Molecular biologic mechanism of obesity by GGEx18 |
Lee, Hee-Young
(Dept. of Formula Science, College of Oriental Medicine and Research Institute of Oriental Medicine, Dongeui University)
Yoon, Ki-Hyeon (Dept. of Formula Science, College of Oriental Medicine and Research Institute of Oriental Medicine, Dongeui University) Seo, Bu-Il (Department of Oriental Herbology, Daegu Haany University) Park, Gyu-Ryeol (Department of Oriental Herbology, Daegu Haany University) Yoon, Mi-Chung (Dept. of Life Sciences, Mokwon University) Shen, Zhi-Bin (Dept. of Chemistry and Analysis of Traditional Chinese Medicine, College of Chinese Materia Medica, Guangdong Pharmaceutical University) Cui, Hong-Hua (Dept. of Chemistry and Analysis of Traditional Chinese Medicine, College of Chinese Materia Medica, Guangdong Pharmaceutical University) Shin, Soon-Shik (Dept. of Formula Science, College of Oriental Medicine and Research Institute of Oriental Medicine, Dongeui University) |
1 | Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, et al. PPAR alpha and PPAR gamma activators direct a distinct tissue-specific transcriptional response via a PPRE in lipoprotein lipase gene. EMBO J. 1996 ; 15 : 5336-48. |
2 | Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med. 2004 Apr ; 10(4) : 355-361. DOI ScienceOn |
3 | Tontonoz P, Hu E, Graves R, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonist and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem 1996 ; 39 : 665-68. DOI ScienceOn |
4 | Hagen T, Zhang CY, Slieker LJ, Chung WK, Leibel RL, Lowell BB. Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system. FEBS Lett 1999 ; 454 : 201-206. DOI ScienceOn |
5 | Rosen E.D. et al. PPAR is required for differentiation of adipose tissue in vivo and in vitro. Mol. Cell 1999 ; 4 : 611-7. DOI ScienceOn |
6 | Braissant O, Foufelle F, Scotto C, et al. Differential expression of peroxisome proliferatoractivated receptors (PPARs) : tissue distribution of PPAR-alpha, -beta, and gamm in the adult rat. Endocrinology 1996 ; 137 : 354-66. DOI ScienceOn |
7 | Auboeuf D, Rieusset J, Fajas L, et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver receptor alpha in humans. Diabetes 1997 ; 46 : 1319-27. DOI ScienceOn |
8 | Linton, M.F., Fazio, S.K. Re-emergence of fibrates in the management of dyslipidemia and cardiovascular risk. Curr. Atheroscler. 2000 ; Rep 2 : 29-35. DOI ScienceOn |
9 | Kopelman PG. Obesity as a medical problem. Nature. 2000 Apr 6 ; 404(6778) : 635-43. |
10 | 윤기현, 이희영, 정양삼, 서부일, 박규열, 윤미정, 신순식. Ob/Ob 마우스에서 輕身降脂丸의 비만조절. 大韓本草學會誌 2010 ; 25(3) : 1-9. |
11 | Zurlo, F., Larson, K., Bogardus, C, & Ravussin, E.. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J. Clin. Invest. 1990 ; 86 : 1423-1427. DOI |
12 | Fleury C. Neverova M, Collins S et al. Uncoupling protein 1 : A novel gene linked to obesity and hyperinsulinemia. Nat Genet 1997 ; 15 : 269-272. DOI |
13 | Baumruk F, Flachs P, Horakova M, Floryk D, Kopecky J.. Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential. FEBS Lett 1999 ; 444 : 206-210. DOI |
14 | Evas D, Minouchehr S, Hagemann G et al. Frequency of and interaction between polymorphisms in the beta 3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans. Int J Obes 2000 ; 24 : 1239-1245. DOI |
15 | Bukwoiecki, L.J., Follea, N., Lupien, J. & Paradis, A.. Metabolic relationships between lipolysis and respiration in rat brown adipocytes. The role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis. J. Biol. Chem. 1981 ; 256 : 12840-12848. |
16 | Elbein SC, Leppert M, Hasstedt S. Uncoupling protein 2 region in chromosome 11q13 is not linked to markers of obesity in familial type 2 diabetes. Diabetes 1997 ; 46 : 2105-2107. DOI |
17 | Enerback, S., Jacobsson, A., Simpson, E.M., Guerra, C., Yamashita, H., M.E. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 1997 ; 387 : 90-94. DOI ScienceOn |
18 | C.B. Chan, P.E. MacDonald, M.C. Saleh, D.C. Johns, E. Marban, M.B. Wheeler. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 1999 ; 48 : 1482-1486. DOI ScienceOn |
19 | Cusin, I et al. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes. 1998 ; 249 : 107-110. |
20 | Himms-Hagen, J.. Brown adipose tissue thermogenesis and obesity. Prog. Lipid. Res. 1989 ; 28 : 67-115. DOI ScienceOn |
21 | Collins, S et al. Role of leptin in fat regulation. Nature 1996 ; 380 : 677. DOI ScienceOn |
22 | Oliver et al. A selective peroxisome proliferator-activated receptor agonist promotes reverse cholesterol transport. Proc. Natl. Acad. Sci. USA. 1999 ; 96 : 6102-6. DOI ScienceOn |
23 | Tontonoz P, Hu E, Devine J, et al. PPAR gamma2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol 1995 ; 15 : 351-7. DOI |
24 | Sfeir Z, Ibrahimi A, Amri E, et al. Regulation of FAT/CD36 gene expression : further evidence in support of a role of the protein in fatty acid binding/transport. Prostaglandins Leukot. Essent. Fatty Acids 1997 ; 57 : 17-21. DOI ScienceOn |
25 | Lowell, B.B. et al. Development of obesity in transgenic mice after genetic ablation brown adipose tissue. Nature 1993 ; 366 : 740-742. DOI ScienceOn |
26 | Winegar, D.A.. Effects of fenofibrate on lipid parameters in obese rhesus monkeys. J. Lipid. Res. 2001 ; 42 : 1543-51. |