Browse > Article
http://dx.doi.org/10.7181/acfs.2022.00612

Lacrimal sac lymphoma: a case report  

Ueathaweephol, Somtaporn (Department of Ophthalmology, Faculty of Medicine, Srinakharinwirot University)
Wongwattana, Panuwat (Department of Otolaryngology, Faculty of Medicine, Srinakharinwirot University)
Chanlalit, Waruttaporn (Department of Ophthalmology, Faculty of Medicine, Srinakharinwirot University)
Trongwongsa, Therdkiat (Department of Pathology, Faculty of Medicine, Srinakharinwirot University)
Sutthinont, Sirilak (Division of Hematology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University)
Publication Information
Archives of Craniofacial Surgery / v.23, no.1, 2022 , pp. 43-47 More about this Journal
Abstract
Primary lymphoma originating from the lacrimal drainage system is a rare disease. Such lymphomas are mostly B-cell in origin and present nonspecific symptoms. The treatment of malignant lymphoma of the lacrimal drainage system is slightly different. We present the case of a 71-year-old woman with a painless mass below the medial canthus. Computed tomography (CT) scan of the orbit revealed a mass invading the right lacrimal sac. An incision biopsy was obtained, and the pathologic findings suggested a diagnosis of primary diffuse large B-cell lymphoma of the lacrimal sac. The patient was treated with chemotherapy and intrathecal methotrexate. After completing eight cycles of chemotherapy, the patient was followed up by a CT scan, which revealed nearly total resolution of an ill-defined enhancing mass. At the time of this case report writing, the patient is in complete remission at six months with no other complications.
Keywords
Case reports; Diffuse large B-cell lymphoma; Nasolacrimal sac; Lacrimal sac; Lymphoma;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Erickson BA, Massaro BM, Mark LP, Harris GJ. Lacrimal collecting system lymphomas: integration of magnetic resonance imaging and therapeutic irradiation. Int J Radiat Oncol Biol Phys 1994;29:1095-103.   DOI
2 Tsao WS, Huang TL, Hsu YH, Chen N, Tsai RK. Primary diffuse large B cell lymphoma of the lacrimal sac. Taiwan J Ophthalmol 2016;6:42-4.   DOI
3 Kumar VA, Esmaeli B, Ahmed S, Gogia B, Debnam JM, Ginsberg LE. Imaging features of malignant lacrimal sac and nasolacrimal duct tumors. AJNR Am J Neuroradiol 2016;37:2134-7.   DOI
4 Venkitaraman R, George MK. Primary non Hodgkin's lymphoma of the lacrimal sac. World J Surg Oncol 2007;5:127.   DOI
5 Stefanyszyn MA, Hidayat AA, Pe'er JJ, Flanagan JC. Lacrimal sac tumors. Ophthalmic Plast Reconstr Surg 1994;10:169-84.   DOI
6 Sjo LD, Ralfkiaer E, Juhl BR, Prause JU, Kivela T, Auw-Haedrich C, et al. Primary lymphoma of the lacrimal sac: an EORTC ophthalmic oncology task force study. Br J Ophthalmol 2006;90:1004-9.   DOI
7 de Palma P, Ravalli L, Modestino R, Grisanti F, Casillo F, Marzola A. Primary lacrimal sac B-cell immunoblastic lymphoma simulating an acute dacryocystitis. Orbit 2003;22:171-5.   DOI
8 Palamar M, Midilli R, Ozsan N, Egrilmez S, Sahin F, Yagci A. Primary diffuse large B-cell lymphoma of the lacrimal sac simulating chronic dacryocystitis. Auris Nasus Larynx 2011;38: 643-5.   DOI
9 Jordan DR, Nerad JA. Diffuse large-cell lymphoma of the nasolacrimal sac. Can J Ophthalmol 1988;23:34-7.
10 Gao HW, Lee HS, Lin YS, Sheu LF. Primary lymphoma of nasolacrimal drainage system: a case report and literature review. Am J Otolaryngol 2005;26:356-9.   DOI
11 Montalban A, Lietin B, Louvrier C, Russier M, Kemeny JL, Mom T, et al. Malignant lacrimal sac tumors. Eur Ann Otorhinolaryngol Head Neck Dis 2010;127:165-72.   DOI
12 Sharara N, Holden JT, Wojno TH, Feinberg AS, Grossniklaus HE. Ocular adnexal lymphoid proliferations: clinical, histologic, flow cytometric, and molecular analysis of forty-three cases. Ophthalmology 2003;110:1245-54.   DOI
13 De Stefani A, Lerda W, Usai A, Cavalot A, Riella P, Bussi M. Squamous cell carcinoma of the lacrimal drainage system: case report and literature review. Tumori 1998;84:506-10.   DOI
14 Meunier J, Lumbroso-Le Rouic L, Vincent-Salomon A, Dendale R, Asselain B, Arnaud P, et al. Ophthalmologic and intraocular non-Hodgkin's lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors. Hematol Oncol 2004;22:143-58.   DOI
15 Zarrabi K, Desai V, Yim B, Gabig TG. Primary diffuse large B-cell lymphoma localized to the lacrimal sac: a case presentation and review of the literature. Case Rep Hematol 2016;2016: 5612749.
16 Keleti D, Flickinger JC, Hobson SR, Mittal BB. Radiotherapy of lymphoproliferative diseases of the orbit. Surveillance of 65 cases. Am J Clin Oncol 1992;15:422-7.
17 Saccogna PW, Strauss M, Bardenstein DS. Lymphoma of the nasolacrimal drainage system. Otolaryngol Head Neck Surg 1994;111:647-51.   DOI
18 Parmar DN, Rose GE. Management of lacrimal sac tumours. Eye (Lond) 2003;17:599-606.   DOI
19 Decaudin D, de Cremoux P, Vincent-Salomon A, Dendale R, Rouic LL. Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options. Blood 2006;108:1451-60.
20 Rasmussen PK, Ralfkiaer E, Prause JU, Sjo LD, Toft PB, Siersma VD, et al. Diffuse large B-cell lymphoma of the ocular adnexal region: a nation-based study. Acta Ophthalmol 2013;91:163-9.   DOI