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Genotoxicity of Heavy Metals among the Particulates in the Working Environment as Assessed by Tradescantia-Micronucleus (Trad-MCN) Assay  

Shin, Hae-Shik (Korea Atomic Energy Research Institute)
Kim, Jin-Kyu (Korea Atomic Energy Research Institute)
Lee, Jae-Hwan (Dept. of Chemistry, Yonsei University)
Hwang, Kap-Sung (Faculty of Bioengineering, Chung Cheong University)
Kim, Kyun (Korea Institute of Toxicology)
Lee, Jeong-Joo (Dept. of Environmental Health, Yong-In University)
Lee, Jin-Hong (Dept. of Environmental Engineering, Chungnam National University)
Publication Information
Journal of Korean Society for Atmospheric Environment / v.19, no.6, 2003 , pp. 639-646 More about this Journal
Abstract
In this study, we evaluated genotoxicity of heavy metals among particulates with Tradescantia-micronucleus (Trad-MCN) assay in the various working environment. In a synthetic fiber factory and a rubber factory, chromium concentration was higher than any other heavy metals. On the other hand, nickel concentration was the highest in a semi-conductor factory. The difference in genotoxicity among the working environment was statistically significant as Trad-MCN frequencies were 4.07 $\pm$0.35 MCN/100 tetrads (p< 0.01) for the synthetic fiber factory,5.73 $\pm$0.81 MCN/100 tetrads (p< 0.01) for the rubber factory, and 15.60$\pm$2.58 (p< 0.01) (p< 0.001) for the semi -conductor factory. As a result, heavy metals among particulates in the working environment can be considered to have hazardous potential to human health, although they cannot directly induce DNA damage to the workers in the working environments.
Keywords
Working Environment; Heavy metal; ICP analysis; Tradescantia-micronucleus assay;
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