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Immunohistochemical Analysis of TBX3 and $\beta$-catenin in Gastric Cancers  

Song, Jae-Hwi (Department of Pathology, College of Medicine, The Catholic University of Korea)
Yoon, Jung-Hwan (Department of Pathology, College of Medicine, The Catholic University of Korea)
Kang, Young-Hwi (Department of Pathology, College of Medicine, The Catholic University of Korea)
Cao, Zhang (Department of Pathology, College of Medicine, The Catholic University of Korea)
Nam, Suk-Woo (Department of Pathology, College of Medicine, The Catholic University of Korea)
Lee, Jung-Young (Department of Pathology, College of Medicine, The Catholic University of Korea)
Park, Won-Sang (Department of Pathology, College of Medicine, The Catholic University of Korea)
Publication Information
Molecular & Cellular Toxicology / v.5, no.4, 2009 , pp. 328-334 More about this Journal
Abstract
TBX3 has demonstrated oncogenic activity as a downstream target of the Wnt/$\beta$-catenin signaling pathway. In this study, the aim was to determine whether overexpression of the TBX3 protein is involved in the development and/or progression of gastric cancers. We analyzed the expression pattern of the TBX3 and $\beta$-catenin proteins in a series of 186 sporadic gastric cancers. Altered expression of the TBX3 and $\beta$-catenin proteins was observed in 54 (29.0%) and 48 (25.8%) of the 186 gastric cancers. Statistically, overexpression of the TBX3 and $\beta$-catenin proteins was not associated with the clinical and pathological parameters studied including: histological type, tumor location, tumor size, and the 5-year survival (P>0.05). However, TBX3 overexpression was closely associated with lymph node metastasis and aberrant $\beta$-catenin expression (P<0.05). In addition, overexpression of the TBX3 protein was confirmed by Western blot analysis of primary gastric cancer tissues and cell lines. These data suggest that TBX3 overexpression may play a role in the development and progression of sporadic gastric cancers.
Keywords
TBX3; Wnt signaling pathway; Gastric cancer; Expression;
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