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Effect of Low Frequency Electrical Stimulation on VEGF Expression of Suspension Induced Atrophic Muscle  

Kang, Jong-Ho (Department of Physical Therapy, Nambu University)
Han, Jong-Man (Department of Physical Therapy, Chunnam College)
Publication Information
Journal of the Korean Society of Physical Medicine / v.5, no.2, 2010 , pp. 273-280 More about this Journal
Abstract
Purpose : The purpose of this experiment was to evaluate the pre-application effect of low frequency electrical stimulation(LFES) on VEGF expression of atrophic muscle and to determine the optimal pre-application period of LFES for prevent muscle atropy Methods : Twenty-five adult sprague-dawley rats were randomly assigned to weight bearing group, hindlimb suspension for 14 days group, hindlimb suspension with pre-application of LFES for 14 days group, hindlimb suspension with pre-application of LFES for 11 dsys group and, hindlimb suspension with pre-application LFES for 7 dsys group. 16Hz of Biphasic pulse current was applied to gastrocnemius for 15min per days. Results : VEGF were decreased expression in HSG groups, whereas VEGF were significantly increased in HS+ES14G, HS+ES11G, HS+ES7G groups Conclusion : LFES during the hindlimb suspension showed a positive effect in VEGF induction and early application is strongly encourage VEGF induction. This indicated that pre-application of LFES could prevent muscle atrophy.
Keywords
Muscle atrophy; Low frequency electrical stimulation; Vascular endothelial growth factor;
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