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The Effect of Exposure to Mixed Organic Solvents on Lipid Peroxidation in Ship Building Painters  

Park, Jun-Ho (Department of Preventive Medicine, Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine)
Cha, Bong-Suk (Department of Preventive Medicine, Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine)
Chang, Sei-Jin (Department of Preventive Medicine, Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine)
Koh, Sang-Baek (Department of Preventive Medicine, Institute of Life Long Health, Yonsei University Wonju College of Medicine)
Eom, Ae-Yong (Department of Nursing, Margaret Prtchard University)
Lee, Kang-Myeung (Department of Preventive Medicine, Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine)
Jung, Min-Ye (Department of Occupational Therapy, College of Health Science, Yonsei University)
Choi, Hong-Soon (Institute of Occupational and Environmental Health, Kwandong University)
Publication Information
Molecular & Cellular Toxicology / v.4, no.4, 2008 , pp. 360-365 More about this Journal
Abstract
In the last several years, studies on the association of oxidative stress damage with exposure in the work place have been conducted. Xenobiotics create an imbalance of the homeostasis between oxidant molecules and antioxidant defense. By monitoring oxidative stress biomarkers, information was obtained on damages induced by oxidative stress and the toxicity of xenobiotics. In the present study, a Job Exposure Matrix (JEM) was constructed using the data from the Working Environment Measurement (WEM) of painters in the shipyard industry from the past 3 years to assess the exposure status. Additionally, by measuring the concentration of urinary malondialdehyde (MDA), the effect of lipid peroxidation was examined. The subjects consisted of 68 workers who were exposed to mixed organic solvents in the painting process and 25 non-exposure controls. The exposure indices of the exposure groups were significantly different (sprayer: 0.83, touchup: 0.54, assistant: 0.13, P<0.05). The urinary MDA concentration of the exposure group was 48.60${\pm}$ 39.23 ${\mu}mol$/mol creatinine, which was significantly higher than 18.03${\pm}$16.33 ${\mu}mol$/mol creatinine of the control group (P<0.05). From the multiple regression analysis of urinary MDA, the regression coefficient for exposure grade was statistically significant. In future studies, evaluation of the antioxidant levels of subjects should be performed simultaneously with quantitative exposure measurements.
Keywords
Mixed organic solvents; Malondialdehyde; Job exposure matrix; Painting workers;
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