experimental groups, except the Normal group and the NRI group, were sensitized and challenged with OVA. C57BL/6 mice were exposed to OVA three times a week for 12 weeks and analyzed by flow cytometer, ELISA, H&E stain. Results : The concentrations of IL-4, IL-5, IL-13, IgE in serum of the OVA-NRII group decreased significantly compared with those of the OVA-Control group. The number of $Gr-1^+/CD11b^+$, $CCR3^+$, $CD3^+/CD19^+$, $CD3e^+/CD69^+$cells in the OVA-NRI group decreased significantly compared with those of the OVA-Control group. The collagen accumulation in the lung sections of the OVA-NRII group decredased signi- ficantly compared with that of the OVA-Control group. Conclusions : These results suggest that Notopterygii Rhizoma(NR) would be a effective candidate for herbal-originated anti-asthmatic drug. However, this drug should be further studied for characterization of the accurate action and underlying mechanism using variant disease model in the future.
Keywords
Notopterygii Rhizoma; OVA(ovalbumin)-induced asthma; immune cell;
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Times Cited By KSCI : 7  (Citation Analysis)
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