Browse > Article

Mammographic Breast Density and Risk Factors of Breast Cancer in Korean Women Using Multicenter Study  

Cho, Jung-Jin (Departments of Family Medicine, Hallym Sacred Heart Hospital, College of Medicine, Hallym University)
Song, Hong-Ji (Departments of Family Medicine, Hallym Sacred Heart Hospital, College of Medicine, Hallym University)
Koh, En-Young (Departments of Radiology, Hallym Sacred Heart Hospital, College of Medicine, Hallym University)
Song, Yun-Mi (Departments of Family Medicine, Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Han, Bu-Kyung (Departments of Radiology, Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Yun, Young-Sook (Department of Family Medicine, Ilsan Paik Hospital, Inje University)
Park, Hyun-Ah (Departments of Family Medicine, Seoul Paik Hospital, Inje University)
Lee, Sung-Hee (Departments of Family Medicine, Seoul Paik Hospital, Inje University)
Yang, Jeong-Hee (Departments of Family Medicine, College of Medicine, Kangwon National University)
Han, Heon (Departments of Radiology, College of Medicine, Kangwon National University)
Seo, Young-Ran (Department of Radiology, Gangdong Sacred Heart Hospital, College of Medicine, Hallym University)
Publication Information
Korean Journal of Family Medicine / v.27, no.1, 2006 , pp. 33-41 More about this Journal
Abstract
Background: Density patterns on mammography have been related to the risk factors for breast cancer in the western countries. High mammographic density appears to confer a 4-fold risk of breast cancer. While the proportion of high-density mammography is higher in Korean women than in Caucasian women, the incidence of breast cancer in Korean women is considerably lower. Therefore, we examined if the mammographic breast density pattern correlates with the risk factors for breast cancer in Korean women. Methods: In a cross-sectional design, we recruited 1,758 pre- and post-menopause women without prior history of breast cancer and breast surgery who underwent screening mammogram and completed a self-administered questionnaire in 6 general hospitals. On the basis of ACR BI RADS breast composition, four density patterns were classified in caudocranial and mediolateral mammography by a designated radiologist in each hospital. Multiple linear logistic regression was used for statistical analyses. Results: Inter-rater reliability between the initial report and the report made by another blinded radiologist was high (Pearson's co-efficient=0.81). Overall, the age, body mass index, family history of breast cancer, and duration of hormone replacement therapy correlated with the mammographic density patterns. In pre-menopausal women, the high body mass index and parity (=2) were associated with low mammographic density. In post- menopausal women, older age, high body mass index, negative family history of breast cancer, and duration of hormone replacement therapy were associated with low mammographic density. Conclusion: Our data showed that the mammographic breast density patterns correlated with risk factors for breast cancer in Korean women. While the proportion of high-density mammography is higher in Korean women, the incidence of breast cancer is lower than in the western population. This maybe dependent on other unknown factors.
Keywords
mammogram; mammographic density; breast cancer; risk factors;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 유방암. 대한가정의학회편, 한국인의 평생건강관리. 개정판. 서울:계측문화사;2003. p.71-9
2 유근영, 노동영, 이은숙. 유방암의 조기 검진. 대한의사협회지 2002;45(8):992-1004
3 통계청. 2001년 사망원인 통계. 2001
4 Grove JS, Goodman MJ, Gilbert FI Jr, Mi MF. Factors associated with mammographic pattern. Br J Radiol 1985;58:21-5   DOI   ScienceOn
5 Wolfe JN. Breast parenchymal patterns and their changes with age. Radiology 1976;121:545-52   DOI
6 Maskarinec G, Meng L, Ursin G. Ethnic differences in mammographic densities. Int J Epidemiol 2001;30(5):959-65   DOI   ScienceOn
7 Kelsey JL, Gammon MD, John EM. Reproductive factors and breast cancer. Epidemiol Rev 1993;15(1):36-47   DOI
8 de Waard F, Rombach JJ, Collette HJ, Slotboom B. Breast cancer risk associated with reproductive factors and breast parenchymal patterns. J Natl Cancer Inst 1984;72:1277-82
9 Boyd NF, O'Sullivan B, Campbell JE, Fishell E, Sinor I, Cooke G, et al. Mammographic signs as risk factors for breast cancer. Br J Cancer 1982;45:185-93   DOI   ScienceOn
10 Brisson J, Verreault R, Morrison AS, Tennina S, Meyer F. Diet, mammographic features of breast tissue, and breast cancer risk. Am J Epidemiol 1989;130:14-24   DOI
11 Boyd NF, Byng JW, Jong RA, Fishell EK, Little LE, Miller AB, et al. Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study. J Natl Cancer Inst 1995;87:670-5   DOI   ScienceOn
12 Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 1997;350(9084):1047-59   DOI   ScienceOn
13 Porch JV, Lee IM, Cook NR, Rexrode KM, Burin JE. Estrogenprogestin replacement therapy and breast cancer risk: the Women's Health Study (United States). Cancer Causes Control 2002;13(9):847-54   DOI   ScienceOn
14 김승형, 김미혜, 오기근. 유방촬영술상 연령에 따른 한국여성의 유방밀도 분석과 서양여성과의 비교. 대한방사선의학회지 2000;42:1009-14
15 Whitehead J, Carlile T, Kopecky KJ, Thompson DJ, Gilbert FI Jr, Present AJ, et al. The relationship between Wolfe's classification of mammograms, accepted breast cancer risk factors, and the incidence of breast cancer. Am J Epidemiol 1985;122:994-1006   DOI
16 Brisson J, Sadowsky NL, Twaddle JA, Morrison AS, Cole P, et al. Mammographic features of the breast and breast cancer risk. Am J Epidemiol 1982;115:428-37   DOI
17 Brisson J, Morrison AS, Kopans DB, Sadowsky NL, Kalisher L, Twaddle JA, et al. Height and weight, mammographic features of breast tissue, and breast cancer risk. Am J Epidemiol 1984; 119:371-81   DOI
18 Kato I, Beinart C, Bleich A, Su S, Kim M, Toniolo PG. A nested case-control study of mammographic patterns, breast volume, and breast cancer (New York City, NY, United States). Cancer Causes Contol 1995;6:431-8   DOI
19 Dupont WD, Page DL. Menopausal estrogen replacement therapy and breast cancer. Arch Intern Med. 1991;151(1):67-72   DOI
20 Grove JS, Goodman MJ, Gilbert FI, Clyde D. Factors associated with breast structures in breast cancer patients. Cancer 1979;43:1895-9   DOI   ScienceOn
21 Kerlikowske K, Grady D, Barclay J, Sickles EA, Ernster V. Effect of age, breast density, and family history on the sensitivity of first screening mammography. JAMA 1996;276(1): 33-8   DOI
22 Carney PA, Miglioretti DL, Yankaskas BC, Kerlikowske K, Rosenberg R, Rutter CM, et al. Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography. Ann Intern Med 2003;138(3):168-75   DOI   ScienceOn
23 Wolfe JN, Saftlas AF, Salane M. Mammographic parenchymal patterns and quantitative evaluation of mammographic densities: a case-control study. AJR Am J Roentgenol 1987;148: 1087-92   DOI   ScienceOn
24 Stomper PC, D'Souza DJ, DiNitto PA, Arredondo MA, Analysis of parenchymal density on mammograms in 1353 women 25-79 years old. AJR Am J Roentgenol 1996;167(5):1261-5   DOI   ScienceOn
25 Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998;280(7): 605-13   DOI   ScienceOn
26 Maskarinec G, Nagata C, Shimizu H, Kashiki Y. Comparison of mammographic ensities and their determinants in women from Japan and Hawaii. Int J Cancer 2002;102(1):29-33   DOI   ScienceOn
27 Boyd NF, Martin MJ, Stone J, Greenberg C, Minkin S, Yaffe MJ. Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention. Curr Oncol Rep 2001;3(4):314-21   DOI   ScienceOn
28 국립암센터. 2001년 한국중앙암등록 사업 결과. 2001
29 Persson I, Thurfjell E, holmberg L. Effect of estrogen and estrogen-progestin replacement regiemens on mammographic breast parnechimal density. J Clin Oncol 1997;15:3201-7   DOI
30 Saftlas AF, Hoover RN, Brinton LA, Szklo M, Olson DR, Salane M, et al. Mammographic densities and risk of breast cancer. Cancer 1991;67:2833-8   DOI   ScienceOn
31 Byrne C, Schairer C, Wolfe J, Parekh N, Salane M, Brinton LA, et al. Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst 1995;87:1622-9   DOI
32 Boyd NF, Lockwood GA, Byng JW, Tritchler DL, Yaffe MJ. Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev 1998;7(12):1133-44
33 American college of Radiology (ACR) Illustrated Breast Imaging Reporting and Data System (BI-RADSTM). 3rd ed. Reston, Va: American College of Radiology; 1998