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http://dx.doi.org/10.5051/jpis.2100920046

Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study  

Blanco, Carlota (Periodontology Unit, Faculty of Odontology, University of Santiago de Compostela & Medical-Surgical Dentistry Research Group, Health Research Institute of Santiago de Compostela)
Linares, Antonio (Periodontology Unit, Faculty of Odontology, University of Santiago de Compostela & Medical-Surgical Dentistry Research Group, Health Research Institute of Santiago de Compostela)
Dopico, Jose (Periodontology Unit, Faculty of Odontology, University of Santiago de Compostela & Medical-Surgical Dentistry Research Group, Health Research Institute of Santiago de Compostela)
Pico, Alex (Periodontology Unit, Faculty of Odontology, University of Santiago de Compostela & Medical-Surgical Dentistry Research Group, Health Research Institute of Santiago de Compostela)
Sobrino, Tomas (Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela)
Leira, Yago (Periodontology Unit, Faculty of Odontology, University of Santiago de Compostela & Medical-Surgical Dentistry Research Group, Health Research Institute of Santiago de Compostela)
Blanco, Juan (Periodontology Unit, Faculty of Odontology, University of Santiago de Compostela & Medical-Surgical Dentistry Research Group, Health Research Institute of Santiago de Compostela)
Publication Information
Journal of Periodontal and Implant Science / v.51, no.5, 2021 , pp. 342-351 More about this Journal
Abstract
Purpose: The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis. Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed. Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; P<0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; P<0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8×103/µL; 95% CI, 1.6, 4.0×103/µL; P<0.001) and IL-10 (estimated adjusted mean difference, -10.4 pg/mL; 95% CI, -15.8, -5.0 pg/mL; P<0.001). The peri-implant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; P<0.001), LDL cholesterol (r=0.463; P=0.001), and WBC (r=0.519; P<0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; P<0.001). Conclusions: Otherwise healthy individuals with peri-implantitis showed increased low-grade systemic inflammation and dyslipidemia.
Keywords
Cardiovascular diseases; Dyslipidemias; Inflammation; Leukocytes; Peri-implantitis;
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1 Libby P, Bornfeldt KE, Tall AR. Atherosclerosis: successes, surprises, and future challenges. Circ Res 2016;118:531-4.   DOI
2 Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Periodontol 2018;89 Suppl 1:S267-90.   DOI
3 Derks J, Schaller D, Hakansson J, Wennstrom JL, Tomasi C, Berglundh T. Effectiveness of implant therapy analyzed in a Swedish population: prevalence of peri-implantitis. J Dent Res 2016;95:43-9.   DOI
4 Matarazzo F, Saboia-Gomes R, Alves BE, de Oliveira RP, Araujo MG. Prevalence, extent and severity of peri-implant diseases. A cross-sectional study based on a university setting in Brazil. J Periodontal Res 2018;53:910-5.   DOI
5 Rodrigo D, Sanz-Sanchez I, Figuero E, Llodra JC, Bravo M, Caffesse RG, et al. Prevalence and risk indicators of peri-implant diseases in Spain. J Clin Periodontol 2018;45:1510-20.   DOI
6 Berglundh T, Zitzmann NU, Donati M. Are peri-implantitis lesions different from periodontitis lesions? J Clin Periodontol 2011;38 Suppl 11:188-202.   DOI
7 Katz J, Flugelman MY, Goldberg A, Heft M. Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 2002;73:494-500.   DOI
8 Chaushu L, Tal H, Sculean A, Fernandez-Tome B, Chaushu G. Peri-implant disease affects systemic complete blood count values-an experimental in vivo study. Clin Oral Investig 2020;24:4531-9.   DOI
9 Memon RA, Staprans I, Noor M, Holleran WM, Uchida Y, Moser AH, et al. Infection and inflammation induce LDL oxidation in vivo. Arterioscler Thromb Vasc Biol 2000;20:1536-42.   DOI
10 Cutler CW, Shinedling EA, Nunn M, Jotwani R, Kim BO, Nares S, et al. Association between periodontitis and hyperlipidemia: cause or effect? J Periodontol 1999;70:1429-34.   DOI
11 Alvarez C, Ramos A. Lipids, lipoproteins, and apoproteins in serum during infection. Clin Chem 1986;32:142-5.   DOI
12 Gallin JI, Kaye D, O'Leary WM. Serum lipids in infection. N Engl J Med 1969;281:1081-6.   DOI
13 Chaushu L, Tal H, Sculean A, Fernandez-Tome B, Chaushu G. Effects of peri-implant infection on serum biochemical analysis. J Periodontol 2021;92:436-45.   DOI
14 Botelho J, Machado V, Hussain SB, Zehra SA, Proenca L, Orlandi M, et al. Periodontitis and circulating blood cell profiles: a systematic review and meta-analysis. Exp Hematol 2021;93:1-13.   DOI
15 von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 2008;61:344-9.   DOI
16 Raggi P, Genest J, Giles JT, Rayner KJ, Dwivedi G, Beanlands RS, et al. Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions. Atherosclerosis 2018;276:98-108.   DOI
17 Kordbacheh Changi K, Finkelstein J, Papapanou PN. Peri-implantitis prevalence, incidence rate, and risk factors: a study of electronic health records at a U.S. dental school. Clin Oral Implants Res 2019;30:306-14.   DOI
18 Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 2004;45:1169-96.   DOI
19 Shapiro MD, Fazio S. From lipids to inflammation: new approaches to reducing atherosclerotic risk. Circ Res 2016;118:732-49.   DOI
20 Vohra F, Alkhudhairy F, Al-Kheraif AA, Akram Z, Javed F. Peri-implant parameters and C-reactive protein levels among patients with different obesity levels. Clin Implant Dent Relat Res 2018;20:130-6.   DOI
21 Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015;15:30-44.   DOI
22 Nibali L, D'Aiuto F, Griffiths G, Patel K, Suvan J, Tonetti MS. Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case-control study. J Clin Periodontol 2007;34:931-7.   DOI
23 Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS One 2011;6:e20240.   DOI
24 Renvert S, Persson GR, Pirih FQ, Camargo PM. Peri-implant health, peri-implant mucositis, and periimplantitis: case definitions and diagnostic considerations. J Clin Periodontol 2018;45 Suppl 20:S278-85.   DOI
25 Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001;19:683-765.   DOI
26 Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, et al. Atherosclerosis. Nat Rev Dis Primers 2019;5:56.   DOI
27 Iacopino AM, Cutler CW. Pathophysiological relationships between periodontitis and systemic disease: recent concepts involving serum lipids. J Periodontol 2000;71:1375-84.   DOI