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Histopathologic Study of the Effect of two Bovine Bone Powder on Healing of Extraction Socket of Dogs  

Lee, Sang-Hun (Department of Periodontology, College of Dentistry, Dan-kook University)
Lim, Sung-Bin (Department of Periodontology, College of Dentistry, Dan-kook University)
Chung, Chin-Hyung (Department of Periodontology, College of Dentistry, Dan-kook University)
Lee, Chong-Heon (Department of Oral Pathology, College of Dentistry, Dan-kook University)
Publication Information
Journal of Periodontal and Implant Science / v.32, no.2, 2002 , pp. 339-350 More about this Journal
Abstract
Recently the esthetic demands of clinicians and patients made the surgeon try to regenerate bone defects and gingival tissue after extraction. For that, many surgical methods were used and socket preservation have been evaluated simple, effective and good prognosis in the implant placement. Bone grafting was one of the methods for socket preservation. This study was to evaluate the histologic view of the effects on healing of the extraction sockets when deproteinized bovine bone mineral and tetracycline coated deproteinized bovine bone mineral was implanted 1. In control group, at 4 weeks after implantation, the extraction sockets were filled with connective tissue. And after 8 weeks, osteoblasts were observed in newly formed trabecular among the fibrous connective tissue in the extraction sockets. 2. In experimental 1 group, there was connective tissue and new bone trabecular around newly formed woven bone at 4 weeks. And many osteoblasts were observed in various direction at 8 weeks. 3. In experimental 2 group, there was a lot of new bone made around the bone powder after 4 weeks, and the thicker bone trabecular, lamellar bone and irregular osteoblasts arrangement were observed at 8 weeks. From the results of this study, tetracycline coated BBP would be better than the other groups in the lamellar bone formation and be faster in the bone formation rate.
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1 Garber DA, Rosenberg ES. The edentulous ridge in fixed prosthodontics. Compendium Contin Educ Dent 1981; 2: 212-223
2 Wetzel AC, Stich H, Caffese RG. Bone apposition onto oral implants in the sinus area filled with different grafting materials. Clin Oral Implants Res 1995; 6: 155-163   DOI   ScienceOn
3 Dies F, Etiene D, Bou Abboud N, Ouhayoun JP. Bone regeneration in extraction socket sites after immediate placement of e-PTFE membrane with or without a biomaterial. Clin Oral Implant Res 1996;7: 277-285   DOI   ScienceOn
4 Clergeau LP, Danan M, Clergeau-Guerihault S, Biro M. Healing responce to anorganic bone implantation in periodontal infrabony defect. Part I. Bone regeneration. A microradiographic study. J Periodontol 1996; 67: 140-149   DOI
5 Terranova VP, Franzetti LC, Hic S, DiFlorio RM, Lyall RM, Wikesjo UM, Baker PJ, Christersson LA, Genco RJ. A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth. J Periodont Res 1986;21:330-337   DOI   PUBMED
6 Humbert P, Renaud A, Laurent L, Agache P. Tetracyclines for epidermolysis bullosa. Lancet 1989;1:227
7 Tallgren A, Lang BR, Walker GF, Ash MM Jr. Roentgen cephalometric analysis of ridge resorption and changes in jaw and occlusal relationships in immediate complete denture wearers. J Oral Rehabil 1980; 7: 77-94   DOI   PUBMED
8 Thaller SR, Hoyt J, Borjeson K, Dart P, Tesluk H. Reconstruction of calvarial defects with anorganic barrier bone mineral in a rabbit model. J Craniofac Surg 1993; 4: 79-84   DOI   ScienceOn
9 Klinge B, Alberius P, Isaksson S, Jonsson J. Osseous response to implanted natural bone mineral and synthetic hydroxylapatite ceramics in the repair of experimental skull bone defects. J Oral Maxillofac Surg 1992; 50: 241-249   DOI   ScienceOn
10 Wetzel AC, Stich H, Caffese RG. Bone apposition onto oral implants in the sinus area filled with different grafting materials. Clin Oral Implants Res 1995; 6: 155-163.   DOI   ScienceOn
11 Masters LB, Mellonig JT, Brunsvold MA, Nummikoski PV. A clinical evaluation of demineralized freeze-dried bone allograft in combination with tetracycline in the treatment of periodontal osseous defects. J Periodontol 1996;67:770-781.   DOI   PUBMED
12 Fukuta K, Har-Shai Y, Collares MV, Lichten JB, Jackson IT. Comparison of inorganic bovine bone mineral particles with porous hydroxyapatite granules and cranial bone dust in the reconstruction of full-thickness skull defect. J Craniofac Surg 1992; 3: 25-29   DOI   ScienceOn
13 Specter M. Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration. Clin Plast Surg 1994; 3: 437-444
14 Abrams L. Augmentation of the deformed residual edentulous ridge for fixed prosthesis. Compendium Contin Educ Dent 1980; 1: 205-214
15 Ellegaard B, Karring T, Loe H. Retardation of epithelial migration in new attachment attempts in infrabony defects in monkeys. J Clin Periodontol 1976; 3: 23-37   DOI   PUBMED
16 Lane JM. Bone graft substitutes. Western J Med 1995; Dec: 565-567
17 Rummelhart JM, Mellonig JT, Gray JL, Towle HJ. A comparison of freeze-dried bone allograft and demineralized freeze-dried bone allograft in human periodontal osseous defects. J Periodontol 1989; 60: 655-663   DOI
18 Zvi Artzi, Calos EN. The application of deproteinized bovine bone mineral for ridge preservation prior to implantation: Clinical and histological observations in a case report. J Periodontol 1998; 69:1062-1067   DOI
19 Hislop WS, Finlay PM, Moos KF. A preliminary study into the uses of anorganic bovine bone in oral and maxillofacial surgery. Br J Oral Maxillofac Surg 1993; 31: 149-153   DOI   ScienceOn
20 Garraway R, Young WG, Daley T, Harbrow D, Bartold PM. An assessment of the osteoinductive potential of commercial demineralized freeze-dried bone in the murine thigh muscle implantation model. J Periodontol 1998; 69: 1325-1336   DOI
21 van Steenberghe D, Collans A, Geers L, Mys M. The use of allogenic bone particles in conjuction with immediate installation of CP titanium implants in fresh extraction wounds. J Dent Res 1997;76(Spec. Issue): 167(Abstr. 1229)
22 Allen EP, Gainza CS, Gregory GE, Newbold DA. Improved technique for localized ridge augmentation. J Periodontol 1985; 56: 195-199   DOI
23 Drury GI. Yukna RA. Histologic evaluation of combining tetracycline and allogenic freeze-dried bone on bone regeneration in experimental defects in baboons. J Periodontol 1991;62:652-658   DOI
24 Pepelassi E, Bissada NF, Greenwell H, Farah CF. Doxycycline-tricalcium phosphate graft facilitates osseous healing in advanced periodontal furcation defects. J Periodontol 1991;62:106-115   DOI
25 Langer B, Calagna L. The subepithelial connective tissue graft. J Prosthet Dent 1980; 4: 363-367
26 Cohen HV. Localized ridge augmentation with hydroxylapatite. Report of a case. J Am Dent Assoc 1984; 108: 54-56   DOI   PUBMED
27 Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR. Tetracyclines inhibit tissue collagenase activity. J Periodont Res 1984;19:651-655   DOI   PUBMED
28 Skoglund A, Hising P, Young C. A clinical and histolgic examination in humans of the osseous response to implanted natural bone mineral. Int J Oral Maxillofac Implants 1997; 12: 194-199
29 Boyne PJ. Osseous reconstruction of the maxilla and the mandible surgical techniques using titanium mesh and bone mineral: Carol Stream IL. Quintentessence Publishing 1996; 87-100
30 Hislop WS, Finlay PM, Moos KP. A preliminary study into the uses of anorganic bone in oral and maxillofacial surgery. Br J Oral Maxillofac Surg 1993; 31: 149-153   DOI   ScienceOn
31 Mabry TW, Yukna RA, Sepe WW. Freeze-dried bone allografts combined with tetracycline in the treatment of juvenile periodontitis. J Periodontol 1985;56:74-81   DOI
32 Evans GH, Yukna RA. Sepe WW, Mabry TW, Mayer ET. Effect of various graft materials with tetracycline in LJP. J Periodontol 1989;60:491-497   DOI
33 Mish CE, Dietsh F. Bone-grafting materials in implant dentistry. Implant Dent 1993; 2: 158-167   DOI   ScienceOn
34 Berglundh T, Lindhe J. Healing around implants placed in bone defects treated with Bio-Oss. Clin Oral Implants Res 1997; 8: 117-124   DOI   ScienceOn
35 Pascale D, Gordon J, Lamster I, Mann P, Seiger M, Arndt W. Concentration of doxycycline in human gingival fluid. J Clin Periodontol 1986;13:841-844   DOI   PUBMED
36 Young C, Sandstedt P, Skoglund A. A comparative study of anorganic xenogenic bone and autogenous bone implants for bone regeneration in rabbits. Int J Oral Maxillofac Implants 1999; 14: 72-76
37 Seibert JS. Reconstruction of deformed, partially edentulous ridges, using full thickness onlay grafts. Part I. Technique and wound healing. Compendium Contin Educ Dent 1983; 4: 437-453
38 Greenstein G, Jaffin RA, Hilsen KL, Berman CL. Repair of anterior gingival deformity with durapatite. A case report. J Periodontol 1985; 56: 200-203   DOI
39 Slots J, Rosling BG. Suppression of the periodontopathic microflora in LJP by systemic tetracycline. J Clin Periodontol 1983;10:465-468   DOI   PUBMED
40 Cohen RE, Mullarky RH, Noble B, Comeau RL, Neiders ME. Phenotypic characterization of mononuclear cells following anorganic bovine bone implantation in rats. J Periodontol 1994; 65: 1008-1015   DOI
41 Gordon JM, Walker CB, Murphy JC, Goodson JM, Socransky SS. Tetracycline: Levels achievable in gingival crevicular fluid and in vitroeffect on subgingival organisms.Part I. Concentrations in crevicular fluid after repeatecd doses. J Periodontol 1981;52:609-612   DOI
42 Schmitt, Buck DC, Joh SP, Lynch SE, Hollinger JO. Comparison of Porous Bone Mineral and Biologically Active Glass in Critical-Sized Defects. J Periodontol 1997; 68: 1043-1053   DOI
43 Scharf DR. Tarnow DP. Modified roll technique for localized alveolar ridge augmentation. Int J Periodontic Restorative Dent 1992; 2(5): 415-425
44 Gray JL, Quattlebaum JB. Correction of localized alveolar ridge defects utilizing hydroxyapatite and a tunneling approach. A case report. Int J Periodontics Restorative Dent 1988; 8(3): 73-78
45 Baker PJ, Evans RT, Coburn RA, Genco RJ. Tetracycline and its derivatives strongly bind to and are released from the tooth surface in an active form. J Periodontol 1983;54:580-586   DOI
46 Hurzeler MB, Kirsch A, Ackermann KL, Quinones CR. Reconstruction of the severely resorbed maxilla with dental implants in the augmented maxillary sinus: A 5-year clinical investigation. Int J Oral Maxillofac Implants 1996; 11: 466-475
47 Carlsson GE, Bergman B. Hedegard B. Changes in contour of the maxillary alveolar process under immediate denture. Acta Odontol Scand 1967; 25: 45-75   DOI   ScienceOn
48 Isaksson S. Aspects of bone healing and bone substitute incorporation. An experimental study in rabbit skull bone defects. Swed Dent J 1992; 84(Suppl.): 1-46
49 Jensen SS, Aaboe M, Pinholt EM, Hjorting-Hansen E, Melsen F, Ruyter IE. Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants 1996; 11: 55-66
50 Mecall RA, Rosenfeld AL. The influence of residual ridge resorpion patterns on implant fixture placement and tooth position: Part I. Int J Periodontics Restorative Dent 1991; 11: 9-23
51 Tallgren A. Positional changes of complete dentures: A 7-year longitudinal study. Acta Odontol Scand 1969; 27: 539-561   DOI   PUBMED   ScienceOn
52 Al-Ali W, Bissada NF, Greenwell H. The effect of local doxycycline with and without tircalcium phosphate on the regenerative healing potential of periodontal osseous defects. J Periodontol 1989;60;491-497   DOI   PUBMED