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The effects of polylactic/polyglycolic copolymer (PLA/PGA) membrane on the healing of 1-wall intrabony defects in beagle dogs  

Kim, Sung-Koo (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University)
Hwang, Sung-Joon (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University)
Kim, Min-Kyoung (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University)
Kim, Chang-Sung (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University)
Lee, Doug-Youn (Brain Korea 21 Project for Medical Science, Department and Research Institute of Dental Biomaterials and Bioengineering, College of Denistry, Yonsei University)
Lee, Yong-Keun (Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University)
Cho, Kyoo-Sung (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Brain Korea 21 Project for Medical Science)
Chai, Jung-Kiu (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University)
Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Brain Korea 21 Project for Medical Science)
Choi, Seong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Brain Korea 21 Project for Medical Science)
Publication Information
Journal of Periodontal and Implant Science / v.33, no.4, 2003 , pp. 599-613 More about this Journal
Abstract
The goal of periodontal treatment is regeneration of the periodontium. Bone graft and absorbable PLA/PGA membrane have been used for this purpose. In this study, 4${\times}$4mm 1-wall intrabony defects were surgically created bilaterally in the mandible of five male beagles. The control group went through a conventional flap operation, while the experimental group I was treated with absorbable PLA/PGA membranes only, group II was treated with absorbable membrane and calcium phosphate. The results are the following : 1. The defect height was 4.82${\pm}$0.45mm in the control group, 4.93${\pm}$0.79mm in the experimental I group, and 4.92${\pm}$0.62mm in the experimental II group. There was no statistically significant difference among 3 groups(P <0.05). 2. The amount of junctional epithelium migration was 30.90${\pm}$9.92% of the defect height in the control group, 39.16${\pm}$7.51% in the experimental I group, and 38.68${\pm}$12.22% in the experimental II group. There was no statistically significant difference among 3 groups(P <0.05). 3. The amount of connective tissue adhesion was 36.38${\pm}$9.03% in the control group, 14.73${\pm}$3.93% in experimental I group, and 27.87${\pm}$9.70% experimental II group. Experimental group I was a statistically significantly different from control group(P <0.05). 4. The amount of new cementum regeneration was 32.92${\pm}$10.51%, 50.04${\pm}$7.61%, and 39.62${\pm}$12.14% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05). 5. The amount of new alveolar bone regeneration was 27.24${\pm}$7.49%, 40.75${\pm}$8.03%, and 36.47${\pm}$15.11% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P <0.05). The results suggest that the use of PLA/PGA membrane in 1-wall intrabony defect of beagle dogs may promote periodontal regeneration. Further studies are required to determine their regeneration effects.
Keywords
PLA/PGA membrane; calcium phosphate; 1-wall defects; periodontal regeneration;
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