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The Association of Nonalcoholic Fatty Liver Disease with Metabolic Syndrome  

Kim, Su-Yun (Department of Family Medicine, Ewha Womans University College of Medicine)
Lee, Hong-Soo (Department of Family Medicine, Ewha Womans University College of Medicine)
Lee, Sang-Hwa (Department of Family Medicine, Ewha Womans University College of Medicine)
Kim, Hai-Lim (Department of Family Medicine, Ewha Womans University College of Medicine)
Oh, Young-A (Department of Family Medicine, Ewha Womans University College of Medicine)
Sim, Kyung-Won (Department of Family Medicine, Ewha Womans University College of Medicine)
Publication Information
Korean Journal of Family Medicine / v.28, no.9, 2007 , pp. 667-674 More about this Journal
Abstract
The Association of Nonalcoholic Fatty Liver Disease with Metabolic SyndromeSu Yun Kim, M.D., Kyung Won Shim, M.D.†, Hong Soo Lee, M.D., Sang Hwa Lee, M.D., Hai Lim Kim, M.D., Young A Oh, M.D. Background: Recently, the diagnosis of non-alcoholic fatty liver disease (NAFLD) has been made more frequently, as the use of ultrasonography on health screening has been on the rise. The aim of this study was to elucidate the relationship between NAFLD and the metabolic syndrome defined by NCEP-ATP III criteria. Methods: A total of 1,675 subjects, who attended for routine physical check‐ups, were screened. Among those, 401 subjects were selected after excluding the subjects with either significant alcohol consumption, evidence of viral or toxic hepatitis, significant liver or renal dysfunction, or overt thyroid disease. NAFLD was diagnosed if the subjects had a “bright liver” on ultrasonographic examination. The diagnosis of metabolic syndrome was made according to the criteria of NCEP-ATP III established in 2001. Results: The prevalence of NAFLD was 27.2%. Blood pressure, body weight, body mass index, waist circumference, and serum levels of total cholesterol, triglyceride, fasting glucose and liver enzymes were higher among the subjects with NAFLD than the control. The prevalence of obesity, IFG/DM, dyslipidemia and hypertension was higher in the NAFLD group. The prevalence of the metabolic syndrome was 19.2%, which was higher in the NAFLD group than the control group. The odds ratio of NAFLD for the metabolic syndrome was 6.458 (95% C.I. 3.178∼13.124). Conclusion: NAFLD was closely associated with the metabolic syndrome regardless of the presence of obesity. (J Korean Acad Fam Med 2007;28:667-674)
Keywords
non-alcoholic fatty liver disease; metabolic syndrome; ultrasonography; obesity;
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1 Sheth SG, Gordon FD, Chopra S. Nonalcoholic steatohepatitis. Ann Intern Med 1997;126:137-45   DOI   ScienceOn
2 Leevy CM. Fatty liver: a study of 270 patients with biopsy proven fatty liver and review of the literature. Medicine 1962;41:249-76   DOI
3 Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001;50:1844-50   DOI   ScienceOn
4 Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287: 356-9   DOI   ScienceOn
5 Meigs JB. Epidemiology of the metabolic syndrome, 2002. Am J Manag Care 2002;8 Suppl 11:283-93
6 WHO. The Asia-Pacific perspective: redefining obesity and its treatment. 2000. Geneva
7 Nomura H, Kashiwagi S, Hayashi J, Kajiyama W, Tani S, Goto M. Prevalence of fatty liver in a general population of Okinawa, Japan. Jpn J Med 1998;27:142-9
8 Assy N, Kaita K, Mmin D, Levy C, Rosser B, Minuk G. Fatty infiltration of liver in hyperlipidemic patients. Dig Dis Sci 2000;45:1929-34   DOI   ScienceOn
9 이광은, 김유미, 강은석, 김혜진, 정혜원, 이시훈 등. 비비만인에서 발견되는 비알콜성 지방간의 대사적 의미.대한내과학회지 2002;63(5):488-95
10 Dixon JB, O'Brien PE. Lipid profile in the severely obese: changes with weight loss after lap-band surgery. Obes Res 2002;10(9):903-10   DOI   ScienceOn
11 김형진, 김대중, 김수경, 김세화, 이유미, 안철우 등. 한 국 성인에서 비알콜성 지방간의 중증도에 따른 대사이상의 특징. 대한내분비학회지 2002;17(4):514-24
12 Brunt EM. Alcoholic and nonalcoholic steatohepatitis. Clin Liver Dis 2002;6(2):399-420   DOI
13 Cortez-Pinto H, Camilo ME, Baptista A, De Oliveira AG, De Moura MC. Non-alcoholic fatty liver: another feature of the metabolic syndrome? Clin Nutr 1999;18:353-8   DOI   ScienceOn
14 Okita M, Hayashi M, Sasagawa T, Takagi K, Suzuki K, Kinoyama S, et al. Effect of a moderately energy-restricted diet on obese patients with fatty liver. Nutrition 2001;17:542-7   DOI   ScienceOn
15 Tremblay AJ, Després JP, Piché ME, Nadeau A, Bergeron J, Alméras N, et al. Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome. Metabolism 2004;53(3):310-7   DOI   ScienceOn
16 Day CP, James OF. Steatohepatitis: a tale of two 'hits'? Gastroenterology 1998;114:842-5
17 Lee RG. Nonalcoholic steatohepatitis: a study of 49 patients. Hum Pathol 1989;20:594-8   DOI   ScienceOn
18 윤기석, 백승호, 신은수, 박혜순. 지방간 환자와 관련된 요인. 가정의학회지 1997;18:1426-35
19 송광식, 이기영, 서찬종, 김홍규, 박혜영, 강운호. 비알콜성 지방간과 관련된 인자들에 대한 연구[초록]. 대한당뇨병학회지 2000
20 Contos MJ, Sanyal AJ. The clinicopathologic spectrum and management of nonalcoholic fatty liver disease. Adv Anat Pathol 2002;9:37-51   DOI   ScienceOn
21 Saverymuttu SH, Joseph AE, Maxwell JD. Ultrasound scanning in detection of hepatic fibrosis and steatosis. Br Med J 1986;292:13-5   DOI
22 Falchuk FR, Fiske SC, Haggitt RC, Federman M, Trey C.ㅡPericentral hepatic fibrosis and intracellular hyalin in diabetes mellitus. Gastroenterology 1980;78:535-41
23 Eriksson S, Eriksson KF, Bondesson L. Nonalcoholic steatohepatitis in obesity: a reversible condition. Acta Med Scand 1986;220:83-8
24 Marceau P, Biron S, Hould FS, Marceau S, Simard S, Thung SN, et al. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab 1999;84:1513-7   DOI
25 Morimoto M, Hagbjörk AL, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, et al. Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol 1993;10:459-64   DOI   ScienceOn
26 Bode JC. Nonalcoholic fatty liver disea [letter]. N Engl J Med 2002;347(10):768-9   DOI
27 Foster CJ, Weinsier RL, Birch R, Norris DJ, Bernstein RS, Wang J, et al. Obesity and serum lipids: an evaluation of the relative contribution of body fat and fat distribution to lipid levels. Int J Obes 1987;11(2):151-61
28 Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990;11:74-80   DOI
29 Ludwig J, Viaggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis. Mayo Clinic experience with an hitherto unnamed disease. Mayo Clin Proc 1980;55:434-8
30 Clark JM, Diehl AM, Brancati FL. Nonalcoholic fatty liver disease and the risk of type 2 diabetes in the United States. Diabetes 2001;50 Suppl 2:38-9
31 Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999;107:450-5   DOI   ScienceOn
32 DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991;14:173-94   DOI   ScienceOn
33 김홍규, 서찬종, 윤효중, 황요하, 이기영, 박혜영 등. 비 알콜성 지방간과 대사성 질환들과의 연관성. 대한내분비학회지 2002;17(4):526-33
34 Bjorntorp P. Abdominal obesity and the development of noninsulin-dependent diabetes mellitus. Diabetes Metab Rev 1988;4:615-22   DOI   ScienceOn
35 Schaffner F, Thaler H. Nonalcoholic fatty liver disease. Prog Liver Dis 1986;8:283-98
36 Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors.Hepatology 1990;12:1106-10   DOI
37 Drenick EJ, Simmons F, Murphy JF. Effect on hepatic morphology of treatment of obesity by fasting, reducing diets and small-bowel bypass. N Engl J Med 1970;282:829-34   DOI   ScienceOn
38 김성훈. Genetics of Metabolic Syndrome. 대한비만학회지 2004;13:83-6
39 김용성. 비알콜성 지방간과 대사증후군. 대한내분비학회지 2002;17:460-4
40 Bacon BR, Faragvash MJ, Janny CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an espanded clinical entity. Gastroenterology 1994;107:1103-9   DOI
41 Par\'{e}s A, Tresserras R, Núñez I, Cerralbo M, Palana P, Massip A, et al. Prevalence and risk factors for fatty liver in presumably healthy men. Med Clin (Barc) 2000;114:561-5   DOI   ScienceOn
42 Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285: 2486-97   DOI   ScienceOn