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http://dx.doi.org/10.5051/jpis.2018.48.4.251

Association of chairside salivary aMMP-8 findings with periodontal risk assessment parameters in patients receiving supportive periodontal therapy  

Schmalz, Gerhard (Department of Cariology, Endodontology and Periodontology, University Leipzig)
Kummer, Max Kristian (Department of Cariology, Endodontology and Periodontology, University Leipzig)
Kottmann, Tanja (Clinical Research Organization (CRO))
Rinke, Sven (Dental Practice, Hanau & Alzenau)
Haak, Rainer (Department of Cariology, Endodontology and Periodontology, University Leipzig)
Krause, Felix (Department of Cariology, Endodontology and Periodontology, University Leipzig)
Schmidt, Jana (Department of Cariology, Endodontology and Periodontology, University Leipzig)
Ziebolz, Dirk (Department of Cariology, Endodontology and Periodontology, University Leipzig)
Publication Information
Journal of Periodontal and Implant Science / v.48, no.4, 2018 , pp. 251-260 More about this Journal
Abstract
Purpose: The aim of this retrospective cross-sectional study was to evaluate whether salivary findings of active matrix-metalloproteinase 8 (aMMP-8) chairside (point of care; POC) tests were associated with periodontal risk assessment parameters in patients receiving supportive periodontal therapy (SPT). Methods: A total of 125 patients receiving regular SPT were included, and their records were examined. The following inclusion criteria were used: a diagnosis of chronic periodontitis, at least 1 non-surgical periodontal treatment (scaling and root planning) with following regular SPT (minimum once a year), at least 6 remaining teeth, and clinical and aMMP-8 findings that were obtained at the same appointment. In addition to anamnestic factors (e.g., smoking and diabetes), oral hygiene indices (modified sulcus bleeding index [mSBI] and approximal plaque index), periodontal probing depth simultaneously with bleeding on probing, and dental findings (number of decayed, missing, and filled teeth) were recorded. Salivary aMMP-8 levels were tested using a commercial POC test system (Periomarker, Hager & Werken, Duisburg, Germany). Statistical analysis was performed using the t-test, Mann-Whitney U test, Fisher's exact test, and ${\chi}^2$ test, as appropriate (P<0.05). Results: Only the mSBI was significantly associated with positive salivary aMMP-8 findings (aMMP-8 positive: $27.8%{\pm}20.9%$ vs. aMMP-8 negative: $18.0%{\pm}14.5%$; P=0.017). No significant associations were found between aMMP-8 and smoking, diabetes, periodontal parameters, or parameters related to the maintenance interval (P>0.05). Conclusions: Salivary aMMP-8 chairside findings were not associated with common parameters used for periodontal risk assessment in patients receiving SPT. The diagnostic benefit of POC salivary aMMP-8 testing in risk assessment and maintenance interval adjustment during SPT remains unclear.
Keywords
Maintenance; Metalloproteinase (aMMP-8); Periodontitis; Risk assessment; Supportive periodontal therapy;
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