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Experimental study on the periodontal regenerative capacity of moldable synthetic peptide domain gel in degree III furcation defect of beagles  

Kim, Jeong-Beom (Department of Periodontology, School of Dentistry, Seoul National University)
Park, Yoon-Jeong (Department of Head and Neck Reconstruction, School of Dentistry, Seoul National University)
Lee, Sang-Cheol (NIBEC Corp.)
Kim, Tae-Il (Department of Periodontology, School of Dentistry, Seoul National University)
Seol, Yang-Jo (Department of Periodontology, School of Dentistry, Seoul National University)
Lee, Yong-Moo (Department of Periodontology, School of Dentistry, Seoul National University)
Gu, Young (Department of Periodontology, School of Dentistry, Seoul National University)
Rhyu, In-Chul (Department of Periodontology, School of Dentistry, Seoul National University)
Han, Soo-Boo (Department of Periodontology, School of Dentistry, Seoul National University)
Chung, Chong-Pyoung (Department of Periodontology, School of Dentistry, Seoul National University)
Publication Information
Journal of Periodontal and Implant Science / v.38, no.4, 2008 , pp. 621-628 More about this Journal
Abstract
Purpose: Osteopontin is one of the major non-collagenous protein of hard tissue. Use of peptide domain of biologically active protein has some advantages. The objective of this experimental study is evaluation of periodontal regenerative potency of synthetic peptide gel which containing collagen binding domain of osteopontin in the degree III periodontal defect of beagle dogs. Material and Methods: Experimental degree III furcation defect was made in the mandibular third and fourth premolar of beagles. Regenerative material was applied during flap operation. 8 weeks after regenerative surgery, all animals were sacrificed and histomorphometric measurement was performed to calculate the linear percentage of the new cementum formation and the volume percentage of new bone formation. Result: The linear percent of new cementum formation was 41.6% at control group and 67.1% at test group and there was statistically significant difference. The volume percent of new bone formation was 52.1% at control group and 58.9% at test group. Conclusion: As the results of present experiment, synthetic peptide gel containing collagen binding domain of osteopontin significantly increase new bone and cementum formation in the degree III furcation defect of canine mandible.
Keywords
Collagen binding domain; Peptide domain; Regeneration; Osteopontin;
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