Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled, clinical trial |
Deore, Girish D.
(Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre)
Gurav, Abhijit N. (Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre) Patil, Rahul (Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre) Shete, Abhijeet R. (Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre) Naiktari, Ritam S. (Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre) Inamdar, Saurabh P. (Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre) |
1 | Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. Int J Surg 2012;10:28-55. DOI ScienceOn |
2 | Moore CP. Immunomodulating agents. Vet Clin North Am Small Anim Pract 2004;34:725-37. DOI ScienceOn |
3 | Paquette DW, Williams RC. Modulation of host inflammatory mediators as a treatment strategy for periodontal diseases. Periodontol 2000 2000;24:239-52. DOI ScienceOn |
4 | Salvi GE, Lang NP. Host response modulation in the management of periodontal diseases. J Clin Periodontol 2005;32 Suppl 6:108-29. DOI ScienceOn |
5 | Ernst E. Prevalence of use of complementary/alternative medicine: a systematic review. Bull World Health Organ 2000;78:252-7. |
6 | Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 2006;11:128-50. |
7 | Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents: a systematic review. Ann Periodontol 2003;8:12-37. DOI ScienceOn |
8 | Kim MS, Yi JM, Kim SH, Hong SH, Kim HM. Madimadi, Korean folk medicine, blocks TNF-alpha, IL-1beta, and IL-8 production by activated human immune cells. Cytokine 2004;25:179-86. DOI ScienceOn |
9 | Plaeger SF. Clinical immunology and traditional herbal medicines. Clin Diagn Lab Immunol 2003;10:337-8. |
10 | Udupa AL, Rao SG, Kulkarni DR. Wound healing profile of Septilin. Indian J Physiol Pharmacol 1989;33:39-42. |
11 | Praveenkumar V, Kuttan R, Kuttan G. Immunopotentiating activity of septilin. Indian J Exp Biol 1997;35:1319-23. |
12 | Daswani BR, Yegnanarayan R. Immunomodulatory activity of septilin, a polyherbal preparation. Phytother Res 2002;16:162-5. DOI ScienceOn |
13 | Meropol SB, Chan KA, Chen Z, Finkelstein JA, Hennessy S, Lautenbach E, et al. Adverse events associated with prolonged antibiotic use. Pharmacoepidemiol Drug Saf 2008;17:523-32. DOI ScienceOn |
14 | Howell TH, Fiorellini J, Weber HP, Williams RC. Effect of the NSAID piroxicam, topically administered, on the development of gingivitis in beagle dogs. J Periodontal Res 1991;26(3 Pt 1):180-3. DOI |
15 | Shetty S, Bose A, Sridharan S, Satyanarayana A, Rahul A. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study. Oral Health Dent Manag 2013;12:95-104. |
16 | Ju HK, Baek SH, An RB, Bae K, Son KH, Kim HP, et al. Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages. Biol Pharm Bull 2003;26:1375-8. DOI ScienceOn |
17 | Van Dyke TE, Lester MA, Shapira L. The role of the host response in periodontal disease progression: implications for future treatment strategies. J Periodontol 1993;64(8 Suppl):792-806. DOI ScienceOn |
18 | Abernethy TJ, Avery OT. The occurrence during acute infections of a protein not normally present in the blood: I. Distribution of the reactive protein in patients' sera and the effect of calcium on the flocculation reaction with c polysaccharide of pneumococcus. J Exp Med 1941;73:173-82. DOI |
19 | Hedlund P. Clinical and experimental studies on C-reactive protein (acute phase protein). Acta Med Scand Suppl 1961;361:1-71. |
20 | Tillett WS, Francis T. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 1930;52:561-71. DOI |
21 | Perlman E, Bullowa JG, Goodkind R. An immunological and electrophoretic comparison of the antibody to c polysaccharide and the C-reactive protein of acute phase serum. J Exp Med 1943;77:97-110. DOI |
22 | Bhatavadekar NB, Williams RC. New directions in host modulation for the management of periodontal disease. J Clin Periodontol 2009;36:124-6. DOI ScienceOn |
23 | Ide M, McPartlin D, Coward PY, Crook M, Lumb P, Wilson RF. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clin Periodontol 2003;30:334-40. DOI ScienceOn |
24 | Slade GD, Offenbacher S, Beck JD, Heiss G, Pankow JS. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res 2000;79:49-57. DOI ScienceOn |
25 | Montebugnoli L, Servidio D, Miaton RA, Prati C, Tricoci P, Melloni C, et al. Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease. J Clin Periodontol 2005;32:188-92. DOI ScienceOn |
26 | Gani DK, Lakshmi D, Krishnan R, Emmadi P. Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis. J Indian Soc Periodontol 2009;13:69-74. DOI ScienceOn |
27 | Rattazzi M, Puato M, Faggin E, Bertipaglia B, Zambon A, Pauletto P. C-reactive protein and interleukin-6 in vascular disease: culprits or passive bystanders? J Hypertens 2003;21:1787-803. DOI ScienceOn |
28 | Soeken KL, Miller SA, Ernst E. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. Rheumatology (Oxford) 2003;42:652-9. DOI ScienceOn |
29 | Sharma SB, Ray S. Effect of herbal preparation on immune response of immunosuppressed mice. Indian J Physiol Pharmacol 1997;41:293-6. |
30 | Grewal DS, Sharma BK, Shah DD, Sheode JH. Septilin and geriforte in allergic and vasomotor rhinitis. Auris Nasus Larynx 1985;12:95-101. DOI ScienceOn |
31 | Khanna N, Sharma SB. Anti-inflammatory and analgesic effect of herbal preparation: septilin. Indian J Med Sci 2001;55:195-202. |
32 | Mattila K, Vesanen M, Valtonen V, Nieminen M, Palosuo T, Rasi V, et al. Effect of treating periodontitis on C-reactive protein levels: a pilot study. BMC Infect Dis 2002;2:30. DOI ScienceOn |
33 | D'Aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS. Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res 2005;84:269-73. DOI ScienceOn |
34 | Iwamoto Y, Nishimura F, Soga Y, Takeuchi K, Kurihara M, Takashiba S, et al. Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. J Periodontol 2003;74:1231-6. DOI ScienceOn |
35 | D'Aiuto F, Parkar M, Andreou G, Brett PM, Ready D, Tonetti MS. Periodontitis and atherogenesis: causal association or simple coincidence? J Clin Periodontol 2004;31:402-11. DOI ScienceOn |
36 | D'Aiuto F, Ready D, Tonetti MS. Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodontal Res 2004;39:236-41. DOI ScienceOn |
37 | Varma RS, Ashok G, Vidyashankar S, Patki P, Nandakumar KS. Anti-inflammatory properties of Septilin in lipopolysaccharide activated monocytes and macrophage. Immunopharmacol Immunotoxicol 2011;33:55-63. DOI ScienceOn |
38 | Page RC, Eke PI. Case definitions for use in population-based surveillance of periodontitis. J Periodontol 2007;78(7 Suppl): 1387-99. DOI ScienceOn |
39 | Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 2008;35:277-90. DOI ScienceOn |
40 | Gomes-Filho IS, Freitas Coelho JM, da Cruz SS, Passos JS, Teixeira de Freitas CO, Aragao Farias NS, et al. Chronic periodontitis and C-reactive protein levels. J Periodontol 2011;82:969-78. DOI ScienceOn |