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Identification of Potential Carcinogenic Biomarker Following Exposure to N-ethyl-N-nitrosourea in Mice  

Lim, Jung-Sun (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Jeong, Sung-Young (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Hwang, Ji-Yoon (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Cho, Kyu-Hyuk (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Cho, Jae-Woo (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Han, Sang-Seop (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Song, Chang-Woo (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Yoon, Seok-Joo (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
Publication Information
Molecular & Cellular Toxicology / v.1, no.2, 2005 , pp. 106-110 More about this Journal
Abstract
N-ethyl-N-nitrosourea (ENU), which is a toxin and a carcinogen, as well as a mutagen, has a variety of effects on mice. ENU induces point mutation in male germ cell. Number of mutant animals are developed with ENU treatment. However, potentiality ot ENU as a carcinogen is not fully understood, even though, mutagenicity of ENU is broadly studied, In the present study, the gene expression profiling and histopathological investigation of ENU treated mouse's liver and brain were investigated. Also, the expression patterns of cancer related genes in ENU-treated mouse were analyzed.
Keywords
ENU; carcinogen; gene expression; biomarker;
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1 Loveless, A. & Hampton, C.L. Inactivation and mutation of coliphage $T_{2}$ by N-methyl-N- and N-ethyl-Nnitrosourea. Mutation Res. 7, 1-12(1969)   DOI   ScienceOn
2 Baumann, G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr. Rev. 12, 424-449 (1991)   DOI   PUBMED   ScienceOn
3 Vousden, K.H. & Lu, X. Live or let die: the cell's response to p53, Nat. Rev. Cancer 2, 594-604 (2002)   DOI   ScienceOn
4 Mitsumori, K. et al. Rapid induction of uterine tumors with p53 point mutation in heterozygous p53-deficient CBA mice given a single intraperitoneal administration of N-ethyl-N-nitrosourea, Carcinogenesis 21(5), 1039-1042(2000)   DOI   ScienceOn
5 Silvestro, D. & Carlson, G.P. Inflammation an inducer of metallothionein inhibits carbon tetrachlorideinduced hepatotoxicity in rats. Toxicol. lett. 60, 175- 181 (1992)   DOI   ScienceOn
6 Ulrich, R. & Friend, S.H. Toxicogenomics and drug discovery: Will new technologies help us produce better drugs? Nature Reviews, 1, 84-88 (2002)   DOI   ScienceOn
7 Magee, P.N. & Barnes, J.M. Carcinogenic nitroso compounds. Adv. Cancer Res. 10, 164-246 (1967)
8 Bertucci, F. et al. Gene expression profiling of primary breast carcinomas using arrays of candidate genes. Hum. Mol. Genet. 9, 2981-2991 (2000)   DOI   ScienceOn
9 Costoya, J.A. et al. Expression of the human growth hormone normal gene (hGH-N) in proliferating and differentiated HL-60 cells. Exp. Cell. Res. 228, 164- 167 (1996)   DOI   ScienceOn
10 Mitsiades, N. et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc. Natl. Acad. Sci. U.S.A. 99, 14374-14379 (2002)   DOI   ScienceOn
11 Kelly, S.L. et al. Over expression of metallothionein confers resistance to anti-cancer drugs. Science 241, 1813-1815 (1988)   DOI   PUBMED
12 Kagi, J.H.R. Overview of metallothionein. Metallobiochemistry Part B: metallothionein and related molecules. Methods Enzymol. 205, 613-626 (1993)
13 Murota, T. & Shibuya, T. Genetics analysis of mutants in mice induced by N-ethyl-N-nitrosourea. Jpn. J. Genet. 58, 263-267 (1983)   DOI
14 Joseph, M.G. et al. Metallothionein expression in patients with small cell carcinoma of the lung. Correlation with other molecular markers and clinical out come. Cancer 92, 836-842(2001)   DOI   PUBMED   ScienceOn
15 Levine, A.J. p53, the cellular gatekeeper for growth and division, Cell 88, 323-331 (1997)   DOI   PUBMED   ScienceOn
16 Pennie, W.D., Tugwood, J.D., Oliver, G.J.A. & Kimber, I. The principles and practice of toxicogenomics: Applications and opportunities. Toxicol. Sci. 54, 277-283 (2000)   DOI   ScienceOn
17 Fraser, R.A., Attardo, D. & Harvey, S. Growth hormone receptors in hypothalamic and extra hypothalamic tissues. J. Mol. Endocrinol. 5, 231-238 (1990)   DOI   ScienceOn
18 Devilard, E. et al. Gene expression profiling defines molecular subtypes of classical Hodgkin's disease. Oncogene 21, 3095-3102 (2002)   DOI   ScienceOn
19 Magee, P.N. & Barnes, J.M. Carcinogenic nitroso compounds. Adv. Cancer Res. 10, 164-246 (1967)
20 Cherian, M.G. et al. National cancer institute workshop on possible roles of metallothionein in carcinogenesis. Cancer Res. 53, 922-925 (1993)
21 Russel, W.L. et al. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc. Natl. Acad. Sci. USA. 76, 5818-5819 (1979)   DOI   ScienceOn