Browse > Article
http://dx.doi.org/10.5051/jpis.2002720136

Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy: a pilot study  

Choi, EunHa (Department of Periodontology and Research Institute of Oral Sciences, Gangneung-Wonju National University College of Dentistry)
Um, Heung-Sik (Department of Periodontology and Research Institute of Oral Sciences, Gangneung-Wonju National University College of Dentistry)
Chang, Beom-Seok (Department of Periodontology and Research Institute of Oral Sciences, Gangneung-Wonju National University College of Dentistry)
Lee, Si Young (Department of Microbiology and Immunology and Research Institute of Oral Sciences, Gangneung-Wonju National University College of Dentistry)
Lee, Jae-Kwan (Department of Periodontology and Research Institute of Oral Sciences, Gangneung-Wonju National University College of Dentistry)
Publication Information
Journal of Periodontal and Implant Science / v.51, no.1, 2021 , pp. 53-62 More about this Journal
Abstract
Purpose: This study aimed to evaluate the clinical and microbiological efficacy of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy (SPT) after initial treatment. Methods: The participants were 16 men and 8 women (age, 20-65 years) who had at least 15 natural teeth, underwent SPT for more than 1 year due to chronic periodontitis, had 4 or more periodontal pocket sites deeper than 5 mm, and showed >25% gingival bleeding on probing (BoP). They were randomly assigned to the test and control groups. In the test group, mechanical debridement and local antibiotic delivery were performed for all periodontal sulci/pockets; in the control group, mechanical debridement and saline irrigation were performed. In patients who underwent SPT for more than 1 year, clinical and microbiological examinations were performed at baseline and 1 and 3 months after SPT. The clinical examination included an assessment of the periodontal pocket depth, clinical attachment level, plaque index, and BoP. Microbial tests were performed using real-time polymerase chain reaction; the relative ratios of Porphyromonas gingivalis and Fusobacterium nucleatum were determined. Results: Both groups showed significant improvements in clinical parameters at 1 and 3 months from baseline; there were no significant changes between months 1 and 3. Intergroup differences were insignificant. The microbiological analysis revealed no significant differences in P. gingivalis and F. nucleatum ratios across time points. While intergroup differences were insignificant, there was a tendency for the P. gingivalis and F. nucleatum ratios to decrease in the test group. Conclusions: Mechanical debridement in patients receiving maintenance therapy resulted in clinically significant improvement; the effectiveness of additional local delivery of antibiotics was not significant. The ratios of P. gingivalis and F. nucleatum showed a tendency to decrease in the test group, although it was not significant.
Keywords
Chronic periodontitis; Drug delivery systems; Minocycline; Real-time polymerase chain reaction;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ciancio SG, Slots J, Reynolds HS, Zambon JJ, McKenna JD. The effect of short-term administration of minocycline HCl on gingival inflammation and subgingival microflora. J Periodontol 1982;53:557-61.   DOI
2 Bogren A, Teles RP, Torresyap G, Haffajee AD, Socransky SS, Wennstrom JL. Locally delivered doxycycline during supportive periodontal therapy: a 3-year study. J Periodontol 2008;79:827-35.   DOI
3 Murayama Y, Nomura Y, Yamaoka A, Ueda M, Hori T, Minabe M, et al. Local administration of minocycline for periodontitis. Double blind comparative study of LS-007. Nippon Shishubyo Gakkai Kaishi 1988;30:206-22.   DOI
4 van Steenberghe D, Bercy P, Kohl J, De Boever J, Adriaens P, Vanderfaeillie A, et al. Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double-blind, vehicle-controlled, multicenter study. J Periodontol 1993;64:637-44.   DOI
5 Timmerman MF, van der Weijden GA, van Steenbergen TJ, Mantel MS, de Graaff J, van der Velden U. Evaluation of the long-term efficacy and safety of locally-applied minocycline in adult periodontitis patients. J Clin Periodontol 1996;23:707-16.   DOI
6 Shiloah J, Patters MR. Repopulation of periodontal pockets by microbial pathogens in the absence of supportive therapy. J Periodontol 1996;67:130-9.   DOI
7 Albert-Kiszely A, Pjetursson BE, Salvi GE, Witt J, Hamilton A, Persson GR, et al. Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis - a six-month randomized controlled clinical trial. J Clin Periodontol 2007;34:658-67.   DOI
8 Querido SM, Cortelli SC, Araujo MW, Cortelli JR. Clinical and microbial evaluation of dental scaling associated with subgingival minocycline in chronic periodontitis subjects. Braz Oral Res 2004;18:110-5.   DOI
9 Lyons SR, Griffen AL, Leys EJ. Quantitative real-time PCR for Porphyromonas gingivalis and total bacteria. J Clin Microbiol 2000;38:2362-5.   DOI
10 Yoshida A, Suzuki N, Nakano Y, Oho T, Kawada M, Koga T. Development of a 5' fluorogenic nuclease-based real-time PCR assay for quantitative detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. J Clin Microbiol 2003;41:863-6.   DOI
11 Williams RC, Paquette DW, Offenbacher S, Adams DF, Armitage GC, Bray K, et al. Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. J Periodontol 2001;72:1535-44.   DOI
12 Jones AA, Kornman KS, Newbold DA, Manwell MA. Clinical and microbiological effects of controlled-release locally delivered minocycline in periodontitis. J Periodontol 1994;65:1058-66.   DOI
13 Matesanz-Perez P, Garcia-Gargallo M, Figuero E, Bascones-Martinez A, Sanz M, Herrera D. A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis. J Clin Periodontol 2013;40:227-41.   DOI
14 Hung HC, Douglass CW. Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss. J Clin Periodontol 2002;29:975-86.   DOI
15 Renvert S, Persson GR. Supportive periodontal therapy. Periodontol 2000 2004;36:179-95.   DOI
16 Nakagawa T, Yamada S, Oosuka Y, Saito A, Hosaka Y, Ishikawa T, et al. Clinical and microbiological study of local minocycline delivery (Periocline) following scaling and root planing in recurrent periodontal pockets. Bull Tokyo Dent Coll 1991;32:63-70.
17 Soeroso Y, Akase T, Sunarto H, Kemal Y, Salim R, Octavia M, et al. The risk reduction of recurrent periodontal pathogens of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment. Ther Clin Risk Manag 2017;13:307-14.   DOI
18 van Steenberghe D, Rosling B, Soder PO, Landry RG, van der Velden U, Timmerman MF, et al. A 15-month evaluation of the effects of repeated subgingival minocycline in chronic adult periodontitis. J Periodontol 1999;70:657-67.   DOI
19 Kato H, Yoshida A, Awano S, Ansai T, Takehara T. Quantitative detection of volatile sulfur compound-producing microorganisms in oral specimens using real-time PCR. Oral Dis 2005;11 Suppl 1:67-71.   DOI
20 Paquette D, Oringer R, Lessem J, Offenbacher S, Genco R, Persson GR, et al. Locally delivered minocycline microspheres for the treatment of periodontitis in smokers. J Clin Periodontol 2003;30:787-94.   DOI
21 Ciancio SG, Mather ML, McMullen JA. An evaluation of minocycline in patients with periodontal disease. J Periodontol 1980;51:530-4.   DOI
22 Caffesse RG, Sweeney PL, Smith BA. Scaling and root planing with and without periodontal flap surgery. J Clin Periodontol 1986;13:205-10.   DOI
23 Greenstein G, Tonetti M. The role of controlled drug delivery for periodontitis. The Research, Science and Therapy Committee of the American Academy of Periodontology. J Periodontol 2000;71:125-40.   DOI
24 Ji S, Choi YS, Choi Y. Bacterial invasion and persistence: critical events in the pathogenesis of periodontitis? J Periodontal Res 2015;50:570-85.   DOI