Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease |
Chandra, Rampalli Viswa
(Department of Periodontics, SVS Institute of Dental Sciences)
Srinivas, Gorremuchu (Department of Periodontics, SVS Institute of Dental Sciences) Reddy, Aileni Amarender (Department of Periodontics, SVS Institute of Dental Sciences) Reddy, Bavigadda Harish (Department of Periodontics, SVS Institute of Dental Sciences) Reddy, Chakravarthy (Department of Periodontics, SVS Institute of Dental Sciences) Nagarajan, Sripriya (Department of Preventive and Community Dentistry, SVS Institute of Dental Sciences) Naveen, Anumala (Department of Periodontics, SVS Institute of Dental Sciences) |
1 | Kiyoshima T, Enoki N, Kobayashi I, Sakai T, Nagata K, Wada H, et al. Oxidative stress caused by a low concentration of hydrogen peroxide induces senescence-like changes in mouse gingival fibroblasts. Int J Mol Med 2012;30:1007-12. DOI |
2 | Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999;10:458-76. DOI |
3 | Borges I Jr, Moreira EA, Filho DW, de Oliveira TB, da Silva MB, Frode TS. Proinflammatory and oxidative stress markers in patients with periodontal disease. Mediators Inflamm 2007;2007:45794. |
4 | Masi S, Salpea KD, Li K, Parkar M, Nibali L, Donos N, et al. Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis. Free Radic Biol Med 2011;50:730-5. DOI |
5 | Marchetti E, Monaco A, Procaccini L, Mummolo S, Gatto R, Tete S, et al. Periodontal disease: the influence of metabolic syndrome. Nutr Metab (Lond) 2012;9:88. DOI |
6 | Govindaraj P, Khan NA, Gopalakrishna P, Chandra RV, Vanniarajan A, Reddy AA, et al. Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis. Mitochondrion 2011;11:504-12. DOI |
7 | Sugiyama S, Takahashi SS, Tokutomi FA, Yoshida A, Kobayashi K, Yoshino F, et al. Gingival vascular functions are altered in type 2 diabetes mellitus model and/or periodontitis model. J Clin Biochem Nutr 2012;51:108-13. DOI |
8 | Esen C, Alkan BA, Kirnap M, Akgul O, Isikoglu S, Erel O. The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index. J Periodontol 2012;83:773-9. DOI |
9 | Kawaguchi K, Matsumoto T, Kumazawa Y. Effects of antioxidant polyphenols on TNF-alpha-related diseases. Curr Top Med Chem 2011;11:1767-79. DOI |
10 | Soory M. Relevance of nutritional antioxidants in metabolic syndrome, ageing and cancer: potential for therapeutic targeting. Infect Disord Drug Targets 2009;9:400-14. DOI |
11 | Bagaitkar J, Williams LR, Renaud DE, Bemakanakere MR, Martin M, Scott DA, et al. Tobacco-induced alterations to Porphyromonas gingivalis-host interactions. Environ Microbiol 2009;11:1242-53. DOI |
12 | Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000 1997;14:33-53. DOI |
13 | Wood N, Johnson RB. The relationship between tomato intake and congestive heart failure risk in periodontitis subjects. J Clin Periodontol 2004;31:574-80. DOI |
14 | Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000 1997;14:12-32. DOI |
15 | Giannelli M, Chellini F, Margheri M, Tonelli P, Tani A. Effect of chlorhexidine digluconate on different cell types: a molecular and ultrastructural investigation. Toxicol In Vitro 2008;22:308-17. DOI |
16 | D'Aiuto F, Nibali L, Parkar M, Patel K, Suvan J, Donos N. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res 2010;89:1241-6. DOI |
17 | Chandra RV, Prabhuji ML, Roopa DA, Ravirajan S, Kishore HC. Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial. Oral Health Prev Dent 2007;5:327-36. |
18 | Chandra RV, Sandhya YP, Nagarajan S, Reddy BH, Naveen A, Murthy KR. Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis: smokers vs nonsmokers. Quintessence Int 2012;43:401-11. |
19 | Maruyama T, Tomofuji T, Endo Y, Irie K, Azuma T, Ekuni D, et al. Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Arch Oral Biol 2011;56:48-53. DOI |
20 | Fuhrman B, Elis A, Aviram M. Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. Biochem Biophys Res Commun 1997;233:658-62. DOI |
21 | Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274:532-8. DOI |
22 | Dalcico R, de Menezes AM, Deocleciano OB, Oria RB, Vale ML, Ribeiro RA, et al. Protective Mechanisms of Simvastatin in Experimental Periodontal Disease. J Periodontol. 2012 Nov 26 [Epub]. http://dx.doi.org/10.1902/jop.2012.120114. |
23 | Kara A, Akman S, Ozkanlar S, Tozoglu U, Kalkan Y, Canakci CF, et al. Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats. Free Radic Biol Med 2013;55:21-6. DOI |
24 | Ku SK, Cho HR, Sung YS, Kang SJ, Lee YJ. Effects of calcium gluconate on experimental periodontitis and alveolar bone loss in rats. Basic Clin Pharmacol Toxicol 2011;108:241-50. DOI |
25 | Canakci CF, Cicek Y, Yildirim A, Sezer U, Canakci V. Increased levels of 8-hydroxydeoxyguanosine and malondialdehyde and its relationship with antioxidant enzymes in saliva of periodontitis patients. Eur J Dent 2009;3:100-6. |
26 | Konopka T, Krol K, Kopec W, Gerber H. Total antioxidant status and 8-hydroxy-2's-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients. Arch Immunol Ther Exp (Warsz) 2007;55:417-22. DOI |
27 | Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of victamine C. J Periodontol 1970;41:41-3. DOI |
28 | Lobene RR, Weatherford T, Ross NM, Lamm RA, Menaker L. A modified gingival index for use in clinical trials. Clin Prev Dent 1986;8:3-6. |
29 | Patel SA, Patel NM, Patel MM. Spectrophotometric methods for the estimation of cephalexin in tablet dosage forms. Indian J Pharma Sci 2006;68:278-80. DOI |
30 | Tuter G, Kurtis B, Serdar M. Interleukin-1beta and thiobarbituric acid reactive substance (TBARS) levels after phase I periodontal therapy in patients with chronic periodontitis. J Periodontol 2001;72:883-8. DOI |
31 | Battino M, Ferreiro MS, Fattorini D, Bullon P. In vitro antioxidant activities of mouthrinses and their components. J Clin Periodontol 2002;29:462-7. DOI |
32 | Neiva RF, Steigenga J, Al-Shammari KF, Wang HL. Effects of specific nutrients on periodontal disease onset, progression and treatment. J Clin Periodontol 2003;30:579-89. DOI |
33 | Watts T. Periodontal treatment and glycemic control in diabetic patients: the problem of a possible Hawthorne effect. J Dent Res 2006;85:294. DOI |
34 | Bansal K, Rawat MK, Jain A, Rajput A, Chaturvedi TP, Singh S. Development of satranidazole mucoadhesive gel for the treatment of periodontitis. AAPS PharmSciTech 2009;10:716-23. DOI |
35 | Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 2004;142:231-55. DOI |
36 | Palozza P, Parrone N, Simone R, Catalano A. Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention. Curr Med Chem 2011;18:1846-60. DOI |
37 | Dede FO, Ozden FO, Avci B. 8-hydroxy-deoxyguanosine levels in gingival crevicular fluid and saliva in patients with chronic periodontitis after initial periodontal treatment. J Periodontol 2013;84:821-8. DOI |
38 | Jakubowski W, Bartosz G. 2,7-dichlorofluorescin oxidation and reactive oxygen species: what does it measure? Cell Biol Int 2000;24:757-60. DOI |
39 |
Myhre O, Andersen JM, Aarnes H, Fonnum F. Evaluation of the probes |
40 | Wolfe KL, Liu RH. Structure-activity relationships of flavonoids in the cellular antioxidant activity assay. J Agric Food Chem 2008;56:8404-11. DOI |
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