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http://dx.doi.org/10.13066/kspm.2013.8.1.127

The Effects of Exercise of Diverse Intensities on the Recovery of Articular Cartilage in Osteoarthritic Rats  

Park, Soo-Jin (Department of Physical Therapy, Sunlin College)
Choi, Young-Chul (Department of Rehabilitation Science, Graduate School of Daegu University)
Kim, Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Daegu University)
Publication Information
Journal of the Korean Society of Physical Medicine / v.8, no.1, 2013 , pp. 127-135 More about this Journal
Abstract
PURPOSE: This study examined the effects of exercise of diverse intensities on the recovery of articular cartilage in osteoarthritic rats. METHODS: Over a period of four weeks, the authors applied treadmill exercise programs of diverse intensities to Sprague-Dawley rats, to which intra-articular injection of monosodium iodoacetate(MIA, 3mg/$50{\mu}l$, diluted in saline) was applied to the right knee joint to induce osteoarthritis. The four-week exercise program was not carried out with the control group(CG, n=10). Exercise programs of applicable intensities were applied to the low-intensity exercise group(LEG, n=10), moderate-intensity exercise group(MEG, n=10), and high-intensity exercise group(HEG, n=10) over the four weeks. Observations were made of morphological changes in the rats' articular cartilage, using hematoxylin and eosin stains. RESULTS: there were significant differences(p<.05) in the comparison of articular damage scores between the four groups involved. Articular cartilage damage scores were found to be significantly lower in the LEG, MEG, and HEG than in the CG, indicating that exercise helped with the recovery of cartilage. Of these latter three groups, the MEG showed the highest level of recovery, while the HEG showed the lowest. CONCLUSION: These study results suggest that exercise is effective in treating OA. They also indicate that in prescribing exercise to treat osteoarthritic patients, exercise of moderate intensity is most suitable to patients' physical conditions, rather than low or high intensity, maximizes, and so should be used to maximize the effects of therapy.
Keywords
Osteoarthritis; Articular cartilage; Exercise intensity;
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