Browse > Article

Photoprotective Effects of Minerals from Korean Indigenous Ores on UVA-irradiated Human Dermal Fibroblast  

Kang, Dong-Kyu (Department of Medical Biotechnology, SoonChunHyang University)
Lee, Mi-Young (Department of Medical Biotechnology, SoonChunHyang University)
Publication Information
Molecular & Cellular Toxicology / v.4, no.2, 2008 , pp. 150-156 More about this Journal
Abstract
The photoprotective effects of minerals from Korean indigenous ores, consisting mainly of sericite, on UVA-irradiated human dermal fibroblast (HDF) were examined. Zymographic analysis showed that the treatment of the minerals significantly reduced the UVA-enhanced MMP-1 activity and mRNA level. The minerals also showed strong inhibitory effect on MMP-2 activity and mRNA expression. Moreover, the minerals were better than polyphenol in reducing MMP-1 and MMP-2 expressions. Notably, the minerals significantly enhanced collagen biosynthesis in the HDF. Inhibition of the elastase activity and protection against the oxidatively damaged HDF cell were also found in the presence of the minerals. Taken together, the ore minerals may be used as the potent photo-protective and anti-skin-aging ingredients which can prevent skin cell damage by UVA.
Keywords
Ore minerals; Human dermal fibroblast; Photo-protection;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
연도 인용수 순위
1 Isabel Carretero, M. Clay minerals and their beneficial effects upon human health. Appl Clay Sci 21:155-163 (2002)   DOI   ScienceOn
2 Celso de Sousa, F. G. & Joao Baptista, P. S. Minerals and clay minerals in medical geology. Applied Clay Sci 36:4-21 (2007)   DOI   ScienceOn
3 Levene, C. I. & Bates, C. J. Ascorbic acid and collagen synthesis in cultured fibroblasts. Ann N Y Acad Sci 258:288-306 (1975)   DOI
4 Taddese, S., Weiss, A. S., Neubert, R. H. & Schmelzer, C. E. Mapping of macrophage elastase cleavage sites in insoluble human skin elastin. Matrix Biol (2008)
5 Birkedal-Hansen, H. et al. Matrix metalloproteinases: A review. Crit Rev Oral Biol and Med 4:197-250 (1993)   DOI
6 Li, Y. L. et al. Regulatory role of extracellular matrix components in expression of matrix metalloproteinases in cultured hepatic stellate cells. Cell Str Func 24:255-261 (1999)   DOI   ScienceOn
7 Seo, J. Y., Cho, K. H., Eun, H. C. & Jung, J. H. Skin aging from phenotype to mechanism. Kor J Invest Dermatol 8:187-194 (2001)
8 Viseras, C., Aguzzi, C., Cerezo, P. & Lopez-Galindo, A. Uses of clay minerals in semisolid health care and therapeutic products. Applied Clay Sci 36:37-50 (2007)   DOI   ScienceOn
9 Breul, S. D. et al. Control of collagen production by human diploid lung fibroblasts. J Biol Chem 255: 5250-5260 (1980)
10 Goetz, M. E. & Luch, A. Reactive species: A cell damaging rout assisting to chemical carcinogens. Cancer Lett (2008)
11 Hong, M. H. Mineral oriental drugs in Korea(I). Kor J Pharmacol 6:5-74 (1975)
12 Greul, A. K. et al. Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol Appl Skin Physiol 15:307-315 (2002)   DOI
13 Kim, Y. J., Song, M. & Ryu, J. C. Identification of differentially expressed genes (DEGs) by malachite green in HepG2 Cells. Mol Cell Toxicol 4:22-30 (2008)   과학기술학회마을
14 Conley, S. M., Bruhn, R. L., Morgan, P. V. & Stamer, W. D. Selenium's effects on MMP-2 and TIMP- 1 secretion by human trabecula meshwork cells. Invest Ophthalmol Vis Sci 45:473-479 (2004)   DOI   ScienceOn
15 Barbara, A. & Glichrest, M. D. Skin aging and photoaging: An overview. J Am Acad Dermatol 21:610-613 (1989)   DOI   ScienceOn
16 Pinnell, S. R., Murad, S. & Darr, D. Induction of collagen synthesis by ascorbic acid. Arch Dermatol 123:1684-1686 (1987)   DOI
17 Nishikawa, M. Reactive oxygen species in tumor metastasis. Cancer Lett (2008)
18 Hance, A. J. & Crystal, R. G. Rigid control of synthesis of collagen types I and III by cells in culture. Nature 268:152-154 (1977)   DOI   ScienceOn
19 Kivirikko, K. I. & Prockop, D. J. Enzymatic hydroxylation of proline and lysine in protocollagen. Proc Natl Acad Sci U S A 57:782-789 (1962)
20 Williams, S. N. et al. Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. Chem Biol Inter 128:211-229 (2000)   DOI   ScienceOn
21 Tokubo, K. Sericite and muscovite. Fragrance J 80:60 (1998)
22 Lee, J. Y. et al. A geological and oriental medical study on Talc in 'Donguebogam'. J Sci Edu 23:101-114 (1999)
23 Clerkin, J. S., Naughton, R., Quiney, C. & Cotter, T. G. Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett (2008)
24 Robinson, P. Woodlands clay-sericite mica in a claylike state. Appl Clay Sci 2:14-20 (1984)
25 Katiyar, S. K., Afaq, F., Perex, A. & Mukhtar, H. Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation induced oxidative stress. Carcinogenesis 22:287-294 (2001)   DOI   ScienceOn
26 Hoffmann, P. R. & Berry, M. J. The influence of selenium on immune responses. Mol Nutr Food Res (2008)
27 Lee, S. M. et al. The Anti-inflammatory effect of IH- 901 in HT-29 Cells. Mol Cell Toxicol 3:254-261 (2007)   과학기술학회마을
28 Miyachi, Y. Photoaging from an oxidative standpoint. J Dermatol Sci 9:79-86 (1995)   DOI   ScienceOn
29 Bunnell, J. E. Medical geology: an emerging discipline on the ecosystem human health interface. Ecohealth 1:15-18 (2004)   DOI
30 Selinus, O. Medical geology: an emerging speciality. Terrae 1:A1-A8 (2004)
31 Geesin, J. C. et al. Ascorbic acid specifically increases type I and III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 90:420-424 (1988)   DOI   ScienceOn
32 Rosenbloom, J., Harsch, M. & Jimenez, S. Hydroxyproline content determines the denaturation temperature of chick tendon collagen. Arch Biochem Biophys 158:478-484 (1973)   DOI   ScienceOn
33 Kim, Y. H. et al. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient. Biosci Biotechnol Biochem 72:303-311 (2008)   DOI   ScienceOn
34 Bornstein, P. & Sage, H. Structually distinct collagen types. Annu Rev Biochem 49:957-1003 (1980)   DOI   ScienceOn