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Biological Effects of Smoking-induced Environmental Toxicity  

Sohn, Sung-Hwa (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Kim, In-Kyoung (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Kim, Ki-Nam (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Kim, Hye-Won (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Seo, Sang-Hui (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Lee, Seung-Ho (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Kim, Yu-Ri (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Lee, Eun-Il (Department of Preventive, College of Medicine, Korea University)
Kim, Meyoung-Kon (Department of Biochemistry & Molecular Biology, College of Medicine, Korea University)
Publication Information
Molecular & Cellular Toxicology / v.2, no.3, 2006 , pp. 202-211 More about this Journal
Abstract
Our objective is to identify molecular factors which contribute to the increased risk of smoke in human. About 677 workers who had control and experimental groups according to their urinary Naphthol levels were enrolled in our study. In the present study, we investigated the effects of smoking on gene expression profiles in human. We determined differential gene expression patterns in smoker versus non-smoker using cDNA microarray. Specific genes were up-or down-regulated according to smoking and age. Inflammatory related genes such as cytokine, interleukin, and tumor necrosis factor were up-regulated, DNA repair related genes such as high-mobility group (nonhistone chromosomal) protein 1, and protein 2 were down-regulated, apoptosis related genes such as myeloperoxidase and Bcl-2-associated athanogene were down-regulated, and cell cycle related genes were down-regulated. In our epidemiological study, notably, inflammatory, DNA repair, apoptosis, signal transduction, metabolism, cell cycle, cell proliferation, transcription related genes were regulated.
Keywords
Smoking; Urinary Naphthol; Gene expression profiling; cDNA microarray;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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