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Linkage Disequilibrium (LD) Mapping and Tagging SNP Selection of C-Fos Induced Growth Factor (Figf) Gene in Korean Population  

Kim, Sook (DNA Link, Inc.)
Yoo, Yeon-Kyung (DNA Link, Inc.)
Jang, Hye-Yoon (DNA Link, Inc.)
Shin, Eun-Soon (DNA Link, Inc.)
Cho, Eun-Young (DNA Link, Inc.)
Kim, Eu-Gene (Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
NamKung, Jung-Hyun (Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Yang, Jun-Mo (Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Lee, Jong-Eun (DNA Link, Inc.)
Publication Information
Molecular & Cellular Toxicology / v.2, no.1, 2006 , pp. 7-10 More about this Journal
Abstract
We performed comprehensive SNP validation and linkage disequilibrium (LD) analysis of the c-fos induced growth factor (Figf) gene in Korean population. Out of 32 SNPs, only 9 SNPs were polymorphic in Korean population. Validated SNPs formed a single extended haplotype block with strong LD through the entire length of the gene. Tagging SNP analysis picked only 2 SNPs to represent most of the genetic variation information of the Figf gene. Our results demonstrate the utility of LD block and tagging SNP analysis for an efficient way of performing a candidate gene based association study.
Keywords
SNP; FigF gene; Haplotype; Linkage disequilibrium;
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Times Cited By Web Of Science : 9  (Related Records In Web of Science)
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