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Identification of Atherosclerosis Related Gene Expression Profiles by Treatment of Benzo(a)pyrene in Human Umbilical Vein Endothelial Cells  

Lee, Sun-Hee (Department of Microbiology (BK21) and Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School of Medicine, Kyung Hee University)
Lee, Seung-Eun (Department of Microbiology (BK21) and Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School of Medicine, Kyung Hee University)
Ahn, Hyun-Jong (Department of Microbiology (BK21) and Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School of Medicine, Kyung Hee University)
Park, Cheung-Seog (Department of Microbiology (BK21) and Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School of Medicine, Kyung Hee University)
Cho, Jeong-Je (Department of Microbiology (BK21) and Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School of Medicine, Kyung Hee University)
Park, Yong-Seek (Department of Microbiology (BK21) and Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School of Medicine, Kyung Hee University)
Publication Information
Molecular & Cellular Toxicology / v.5, no.2, 2009 , pp. 113-119 More about this Journal
Abstract
Benzo(a)pyrene (BaP) is a persistent environmental contaminant and is present in tobacco smoke. BaP is considered a major contributor of cardiovascular disease. While the activation of endothelial cells by stimuli including tobacco smoke and air pollution contributes importantly to cardiovascular disease, the nature of BaP's mechanism is unclear. In this study, gene expression profiles were investigated in BaPtreated human umbilical vein endothelial cells (HUVECs). Various atherosclerosis related genes could be up- and down-regulated more than 2-fold by BaP, and mRNA levels of atherosclerosis related genes encoding apolipoproteinC III, TLR 2, ICAM 1 and exportin 4 were significantly increased by BaP. Our data suggest that BaP-mediated changes in gene expression contribute to the progression of cardiovascular disease.
Keywords
Benzo(a)pyrene; Cardiovascular disease; Endothelial cells; Gene expression;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 8  (Related Records In Web of Science)
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