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http://dx.doi.org/10.6116/kjh.2011.26.2.059

Effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on Corticotropin-Releasing Factor, c-Fos, and Tyrosine Hydroxylase in Forced Swimming Test  

Sim, Eun-Yeong (Formulae Pharmacology Dept. School of Oriental Medical School, Kyungwon University)
Lee, Tae-Hee (Formulae Pharmacology Dept. School of Oriental Medical School, Kyungwon University)
Publication Information
The Korea Journal of Herbology / v.26, no.2, 2011 , pp. 59-66 More about this Journal
Abstract
Objectives : The goal of this study was to investigate the antidepressant effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on the change of HPA-Axis and Catecholamic system. Methods : We were performed the Forced Swimming Test. The expressions of Corticotropin-Releasing Factor (CRF) and c-Fos at paraventricular nucleus (PVN), and tyrosine hydroxylase (TH) at ventral tegmental area (VTA) and locus coeruleus (LC) were evaluated by immunohistochemical method. Results : The duration of immobility in the Forced Swimming Test was significantly decreased in A100, A400(p<0.05~p<0.01). CRF expressions at PVN was significantly decreased in A400(p<0.05).No other group showed significant difference in expression of c-Fos at PVN comparing with control group. TH expressions at VTA was significantly decreased in A100 and A400, respectively(p<0.001). TH expressions at LC was significantly decreased in A100(p<0.01). Conclusions : According to the above results, Mixture of Lycii Radicis Cortex and Moutan Cortex has antidepressant effects via the reduction of CRF expression and the Catecholamine System activity.
Keywords
Lycii Radicis Cortex; Moutan Cortex; FST; CRF; c-Fos; PVN; TH; VTA; LC;
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Times Cited By KSCI : 7  (Citation Analysis)
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