Study on Antiangiogenic Effect of Black Ginseng Radix
![]() |
Song, Gyu-Yong
(College of Pharmacy, Chungnam National University)
Chung, Kyu-Jin (College of Pharmacy, Chungnam National University) Shin, Young-Jin (College of Pharmacy, Chungnam National University) Lee, Gye-Won (Department of Pharmaceutical Engineering, Konyang University) Lee, Sook-Young (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) Seo, Young-Bae (Department of Herbalogy, College of Oriental Medicine, Daejeon University) |
1 | Kim LS, MacDonald NJ, Gubich ER. Angiostatin and Endostatin:Endogenous Inhibitors of Tumor Growth. Cancer and metastasis reviews. 2000;19(1):181-190. DOI |
2 | Lee MR, Yun BS, Sun BS, Liu L, Zhang, DL, Wang CY, Wang Z, Ly SY, Mo EK, Sung CK. Change of ginsenoside Rg3 and acetylcholinesterase inhibition of black ginseng manufactured by grape juice soaking. J Gineng Res. 2009;33(4):349-354. DOI |
3 | Lee MR, Yun BS, Liu L, Zhang DL, Wang Z, Wang CL, Gu LJ, Wang CY, Mo EK, Sung CK. Effect of black ginseng on memory improvement in the amnesic mice induced by scopolamine. J Ginseng Res. 2010;34(1):51-58. DOI |
4 | Kim HJ, Lee, JY, You BR, Kim HR, Choi JE, Nam KY et al. Antioxidant activities of ethanol extracts from black ginseng prepared by steaming-drying cycles. J Korean Soc Food Sci Nutr. 2011;40(2):156-162. DOI |
5 | Kim AJ, Kang SJ, Lee KH, Lee MS, Ha SD, Cha YS, Kim SY. The chemopreventive potential and anti-inflammatory activities of Korean black ginseng in colon26-M3.1 carcinoma cells and macrophages. J Korean Soc Appl Biol Chem. 2010;53(1):101-105. |
6 | Grant DS, Kinsella JL, Fridman R, Auerbach R, Piasecki BA, Yamada Y, Zain M, Kleinman HK. Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo. J Cell Physiol. 1992;153:614-25. DOI |
7 | Liu L, Zhu XM, Wang QJ, Zhang DL, Fang ZM, Wang CY, Wang Z, Sun BS, Wu H, Sung CK. Enzymatic preparation of 20(S,R)-protopanaxadiol by transformation of 20(S,R)-Rg3 from black ginseng. Phytochemistry. 2010;71(13):1514-1520. DOI ScienceOn |
8 | Sun BS, Gu LJ, Fang ZM, Wang CY, Wang Z, Sung CK. Determination of 11 ginsenosides in black ginseng developed from Panax ginseng by high performance liquid chromatography. Food Science and Biotechnology. 2009;18(2):561-564. |
9 | Nguyen HT, Yang SY, Kim JA, Song GY, Kim YH. Dammarane-type saponins from the black ginseng. Bulletin of the Korean Chemical Society. 2010;31(11):3423-3426. DOI |
10 |
Reynolds AR, Reynolds LE, Nagel TE, Lively JC, Robinson SD, Hicklin DJ, Bodary SC, Hodivala-Dilke KM. Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in |
11 | Boyd D. Invasion and metastasis. Cancer Metastasis Rev. 2006;15(1):77-89. |
12 | Jost LM, Kirkwood JM, Whiteside TL. Improved short- and long-term XTT-based colorimetric cellular cytotoxicity assay for melanoma and other tumor cells. J Immunol Methods. 1992;147:153-165. DOI ScienceOn |
13 | Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins.Identification by morphologic and immunologic criteria. J Clin Invest. 1973;52:2745-2756. DOI ScienceOn |
14 | Huh JE, Baek YH, Lee JD, Choi DY, Park DS. Screening and mechanism study of angiogenesis in many herbs medicine. The journal of Korean Acupuncture & Moxibustion Society. 2007;24(5):23-32. |
15 | Plate KH, Breier G, Risau W. Molecular mechanisms of developmental and tumor angiogenesis. Brain Pathol. 1994;4:207-18. DOI ScienceOn |
16 | Ha YW, Lim SS, Ha IJ, Na YC, Seo JJ, Shin H, Son SH, Kim YS. Preparative isolation of four ginsenosides from Korean red ginseng (steam-treated Panax ginseng C. A. Meyer), by high-speed countercurrent chromatography coupled with evaporative light scattering detection. Journal of Chromatography, A. 2007;1151(1):37-44. DOI ScienceOn |
17 | Song YS, Kim SH, Sa JH, Jin C, Lim CJ, Park EH. Anti-acngiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus. J. Ethnopharmacol. 2003;88:113-116. DOI ScienceOn |
18 | Kim JS, Park BY, Park EK, Lee HS, Hahm JC, Bae KH, Kim MY. Screening of Anti-angiogenic Activity from Plant Extracts. Korean Journal of Pharmacognosy. 2006;37(4):253-257. |
19 | Lee KH, Choi HR. Kim CH. Anti-angiogenic effect of the see extract of Benincasa hipida Cogniaux. J. Ethnophamacol. 2005;97:509-513. DOI ScienceOn |
20 | Nam NH, Kim HM, Bae KH. Ahn BZ. Inhibitory effects of Vietnamese medicinal plants on tubelike formation of human umbilical venous cells. Phytother.Res. 2003;17:107-111. DOI ScienceOn |
21 | Bergers G, Benjamin L. Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer. 2002;3:401-410. |
22 | Folkman J. Angiogenesis and apoptosis. Semin. Cancer Biol. 2003;3:159-167. |
23 | Kim EK, LEE JH, Cho SH, Shen GN, Jin LG, Myung CS, Oh HJ, Kim DH, Yun JD, Roh SS, Park YJ, Seo YB, Song GY. Preparation of black panax ginseng by new methods and its antitumor activity. The Korea Journal Herbology. 2008;23(1):85-92. |
24 | Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249-57. DOI ScienceOn |
25 | Folkman J, Siegel Y. Angiogenesis. J Biol Chem. 1992;267:10931-10934. |
26 | Song GY, Ph HJ, Roh SS, Seo YB, Park YJ, Myung CS. Effect of black ginseng on body weight and lipid profiles in male rats fed normal diets. Yakhak Hoeji. 2006;50:381-385. |
27 | Kim Y. Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana. Planta Med. 2003;68(3):271-274. |
28 | Chen MW, Ni L, Zhao XG, Niu XY. The inhibition of 20(R)-ginsenoside Rg3 on the expressions of angiogenesis factors proteins in human lung adenocarcinoma cell line A549 and HUVEC304 cell. Zhongguo Zhong Yao Za Zhi. 2005;30(5):357-60. |
29 | Griffioen AW, Molema G. Angiogenesis:potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 2000;52(2):237-68. |
30 | Lee JH, Shen GN, Kim EK, Shin HJ, Myung CS, Oh HJ, Kim DH, Roh SS, Cho W, Seo YB, Park YJ, Kang CW, Song GY. Preparation of black ginseng and its antitumor activity. 2006;20(4):951-956. |
31 | Folkman J. Tumor angiogenesis:therapeutic implications. N. Engl. J. Med. 1971;285:1182-1186. DOI ScienceOn |
32 | Keum YS, Park KK, Lee JM, Chun KS, Park JH, Lee SK, Kwon H, Surh YJ. Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett. 2000;150:41-48. DOI ScienceOn |
33 | Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN. The angiosuppressive effects of 20(R)-ginsenoside Rg3. Biochem Pharmacol. 2006;72(4):437-45. DOI ScienceOn |
34 | Lee SI. The history of Korean ginseng 2nd. Samhwa press. 1980:166. |
35 | Yue PY, Wong DY, Ha WY, Fung MC, Mak NK, Yeung HW, Leung HW, Chan K, Liu L, Fan TP, Wong RN. Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro. Angiogenesis. 2005;8(3):205-16. DOI ScienceOn |
36 | Yu LC, Chen SC, Chang WC, Huang YC, Lin KM, Lai PH, Sung HW. Stability of angiogenic agents, ginsenoside Rg1 and Re, isolated from Panax ginseng:in vitro and in vivo studies. Int J Pharm. 2007;328(2):168-76. DOI ScienceOn |
![]() |