Efficient Gene Delivery through the Human Transferrin Receptor of Fibroblast-like Synoviocytes Stimulated with bFGF: a Potential Target Receptor for Gene Transduction in Rheumatoid Arthritis
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Kim, Hak-Jae
(Kohwang Medical Research Institute, Kyung Hee University)
Joung, In-Sil (Department of Biological Science, Hanseo University) Nah, Seong-Su (Kohwang Medical Research Institute, Kyung Hee University) Lee, Kyu-Hoon (Department of Physical Medicine and Rehabilitation, College of Medicine, Hanyang University) KimKwon, Yun-Hee (Department of Biology and Department of Life and Nanopharmaceutical Science, Kyung Hee University) Chung, Joo-Ho (Kohwang Medical Research Institute, Kyung Hee University) Hong, Seung-Jae (Kohwang Medical Research Institute, Kyung Hee University) |
1 | Sweeney, S. E. & Firestein, G. S. Rheumatoid arthritis: regulation of synovial inflammation. Int. J. Biochem. Cell Biol. 36(3):372-378 (2004) DOI ScienceOn |
2 | Telfer, J. F. & Brock, J. H. Expression of ferritin, transferrin receptor, and non-specific resistance associated macrophage proteins 1 and 2 (Nramp1 and Nramp2) in the human rheumatoid synovium. Ann. Rheum. Dis. 61(8):741-744 (2002) DOI ScienceOn |
3 | Toh, M. L. et al. Enhancement of Adenovirus-Mediated Gene Delivery to Rheumatoid Arthritis Synoviocytes and Synovium by Fiber Modifications: Role of Arginine-Glycine-Aspartic Acid (RGD)-and Non- RGD-Binding Integrins. J. Immunol. 175(11):687- 698 (2005) |
4 | Toh, M. L. Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen- activated protein kinases, in rheumatoid arthritis: upregulation by interleukin-1 and glucocorticoids. Arthritis Rheum. 50(10):3118-3128 (2004) DOI ScienceOn |
5 | Keystone, E. C. Strategies to control disease in rheumatoid arthritis with tumor necrosis factor antagonists-an opportunity to improve outcomes. Nat. Clin. Pract. Rheumatol. 2(11):594-601 (2006) DOI ScienceOn |
6 | Winthrop, K. L. Risk and prevention of tuberculosis and other serious opportunistic infections associated with the inhibition of tumor necrosis factor. Nat. Clin. Pract. Rheumatol. 2(11):602-610 (2006) DOI ScienceOn |
7 | Arnett, F. C. et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31(3):315-324 (1988) DOI ScienceOn |
8 | Chabaud, M., Fossiez, F., Taupin, J. L. & Miossec, P. Enhancing effect of IL-17 on IL-1 induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. J. Immunol. 161(1):409-414 (1998) |
9 | Joung, I. et al. Improved gene delivery into neuroglial cells using a fiber-modified adenovirus vector. Biochem. Biophys. Res. Commun. 328(4):1182-1187 (2005) DOI ScienceOn |
10 | Manabe, N. et al. Involvement of fibroblast growth factor-2 in joint destruction of rheumatoid arthritis patients. Rheumatology 38(8):714-720 (1999) DOI |
11 | Schmidt, M. R., Piekos, B., Cabatingan, M. S. & Woodland, R. T. Expression of a human Coxsackieadenovirus receptor transgene permits adenovirus infection of primary lymphocytes. J. Immunol. 165(7): 4112-4119 (2000) DOI |
12 | Bakker, A.C. et al. A tropism-modified adenoviral vector increased the effectiveness of gene therapy for arthritis. Gene. Ther. 8(23):1785-1793 (2001) DOI |
13 | Doan, Q. V., Chiou, C. F. & Dubois, R. W. Review of eight pharmacoeconomic studies of the value of biologic DMARDs (adalimumab, etanercept, and infliximab) in the management of rheumatoid arthritis. J. Manag. Care. Pharm. 12(7):555-569 (2006) DOI |
14 | Thomas, P., Ulf, M. L., Renate, E. G. & Steffen, G. Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res. Ther. 2(5):361-367 (2000) DOI ScienceOn |
15 | Genovese, M. C. Biologic therapies in clinical development for the treatment of rheumatoid arthritis. J. Clin. Rheumatol. 11(3 Suppl):S45-54 (2005) DOI |
16 | Goossens, P. H. et al. Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber. Arthritis Rheum. 44(3):570-577 (2001) DOI ScienceOn |
17 | Yeh, P. & Perricaudet, M. Advances in adenoviral vectors: from genetic engineering to their biology. FASEB J. 11(8):615-623 (1997) DOI |
18 | Sutherland, R. et al. Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. PNAS. 78(7):4515-4519 (1981) DOI |
19 | Wilder, R. L. et al. Endothelial cells and the pathogenesis of rheumatoid arthritis in humans and streptococcal cell wall arthritis in Lewis rats. J. Cell. Biochem. 45(2):162-166 (1991) DOI |
20 | Mohr, W., Beneke, G. & Mohing, W. Proliferation of synovial lining cells and fibroblasts. Ann. Rheum. Dis. 34(3):219-224 (1975) DOI ScienceOn |
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