Browse > Article

THE EFFECTS OF PASTE TYPE CALCIUM SULFATE ON THE PERIODONTAL HEALING OF 3-WALL INTRABONY DEFECTS IN DOGS  

Hyun, Suk-Ju (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal regeneration)
Kim, Chang-Sung (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal regeneration)
Choi, Seong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal regeneration)
Cho, Kyoo-Sung (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal regeneration)
Chai, Jung-Kiu (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal regeneration)
Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal regeneration)
Publication Information
Journal of Periodontal and Implant Science / v.32, no.2, 2002 , pp. 429-455 More about this Journal
Abstract
There are numerous kind of materials and techniques to regenerate the periodontal tissue which has been lost due to destructive periodontal disease, including bone graft material. Many bone graft materials have been reported and among these materials, synthetic material has been developed fin the long time because of its sufficient supply economically. Calcium sulfate which was evaluated as including much calcium, has been used in the clinical field. In the dental field calcium sulfate has been used as bone graft material and Kim reported that improved bone formation and more amount of new attachment after grafting calcium sulfate. but, because calcium sulfate has the problem that it generates the heat in setting period and resolves fast, we need to evaluate the effect of the improved calcium sulfate on periodontal tissue. The present study evaluates the effect of paste type calcium sulfate on the epithelial migration, alveolar bone regeneration, cementum formation and gingival connective tissue attachment in intrabony defect in dogs. Four millimeter deep and four millimeter wide 3-wall defects were surgically created in the mesial or distal aspects of premolars or molars. the test group received paste-type calcium sulfate with a flap procedure and the control group underwent flap procedure only. Histologic analysis after 8 weeks of healing revealed the following results : 1. The length of epithelial growth(the distance from CEJ to the apical end of JE) was 0.52${\pm}$0.26mm in the control and 0.56${\pm}$0.25mm in the test group. there was no statistically significant difference between the two groups. 2. The length of connective tissue adhesion was 1.74${\pm}$1.06mm in the control and 1.28${\pm}$0.57mm in the test group. there was no statistically significant difference between the two groups. 3. The length of new bone was 2.01${\pm}$0.95mm in the control and 2.62${\pm}$0.81mm in the test group. there was no statistically significant difference between the two groups. 4. The length of new cementum was 1.86${\pm}$0.80mm in the control and 2.77${\pm}$ 0.86mm in the test group. there was a statistically significant difference between the two groups.(P<0.01) These results suggest that the use of paste type calcium sulfate in 3-wall intrabony defects has significant effect on new cementum formation , but doesn't have any significant effect on the prevention of junctional epithelium migration and new bone formation. Finally, the paste type calcium sulfate that is used in this study is suggested to be the material that can have a significant effect on the periodontal healing, if its biocompatibility is improved.
Keywords
periodontal regeneration; calcium sulfate; bone graft;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Gottlow, J. et al : New attachment formation in the human periodontium by guided tissue regeneration, J. Clin. Periodont., 13: 604, 1986   DOI
2 Pontoriero, R., Nyman, S., Lindhe, J., Rosenberg, E., Sanavi, F. : Guided tissue regeneration in degree II furcation-involved mandibular molars, J. Clin. Periodont., 15: 247, 1988   DOI
3 Becker, W., Becker, B.E., Caffesse, R.: A comparison of deminealized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets, J. Periodont., 65: 1128-1133, 1994   DOI
4 Peltier, L.F. : The use of plaster of Paris to fill defects in bone, Ann. Surg., 146: 61, 1957
5 Wikesjo, UME., Nilveus R. Periodontal repair in dogs: Effect of wound stabilization on healing, J. Periodont., 61: 719-724, 1990   DOI
6 Wikesjo UME., Nilveus RE, Selvig KA. : Significance of early healing events on periodontal repair, A review. J. Periodont., 63: 158-165, 1992   DOI
7 Barnett J.D., Mellonig J.T., Gray J.L., Towle H.J.: Comparison of freeze-dried bone allograft and porous hydroxyapatite in human periodontal defects, J. Periodont., 60: 231-237, 1989   DOI
8 Habal M.B., Reddi A.H.: Bone grafts & bone sustitutes. Philadelphia: W.B. Saunders Co., 1992
9 Mellonig, J.T.: Bone allografts in periodontal therapy, Clin. Orthop., 324:116-125, 1996   DOI
10 Steiner, S.R., Crigger, M., Egelberg, J.: Connective tissue regeneration to periodontally diseased teeth. II. Histologic observations of cases replaced flap surgery, J. Periodont. Res., 16: 109, 1981   DOI
11 김현영, 채중규 : 성견의 3면 골내낭에서 calcium sulfate를 탈회냉동건조골과혼합이식 및 차단막으로 사용할 시의 치주조직의 치유효과, 연세 치대 논문집 Vol. 10, 1995
12 최미령, 조규성, 채중규, 김종관 : 성견의 3면 골내낭에 calcium carbonate와 calcium sulfate의 혼합이식이 치주조직 치유에 미치는 영향, 대한치주과학회지 24; 633, 1994
13 Libin, B.M., Ward, H.L., Fishman, L.: Decalcified, lypophilized bone allografts for use in human periodontal defects, J. Periodont., 46: 51, 1975   DOI
14 Wikesjo, UME., Nilveus R. : Periodontal repair in dogs : Healing patterns in large circumferential periodontal defects, J. Clin. Periodont., 18: 49-591, 1991   DOI
15 Urist, M.R.,. Strates, B.S.: Bone morphogenic protein, J. Dent. Res., 50: 1392, 1971   DOI
16 Selvig, K.A., Kersten, B.G. and Wikesjo, U.M.E. : Surgical treatment of intrabony periodontal defects using expanded polytetrafluoroethylene barrier membranes : Influence of defect configuration on healing response, J. Periodont., 64: 730, 1993   DOI
17 Becker, W., Urist, M.R., Tucker, L.M., Becker, B.E., Ochsenbein, C.: Human demineralized freeze-dried bone.: Inadequate induced bone formation in athymic mice, A preliminary study. J. Periodont., 66: 822-828, 1995   DOI
18 Karing, T., Nyman, S., Gottlow, J., Laurell, L: Development of the biological concept of guided tissue regeneration-animal and human studies, Periodontol 2000, 1: 26-35, 1993   DOI   ScienceOn
19 Peltier, L.F., Orn, D. : The effect of the addition of plaster of Paris to autogenous and homogenous bone grafts in dogs, Surg. Forum. 8: 571, 1958
20 Urist, M.R.: Bone formation by osteoinduction, Science, 150: 893, 1965   DOI   ScienceOn
21 Wikesjo, UME., Periodontal repair in dogs : Connective tissue repair in supraalveolar periodontal defects, [Thesis].Malmo, Sweden: Lund University, 1991.
22 Radentz, W.H., Collings, C.K. : The implantation of plaster of Paris in the alveolar process of the dog, J. Periodont., 36: 357, 1965   DOI
23 정유선, 김종관 : 성견 3면 골내낭에서 calcium sulfate를 calcium carbonate와 혼합이식 및 차단막으로 사용할 시 치주조직의 치유효과, 연세 치대 논문집 Vol. 10, 1995
24 Cortellini, P., Pini Prato, G., Tnetti, M.S. : Periodontal regeneration of human infrabony defects, I. Clinical measure., J. Periodont., 64: 254, 1963   DOI   ScienceOn
25 Wikesjo, UME., Sigurdsson, T.J. : Guided tissue regeneration : Is it a reproducible technique. J. Periodont. Implantol. Orale., 13: 243-257, 1994
26 Yamazaki, Y., Oida, S. Akimoto, Y. : Response of mouse femoral muscle to an implant of a composite of bone morphogenetic protain and plaster of Paris, Clin. Orthop, 234 :240, 1988
27 Urist, M.R., Dowell, T.A., Hay, P.H., Strates, B.S.: Inductive substrates for bone formation, Clin. Ortho., 59: 59, 1968
28 Stahl, S.S., Froum, S.J., Kyshner, L.: Periodontal healing following open debridement flap procedures II. histologic observation, J. Periodont., 53: 15, 1982   DOI
29 Calhoun, N.R., Greene, G.W., Blackledge, G.T. : Effects of plaster of Paris implants on osteogenesis in the mandible of dogs, J. Dent. Res., 42: 1244, 1963
30 Bier, S. J. : Plaster of Paris : A periodonotal surgical dressing, N. Y. state Dent. J., 36: 347, 1970   PUBMED
31 Mellonig, J.T.: Freeze-dried bone allografts in periodonta(l reconstructive surgery, Dent. Clin. North Am., 35: 504, 1991
32 Shaffer, C.D., App, G.R. : The use of plaster of Paris in treating infrabony periodontal defects in humans, J. Periodont., 42: 685, 1971   DOI
33 Bahn, S.L. : Plaster : A bone substitute., Oral Surg., 21: 672, 1966   DOI   ScienceOn
34 Mellonig, J.T.: Decalcified freeze-dried bone allografts as an implant material in human periodontal defects, Int. J. Periodont. Res., 4(6): 41, 1984
35 Weinmann, L.P. and Sicher, H. : Bone and Bones, Ed. 2. St. Louis, C.V. Mosby Co. 38: 1955
36 Wikesjo UME., Claffey N,Egelberg : Periodontal repair in dogs; Effect of heparin treatment of the root surface, J. Clin. Periodont., 18: 60-64, 1991   DOI
37 Boyne, P.J., Cooksey, D.E., : The use of cartilage and bone implants in restoration of edentulous ridge, J. Am. Dent. Assoc., 71: 1426-1435, 1965   DOI
38 Dragoo, M.R., Sullivan, H.C.: A Clinical and histological evaluation of autogenous iliac bone grafts in humans, II. External root resorption, J. Periodont., 44: 614, 1973   DOI
39 Sottosanti, J.S. : Calcium sulfate is a safe, resorbable barrier adjunct to implant surgical procedures, Dental Implantology Update, 4: 69, 1993   PUBMED
40 Hiatt, W.H., Schallhorn, R.G., Aaronian, A.J.: The induction of new bone and cementum formation. IV. Microscopic examination of the periodontium following human bone and marrow allograft, autograft and nongraft periodontal regenerative procedures, J. Periodont., 49: 495-512, 1978   DOI
41 Nade, S., Burwell, R.G.: Decalcified bone allografts in periodontal reconstructive surgery, Dent. Clin. North Am., 35: 504, 1991
42 Ouhayoun, J.P.: Influence of biomaterials in the healing pattern of bony defects in miniature pig mandible, J. Dent. Res., 68(special issue): Abstract No. 1944, 1989
43 김종관 : 성견1면 치조골 결손부에서 특수제조된 Calcium sulfate Paste가 치주조직에 미치는 영향, 대한치조과학회지 Vol. 29, No. 1, 1999
44 Melcher, A.H. : On the repair potential periodontal tissues., J. Periodont., 47:125, 1976   DOI
45 Bell, W. H. : Resorption characteristics of bone and bone substitutes, Oral Surg., 17: 650, 1964   DOI   ScienceOn
46 Sottosanti, J.S. : Aesthetic extraction with calcium sulfate and the principle guided tissue regeneration, Pract. Periodont. & Aesthetic Dent., 5: 61, 1993
47 Sottosanti, J.S. : Calcium sulfate : A biodegradable and biocompatible barrier for guided tissue regeneration, Compend. Comt. Ed., 13(3): 226, 1992
48 Frame, J.W., Rout, P.G., Browne, R.M.: Ridge augmentation using solid and porous hydroxyapatite particles with and without autogenous bone or plaster, J Oral Maxillofac Surg., 45: 771-777, 1987   DOI   ScienceOn