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http://dx.doi.org/10.5051/jpis.2001080054

Evaluation of the mechanical properties and clinical efficacy of biphasic calcium phosphate-added collagen membrane in ridge preservation  

Lee, Jung-Tae (Department of Periodontics, One-Stop Specialty Center, Seoul National University Dental Hospital)
Lee, Yoonsub (Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry)
Lee, Dajung (Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry)
Choi, Yusang (Department of Bio Team, Implant Research Institute, Dentis Co., Ltd.)
Park, Jinyoung (Department of Bio Team, Implant Research Institute, Dentis Co., Ltd.)
Kim, Sungtae (Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry)
Publication Information
Journal of Periodontal and Implant Science / v.50, no.4, 2020 , pp. 238-250 More about this Journal
Abstract
Purpose: This study aimed to evaluate the biocompatibility and the mechanical properties of ultraviolet (UV) cross-linked and biphasic calcium phosphate (BCP)-added collagen membranes and to compare the clinical results of ridge preservation to those obtained using chemically cross-linked collagen membranes. Methods: The study comprised an in vitro test and a clinical trial for membrane evaluation. BCP-added collagen membranes with UV cross-linking were prepared. In the in vitro test, scanning electron microscopy, a collagenase assay, and a tensile strength test were performed. The clinical trial involved 14 patients undergoing a ridge preservation procedure. All participants were randomly divided into the test group, which received UV cross-linked membranes (n=7), and the control group, which received chemically cross-linked membranes (n=7). BCP bone substitutes were used for both the test group and the control group. Cone-beam computed tomography (CBCT) scans were performed and alginate impressions were taken 1 week and 3 months after surgery. The casts were scanned via an optical scanner to measure the volumetric changes. The results were analyzed using the nonparametric Mann-Whitney U test. Results: The fastest degradation rate was found in the collagen membranes without the addition of BCP. The highest enzyme resistance and the highest tensile strength were found when the collagen-to-BCP ratio was 1:1. There was no significant difference in dimensional changes in the 3-dimensional modeling or CBCT scans between the test and control groups in the clinical trial (P>0.05). Conclusions: The addition of BCP and UV cross-linking improved the biocompatibility and the mechanical strength of the membranes. Within the limits of the clinical trial, the sites grafted using BCP in combination with UV cross-linked and BCP-added collagen membranes (test group) did not show any statistically significant difference in terms of dimensional change compared with the control group.
Keywords
Alveolar bone loss; Artificial membranes; Biocompatible materials; Periodontal atrophy; Ultraviolet rays;
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Times Cited By KSCI : 4  (Citation Analysis)
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