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http://dx.doi.org/10.5051/jpis.2017.47.4.194

Alveolar socket preservation with demineralised bovine bone mineral and a collagen matrix  

Maiorana, Carlo (Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico Foundation, University of Milan)
Poli, Pier Paolo (Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico Foundation, University of Milan)
Deflorian, Matteo (Section of Implant Dentistry and Oral Rehabilitation, Department of Biomedical, Surgical and Dental Sciences, Dental Clinic, IRCCS Galeazzi Orthopedic Institute, University of Milan)
Testori, Tiziano (Section of Implant Dentistry and Oral Rehabilitation, Department of Biomedical, Surgical and Dental Sciences, Dental Clinic, IRCCS Galeazzi Orthopedic Institute, University of Milan)
Mandelli, Federico (Dental School, Vita-Salute University and Department of Dentistry, IRCCS San Raffaele Hospital)
Nagursky, Heiner (Medical Center, University of Freiburg Institute for Clinical Chemistry and Laboratory Medicine)
Vinci, Raffaele (Dental School, Vita-Salute University and Department of Dentistry, IRCCS San Raffaele Hospital)
Publication Information
Journal of Periodontal and Implant Science / v.47, no.4, 2017 , pp. 194-210 More about this Journal
Abstract
Purpose: The aim of the present study was to evaluate the healing of post-extraction sockets following alveolar ridge preservation clinically, radiologically, and histologically. Methods: Overall, 7 extraction sockets in 7 patients were grafted with demineralised bovine bone mineral and covered with a porcine-derived non-crosslinked collagen matrix (CM). Soft tissue healing was clinically evaluated on the basis of a specific healing index. Horizontal and vertical ridge dimensional changes were assessed clinically and radiographically at baseline and 6 months after implant placement. For histological and histomorphometric analysis, bone biopsies were harvested from the augmented sites during implant surgery 6 months after the socket preservation procedure. Results: Clinically, healing proceeded uneventfully in all the sockets. A trend towards reduced horizontal and vertical socket dimensions was observed from baseline to the final examination. The mean width and height of resorption were 1.21 mm (P=0.005) and 0.46 mm (P=0.004), respectively. Histologically, residual xenograft particles ($31.97%{\pm}3.52%$) were surrounded by either newly formed bone ($16.02%{\pm}7.06%$) or connective tissue ($50.67%{\pm}8.42%$) without fibrous encapsulation. The CM underwent a physiological substitution process in favour of well-vascularised collagen-rich connective tissue. Conclusions: Socket preservation using demineralised bovine bone mineral in combination with CM provided stable dimensional changes of the alveolar ridge associated with good reepithelialisation of the soft tissues during a 6-month healing period.
Keywords
Bone regeneration; Bone substitutes; Histology; Tooth loss;
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